Search Results - "Lu, W. William"

Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics by Lin, Kaili, Xia, Lunguo, Li, Haiyan, Jiang, Xinquan, Pan, Haobo, Xu, Yuanjin, Lu, William W, Zhang, Zhiyuan, Chang, Jiang

“…Abstract The regeneration capacity of the osteoporotic bones is generally lower than that of the normal bones. Current methods of bone defect treatment for…”
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A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress-induced bone loss by Yang, Fan, Liu, Yunhui, Chen, Shanping, Dai, Zhongquan, Yang, Dazhi, Gao, Dashuang, Shao, Jie, Wang, Yuyao, Wang, Ting, Zhang, Zhijian, Zhang, Lu, Lu, William W, Li, Yinghui, Wang, Liping

“…Homeostasis of bone metabolism is regulated by the central nervous system, and mood disorders such as anxiety are associated with bone metabolism…”
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Apatite-formation ability – Predictor of “bioactivity”? by Pan, Haobo, Zhao, Xiaoli, Darvell, Brian W., Lu, William W.

“…The ability to trigger the formation of apatite from a supersaturated solution has been widely used to imply the bioactivity of an implant in vivo. However,…”
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Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis by Chen, Yan, Hu, Yizhong, Yu, Y Eric, Zhang, Xingjian, Watts, Tezita, Zhou, Bin, Wang, Ji, Wang, Ting, Zhao, Weiwei, Chiu, Kwong Yuen, Leung, Frankie KL, Cao, Xu, Macaulay, William, Nishiyama, Kyle K, Shane, Elizabeth, Lu, William W, Guo, X Edward

“…ABSTRACT Developing effective treatment for osteoarthritis (OA), a prevalent and disabling disease, has remained a challenge, primarily because of limited…”
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Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration by Liu, Wenlong, Dan, Xiuli, Lu, William W, Zhao, Xiaoli, Ruan, Changshun, Wang, Ting, Cui, Xu, Zhai, Xinyun, Ma, Yufei, Wang, Deping, Huang, Wenhai, Pan, Haobo

“…It is generally accepted that biodegradable materials greatly influence the nearby microenvironment where cells reside; however, the range of interfacial…”
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Effects of strontium in modified biomaterials by Zhang, Weibin, Shen, Yuhui, Pan, Haobo, Lin, Kaili, Liu, Xiaoguo, Darvell, Brian W., Lu, William W., Chang, Jiang, Deng, Lianfu, Wang, Deping, Huang, Wenhai

“…Strontium (Sr) plays a special role in bone remodelling, being associated with both the stimulation of bone formation and a reduction in bone resorption. Thus,…”
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Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy by Li, Feiyang, Wu, Jun, Li, Daiye, Hao, Liuzhi, Li, Yanqun, Yi, Dan, Yeung, Kelvin W K, Chen, Di, Lu, William W, Pan, Haobo, Wong, Tak Man, Zhao, Xiaoli

“…Exosomes derived from stem cells have been widely studied for promoting regeneration and reconstruction of multiple tissues as "cell-free" therapies. However,…”
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An optogenetic approach for regulating human parathyroid hormone secretion by Liu, Yunhui, Zhang, Lu, Hu, Nan, Shao, Jie, Yang, Dazhi, Ruan, Changshun, Huang, Shishu, Wang, Liping, Lu, William W., Zhang, Xinzhou, Yang, Fan

“…Parathyroid hormone (PTH) plays crucial role in maintaining calcium and phosphorus homeostasis. In the progression of secondary hyperparathyroidism (SHPT),…”
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The effects of microenvironment in mesenchymal stem cell–based regeneration of intervertebral disc by Huang, Yong-Can, MPhil, Leung, Victor Y.L., PhD, Lu, William W., PhD, Luk, Keith D.K., MCh Orth

“…Abstract Background context Recent studies have demonstrated new therapeutic strategy using transplantation of mesenchymal stem cells (MSCs), especially bone…”
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Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression by Cui, Xu, Huang, Chengcheng, Chen, Zhizhen, Zhang, Meng, Liu, Chunyu, Su, Kun, Wang, Jianyun, Li, Li, Wang, Renxian, Li, Bing, Chen, Dafu, Ruan, Changshun, Wang, Deping, Lu, William W., Pan, Haobo

“…Calcium phosphate cements (CPC) are widely anticipated to be an optimum bone repair substitute due to its satisfied biocompatibility and degradability,…”
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miR-375-3p negatively regulates osteogenesis by targeting and decreasing the expression levels of LRP5 and β-catenin by Sun, Tianhao, Li, Chen-Tian, Xiong, Lifeng, Ning, Ziyu, Leung, Frankie, Peng, Songlin, Lu, William W

“…Wnt signaling pathways are essential for bone formation. Previous studies showed that Wnt signaling pathways were regulated by miR-375. Thus, we aim to explore…”
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The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: Involvement of osteoprotegerin by Peng, Songlin, Liu, X. Sherry, Huang, Shishu, Li, Zhaoyang, Pan, Haobo, Zhen, Wanxin, Luk, K.D.K, Guo, X. Edward, Lu, W. William

“…Abstract Background The mechanism for the uncoupling effects of Sr on bone remains to be evaluated. Osteoblasts play important roles in osteoclastogenesis…”
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Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview by Zhang, Meng, Matinlinna, Jukka P., Tsoi, James K.H., Liu, Wenlong, Cui, Xu, Lu, William W., Pan, Haobo

“…Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required…”
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MiR-9-5p, miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation, Differentiation, and Adhesion by Sun, Tianhao, Leung, Frankie, Lu, William W

“…This study was designed to evaluate the effects of strontium on the expression levels of microRNAs (miRNAs) and to explore their effects on skeletal cell…”
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Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass by Cui, Xu, Huang, Chengcheng, Zhang, Meng, Ruan, Changshun, Peng, Songlin, Li, Li, Liu, Wenlong, Wang, Ting, Li, Bing, Huang, Wenhai, Rahaman, Mohamed N., Lu, William W., Pan, Haobo

“…Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity…”
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Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms by Wei, Guizheng, Lu, Ke, Umar, Muhammad, Zhu, Zhenglin, Lu, William W, Speakman, John R, Chen, Yan, Tong, Liping, Chen, Di

“…Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has…”
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Strontium Promotes Osteogenic Differentiation of Mesenchymal Stem Cells Through the Ras/MAPK Signaling Pathway by Peng, Songlin, Zhou, Guangqian, Luk, Keith D.K., Cheung, Kenneth M.C., Li, Zhaoyang, Lam, Wing Moon, Zhou, Zhongjun, Lu, William W.

“…Strontium ralenate is a new anti-osteoporosis agent. The cellular and molecular mechanism underlying the anabolic effect of strontium on bone remains to be…”
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Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling by Zeng, Daofu, Umar, Muhammad, Zhu, Zhenglin, Pan, Haobo, Lu, William W., Xiao, Guozhi, Chen, Yan, Tong, Liping, Chen, Di

“…Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA…”
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Interfacial pH: A Critical Factor for Osteoporotic Bone Regeneration by Shen, Yuhui, Liu, Waiching, Lin, Kaili, Pan, Haobo, Darvell, Brian W, Peng, Songlin, Wen, Chunyi, Deng, Lianfu, Lu, William W, Chang, Jiang

“…Osteoporosis is a disease attributed to an imbalance in communication between osteoblasts and osteoclasts, possibly arising from a locally acidic…”
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Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway by Cui, Xu, Zhang, Yadong, Wang, Jianyun, Huang, Chengcheng, Wang, Yudong, Yang, Hongsheng, Liu, Wenlong, Wang, Ting, Wang, Deping, Wang, Guocheng, Ruan, Changshun, Chen, Dafu, Lu, William W., Huang, Wenhai, Rahaman, Mohamed N., Pan, Haobo

“…There is a need for synthetic grafts to reconstruct large bone defects using minimal invasive surgery. Our previous study showed that incorporation of Sr into…”
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