Search Results - "Lu, Yongke"

Role of oxidative stress in alcohol-induced liver injury by Cederbaum, Arthur I, Lu, Yongke, Wu, Defeng

“…Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated in small amounts during the body's metabolic reactions and can react…”
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Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches by George, Joseph, Lu, Yongke, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro

“…Ischemia-reperfusion (IR) or reoxygenation injury is the paradoxical exacerbation of cellular impairment following restoration of blood flow after a period of…”
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Associations of ARHGAP26 Polymorphisms with Alzheimer’s Disease and Cardiovascular Disease by Wang, Kesheng, Lu, Yongke, Morrow, Deana F., Xiao, Danqing, Xu, Chun

“…The Rho GTPase activating protein 26 ( ARHGAP26 ) gene has been reported to be associated with neuropsychiatric diseases and neurodegenerative diseases…”
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Cytochrome P450 2E1 contributes to ethanol‐induced fatty liver in mice by Lu, Yongke, Zhuge, Jian, Wang, Xiaodong, Bai, Jingxiang, Cederbaum, Arthur I.

“…Cytochrome P450 2E1 (CYP2E1) is suggested to play a role in alcoholic liver disease, which includes alcoholic fatty liver, alcoholic hepatitis, and alcoholic…”
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Alcoholic Liver Disease: from CYP2E1 to CYP2A5 by Leung, Tung Ming, Lu, Yongke

“…This article reviews recent studies on CYP2E1-mediated alcoholic liver injury, the induction of CYP2A5 by alcohol and the mechanism for this upregulation,…”
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High Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD) by Ge, Xiaodong, Antoine, Daniel J., Lu, Yongke, Arriazu, Elena, Leung, Tung-Ming, Klepper, Arielle L., Branch, Andrea D., Fiel, Maria Isabel, Nieto, Natalia

“…Growing clinical and experimental evidence suggests that sterile inflammation contributes to alcoholic liver disease (ALD). High mobility group box-1 (HMGB1)…”
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Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice by Lu, Yongke, Wu, Defeng, Wang, Xiaodong, Ward, Stephen C., Cederbaum, Arthur I.

“…A major pathway for chronic ethanol-induced liver injury is ethanol-induced oxidant stress. Several pathways contribute to mechanisms by which ethanol induces…”
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Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway by Lu, Yongke, Zhang, Xu Hannah, Cederbaum, Arthur I

“…Chronic ethanol consumption was previously shown to induce CYP2A5 in mice, and this induction of CYP2A5 by ethanol was CYP2E1 dependent. In this study, the…”
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Longitudinal analysis of APOE-ε4 genotype with the logical memory delayed recall score in Alzheimer’s disease by Fokuoh, Evelyn, Xiao, Danqing, Fang, Wei, Liu, Ying, Lu, Yongke, Wang, Kesheng

“…No study has focussed on the longitudinal effect of APOE-ε4 genotype on the logical memory delayed recall total (LDELTOTAL) score in late-onset Alzheimer’s…”
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Midbrain circuit regulation of individual alcohol drinking behaviors in mice by Juarez, Barbara, Morel, Carole, Ku, Stacy M., Liu, Yutong, Zhang, Hongxing, Montgomery, Sarah, Gregoire, Hilledna, Ribeiro, Efrain, Crumiller, Marshall, Roman-Ortiz, Ciorana, Walsh, Jessica J., Jackson, Kelcy, Croote, Denise E., Zhu, Yingbo, Zhang, Song, Vendruscolo, Leandro F., Edwards, Scott, Roberts, Amanda, Hodes, Georgia E., Lu, Yongke, Calipari, Erin S., Chaudhury, Dipesh, Friedman, Allyson K., Han, Ming-Hu

“…Alcohol-use disorder (AUD) is the most prevalent substance-use disorder worldwide. There is substantial individual variability in alcohol drinking behaviors in…”
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Genome-wide DNA methylation analysis in schizophrenia with tardive dyskinesia: a preliminary study by Zhang, Ping, Lu, Yongke, Li, Yanli, Wang, Kesheng, An, Huimei, Tan, Yunlong

“…Background Tardive dyskinesia (TD) develops in 20–30% of schizophrenia patients and up to 50% in patients > 50 years old. DNA methylation may play an important…”
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Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity by Lu, Yongke, Cederbaum, Arthur I

“…Autophagy is an intracellular pathway by which lysosomes degrade and recycle long-lived proteins and cellular organelles. The effects of ethanol on autophagy…”
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Cisplatin-Induced Hepatotoxicity Is Enhanced by Elevated Expression of Cytochrome P450 2E1 by Lu, Yongke, Cederbaum, Arthur I.

“…In this study, the possible potentiation of cisplatin-induced hepatotoxicity by cytochrome P450 2E1 (CYP2E1) was examined both in vitro and in vivo…”
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Milk osteopontin, a nutritional approach to prevent alcohol-induced liver injury by Ge, Xiaodong, Lu, Yongke, Leung, Tung-Ming, Sørensen, Esben S, Nieto, Natalia

“…Alcohol consumption is a leading cause of liver disease worldwide; thus, there is an urgent need to develop novel therapeutic interventions. Key events for the…”
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Levels of Angiotensin-Converting Enzyme and Apolipoproteins Are Associated with Alzheimer's Disease and Cardiovascular Diseases by Xu, Chun, Garcia, Debra, Lu, Yongke, Ozuna, Kaysie, Adjeroh, Donald A, Wang, Kesheng, On Behalf Of The Alzheimer's Disease Neuroimaging Initiative

“…Angiotensin-converting enzyme-1 (ACE1) and apolipoproteins (APOs) may play important roles in the development of Alzheimer's disease (AD) and cardiovascular…”
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Ethanol Induction of CYP2A5: Permissive Role for CYP2E1 by YONGKE LU, JIAN ZHUGE, DEFENG WU, CEDERBAUM, Arthur I

“…CYP2A5 metabolizes xenobiotics and activates hepatocarcinogens, and induction occurs in response to hepatic damage and cellular stress. We evaluated whether…”
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Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity by Chen, Xue, Wang, Long, Denning, Krista L, Mazur, Anna, Xu, Yujuan, Wang, Kesheng, Lawrence, Logan M, Wang, Xiaodong, Lu, Yongke

“…Obesity results in hepatic fat accumulation, i.e., steatosis. In addition to fat overload, impaired fatty acid β-oxidation also promotes steatosis. Fatty acid…”
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Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice by Ming Leung, Tung, Lu, Yongke, Yan, Wei, Morón-Concepción, José A., Ward, Stephen C., Ge, Xiaodong, Conde de la Rosa, Laura, Nieto, Natalia

“…Argininosuccinate synthase (ASS) is the rate‐limiting enzyme in both the urea and the L‐citrulline/nitric oxide (NO·) cycles regulating protein catabolism,…”
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Enhancement by pyrazole of lipopolysaccharide‐induced liver injury in mice: Role of cytochrome P450 2E1 and 2A5 by Lu, Yongke, Cederbaum, Arthur I.

“…The mechanisms by which alcohol causes liver injury are still not certain. Either LPS or CYP2E1 are considered independent risk factors involved in alcoholic…”
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Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice by Hong, Feng, Liu, Xiyu, Ward, Stephen S, Xiong, Huabao, Cederbaum, Arthur I, Lu, Yongke

“…Abstract Background Ethanol can induce cytochrome P450 2E1, an active generator of reactive oxygen species, and this cytochrome is considered a risk factor for…”
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