Search Results - "Lu, YingJuan"

Folate-mediated delivery of macromolecular anticancer therapeutic agents by Lu, Yingjuan, Low, Philip S.

“…The receptor for folic acid constitutes a useful target for tumor-specific drug delivery, primarily because: (1) it is upregulated in many human cancers,…”
Get full text

Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters by Lee, Yong Gu, Chu, Haiyan, Lu, Yingjuan, Leamon, Christopher P., Srinivasarao, Madduri, Putt, Karson S., Low, Philip S.

“…Although chimeric antigen receptor (CAR) T cell therapies have demonstrated considerable success in treating hematologic malignancies, they have simultaneously…”
Get full text

HBx/ERα complex-mediated LINC01352 downregulation promotes HBV-related hepatocellular carcinoma via the miR-135b-APC axis by Huang, Pinbo, Xu, Qiaodong, Yan, Yongcong, Lu, Yingjuan, Hu, Zhigang, Ou, Bing, Zhang, Heyun, Mao, Kai, Zhang, Jianlong, Wang, Jie, Xiao, Zhiyu

“…Hepatitis B virus (HBV) infection plays an important role in hepatocarcinogenesis, especially in hepatocellular carcinoma (HCC). Long non-coding RNAs (lncRNAs)…”
Get full text

Long Noncoding RNA MPRL Promotes Mitochondrial Fission and Cisplatin Chemosensitivity via Disruption of Pre-miRNA Processing by Tian, Tian, Lv, Xiaobin, Pan, Guokai, Lu, Yingjuan, Chen, Weixiong, He, Wang, Lei, Xinyuan, Zhang, Hanqing, Liu, Mo, Sun, Sheng, Ou, Zhanpeng, Lin, Xinyu, Cai, Lei, He, Lile, Tu, Zhiming, Wang, Xinhui, Tannous, Bakhos A, Ferrone, Soldano, Li, Jinsong, Fan, Song

“…The overall biological roles and clinical significance of most long noncoding RNAs (lncRNA) in chemosensitivity are not fully understood. We investigated the…”
Get full text

Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma by Lu, Yingjuan, Li, Yingru, Wang, Zhangsong, Xie, Shule, Wang, Qing, Lei, Xinyuan, Ruan, Yi, Li, Jinsong

“…[Display omitted] •RGMA extremely decreases in OSCC and correlates with T stages and poor prognosis.•RGMA overexpression in OSCC inhibits cell proliferation,…”
Get full text

Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies by Lu, Yingjuan J, Chu, Haiyan, Wheeler, Leroy W, Nelson, Melissa, Westrick, Elaine, Matthaei, James F, Cardle, Ian I, Johnson, Adam, Gustafson, Joshua, Parker, Nikki, Vetzel, Marilynn, Xu, Le-Cun, Wang, Emilia Z, Jensen, Michael C, Klein, Patrick J, Low, Philip S, Leamon, Christopher P

“…Chimeric antigen receptor (CAR)-T cell therapy has transformed pediatric oncology by producing high remission rates and potent effects in CD19+ B-cell…”
Get full text

Primary stability analysis of the torque-resistant orthodontic miniscrew anchorage by Ye, Yushan, Zhang, Jianna, Hao, Yunru, He, Jieying, Wang, Yamei, Lu, Yingjuan, Chang, Shaohai

“…Though miniscrews are widely used as a temporary anchorage device, research focusing on the primary stability of miniscrew loading torque force is limited…”
Get full text

A Novel Prognostic Model for Oral Squamous Cell Carcinoma: The Functions and Prognostic Values of RNA-Binding Proteins by Lu, Yingjuan, Yan, Yongcong, Li, Bowen, Liu, Mo, Liang, Yancan, Ye, Yushan, Cheng, Weiqi, Li, Jinsong, Jiao, Jiuyang, Chang, Shaohai

“…Purpose The biological roles and clinical significance of RNA-binding proteins (RBPs) in oral squamous cell carcinoma (OSCC) are not fully understood. We…”
Get full text

Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors by YINGJUAN LU, LOW, Philip S

“…A variety of human cancers overexpress a cell surface receptor with high affinity for the vitamin, folic acid ( K(d) approximately 10(-10)M). Covalent…”
Get full text

Detecting Functional and Accessible Folate Receptor Expression in Cancer and Polycystic Kidneys by Chu, Haiyan, Shillingford, Jonathan M, Reddy, Joseph A, Westrick, Elaine, Nelson, Melissa, Wang, Emilia Z, Parker, Nikki, Felten, Albert E, Vaughn, Jeremy F, Xu, Le-Cun, Lu, Yingjuan J, Vlahov, Iontcho R, Leamon, Christopher P

“…Folate-based small molecule drug conjugates (SMDCs) are currently under development and have shown promising preclinical and clinical results against various…”
Get full text

Folate-Hapten-Mediated Immunotherapy Synergizes with Vascular Endothelial Growth Factor Receptor Inhibitors in Treating Murine Models of Cancer by Bandara, N Achini, Bates, Cody D, Lu, Yingjuan, Hoylman, Emily K, Low, Philip S

“…The overexpression of folate receptors (FR) on many human cancers has led to the development of folate-linked drugs for the imaging and therapy of…”
Get full text

Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospects by Lu, Yingjuan, Low, Philip S.

“…The cell surface receptor for the vitamin folic acid (termed the folate receptor), is often elevated in cancers of the ovary, kidney, lung, mammary gland,…”
Get full text

Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes by Lu, Yingjuan J., Wheeler, Leroy W., Chu, Haiyan, Kleindl, Paul J., Pugh, Michael, You, Fei, Rao, Satish, Garcia, Gabriela, Wu, Henry Y., da Cunha, Andre P., Johnson, Richard, Westrick, Elaine, Cross, Vicky, Lloyd, Alex, Dircksen, Christina, Klein, Patrick J., Vlahov, Iontcho R., Low, Philip S., Leamon, Christopher P.

“…Provoked by sterile/nonsterile insults, prolonged monocyte mobilization and uncontrolled monocyte/macrophage activation can pose imminent or impending harm to…”
Get full text

A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats by Garcia, Gabriela E, Lu, Yingjuan J, Truong, Luan D, Roncal-Jiménez, Carlos A, Miyazaki, Makoto, Miyazaki-Anzai, Shinobu, Cara-Fuentes, Gabriel, Andres-Hernando, Ana, Lanaspa, Miguel, Johnson, Richard J, Leamon, Christopher P

“…Since activated macrophages express a functional folate receptor β (FRβ), targeting this macrophage population with folate-linked drugs could increase…”
Get full text

Finite Element Analysis of Orthodontic Relapse in Different Maxillary Arch Form by Li, Yuanyuan, Shao, Yiting, Yu, Yansong, Ye, Yushan, Lu, Yingjuan, Chang, Shaohai

“…Abstract Background: Orthodontic relapse is fairly common; however, the mechanisms between relapse and the dental arch form remain unclear. The purpose of our…”
Get full text

Folate receptor‐targeted immunotherapy: Induction of humoral and cellular immunity against hapten‐decorated cancer cells by Lu, Yingjuan, Sega, Emanuela, Low, Philip S.

“…We previously exploited the frequent overexpression of folate receptors on cancer cells to decorate malignant cell surfaces selectively with folate‐hapten…”
Get full text

Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis by Elo, Petri, Li, Xiang-Guo, Liljenbäck, Heidi, Gardberg, Maria, Moisio, Olli, Miner, Maxwell, Virta, Jenni, Saraste, Antti, Srinivasarao, Madduri, Pugh, Michael, Low, Philip S, Knuuti, Juhani, Jalkanen, Sirpa, Airas, Laura, Lu, Yingjuan June, Roivainen, Anne

“…Activated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor-β (FR-β), representing a promising target for the treatment…”
Get full text

Synthesis and activity of folate conjugated didemnin B for potential treatment of inflammatory diseases by Henne, Walter A., Kularatne, Sumith A., Ayala-López, Wilfredo, Doorneweerd, Derek D., Stinnette, Torian W., Lu, Yingjuan, Low, Philip S.

“…A folate receptor targeted didemnin B conjugate was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate…”
Get full text

Low-Dose Radiation Potentiates the Therapeutic Efficacy of Folate Receptor–Targeted Hapten Therapy by Sega, Emanuela I., Ph.D, Lu, Yingjuan, Ph.D, Ringor, Michael, Ph.D, Leamon, Christopher P., Ph.D, Low, Philip S., Ph.D

“…Purpose Human cancers frequently overexpress a high-affinity cell-surface receptor for the vitamin folic acid. Highly immunogenic haptens can be targeted to…”
Get full text

Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate–targeted immunotherapy in hapten-immunized mice by Lu, Yingjuan, Xu, Le-Cun, Parker, Nikki, Westrick, Elaine, Reddy, Joseph A, Vetzel, Marilynn, Low, Philip S, Leamon, Christopher P

“…Folic acid (pteroylglutamic acid) represents a useful ligand for targeted cancer therapies because it binds to a common epithelial tumor antigen known as the…”
Get full text