Search Results - "Lu, Steve"

The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors by Rousseau, Benoit, Foote, Michael B, Maron, Steven B, Diplas, Bill H, Lu, Steve, Argilés, Guillem, Cercek, Andrea, Diaz, Luis A

“…The FDA has approved immune checkpoint inhibitors for solid tumors of any histologic origin with more than 10 mutations per megabase of DNA. This study showed…”
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Effectiveness of instrument-assisted soft tissue mobilization for the management of upper body, lower body, and spinal conditions. An updated systematic review with meta-analyses by Nazari, Goris, Bobos, Pavlos, Lu, Steve (Ze), Reischl, Stephanie, Sharma, Saurab, Le, Christina Y., Vader, Kyle, Held, Nicholas, MacDermid, Joy C.

“…To critically appraise randomized controlled trials (RCTs) on Instrument-Assisted Soft Tissue Mobilisation (IASTM) and quantify the effects of IASTM compared…”
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity by Lu, Changzheng, Guan, Junhong, Lu, Steve, Jin, Qihuang, Rousseau, Benoit, Lu, Tianshi, Stephens, Dennis, Zhang, Hongyi, Zhu, Jiankun, Yang, Mingming, Ren, Zhenhua, Liang, Yong, Liu, Zhida, Han, Chuanhui, Liu, Longchao, Cao, Xuezhi, Zhang, Anli, Qiao, Jian, Batten, Kimberly, Chen, Mingyi, Castrillon, Diego H., Wang, Tao, Li, Bo, Diaz, Luis A., Li, Guo-Min, Fu, Yang-Xin

“…Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency (dMMR) are proposed as the major contributor to the high objective response…”
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Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes by Lu, Steve, Wang, Guliang, Bacolla, Albino, Zhao, Junhua, Spitser, Scott, Vasquez, Karen M.

“…Analyses of chromosomal aberrations in human genetic disorders have revealed that inverted repeat sequences (IRs) often co-localize with endogenous chromosomal…”
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The rapid and highly parallel identification of antibodies with defined biological activities by SLISY by Lu, Steve, Mattox, Austin K., Aitana Azurmendi, P., Christodoulou, Ilias, Wright, Katharine M., Popoli, Maria, Chen, Zan, Sur, Surojit, Li, Yana, Bonifant, Challice L., Bettegowda, Chetan, Papadopoulos, Nickolas, Zhou, Shibin, Gabelli, Sandra B., Vogelstein, Bert, Kinzler, Kenneth W.

“…The therapeutic applications of antibodies are manifold and the emergence of SARS-CoV-2 provides a cogent example of the value of rapidly identifying…”
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Computing Statistics from Private Data by Alter, George, Falk, Brett Hemenway, Lu, Steve, Ostrovsky, Rafail

“…In several domains, privacy presents a significant obstacle to scientific and analytic research, and limits the economic, social, health and scholastic…”
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Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates by Wang, Yu, Johnson, Douglas B, Lu, Steve, Diaz, Jr, Luis A, Xu, Yaomin, Balko, Justin M

“…The progression of cancer requires mutational adaptation to permit unrestrained proliferation. A fraction of cancer mutations are oncogenic drivers, while…”
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CCR exchange: building a patient-driven web-based healthcare community around an emerging personal health record standard by Lu, Steve Chi-Hung

“…This document demonstrates how we use open source software in building an Internet healthcare community around an emerging Personal Health Record standard…”
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VerteFormer: A single-staged Transformer network for vertebrae segmentation from CT images with arbitrary field of views by You, Xin, Gu, Yun, Liu, Yingying, Lu, Steve, Tang, Xin, Yang, Jie

“…Spinal diseases are burdening an increasing number of patients. And fully automatic vertebrae segmentation for CT images with arbitrary field of views (FOVs),…”
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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade by Le, Dung T., Durham, Jennifer N., Smith, Kellie N., Wang, Hao, Bartlett, Bjarne R., Aulakh, Laveet K., Lu, Steve, Kemberling, Holly, Wilt, Cara, Luber, Brandon S., Wong, Fay, Azad, Nilofer S., Rucki, Agnieszka A., Laheru, Dan, Donehower, Ross, Zaheer, Atif, Fisher, George A., Crocenzi, Todd S., Lee, James J., Greten, Tim F., Duffy, Austin G., Ciombor, Kristen K., Eyring, Aleksandra D., Lam, Bao H., Joe, Andrew, Kang, S. Peter, Holdhoff, Matthias, Danilova, Ludmila, Cope, Leslie, Meyer, Christian, Zhou, Shibin, Goldberg, Richard M., Armstrong, Deborah K., Bever, Katherine M., Fader, Amanda N., Taube, Janis, Housseau, Franck, Spetzler, David, Xiao, Nianqing, Pardoll, Drew M., Papadopoulos, Nickolas, Kinzler, Kenneth W., Eshleman, James R., Vogelstein, Bert, Anders, Robert A., Diaz, Luis A.

“…The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed…”
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Rasch Analysis of Joint Replacement Version for Hip Disability and Osteoarthritis Outcome in Individuals With Advanced Osteoarthritis of Hip Awaiting Total Hip Arthroplasty Surgery by Mehta, Saurabh P, Ellis, Ashley Paige, Meadows, Samantha, Lu, Steve, Bullock, Matthew, Oliashirazi, Ali

“…The objective of this study was to examine measurement properties of the Joint replacement version for Hip Disability and Osteoarthritis Outcome Score…”
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Psychometric properties of the single assessment numeric evaluation in patients with lower extremity pathologies. A systematic review by Nazari, Goris, Bobos, Pavlos, Lu, Steve, MacDermid, Joy C.

“…To identify, critically appraise and synthesize the reported psychometric properties of the Single Assessment Numeric Evaluation in patients with lower…”
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Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade by Georgiadis, Andrew, Durham, Jennifer N, Keefer, Laurel A, Bartlett, Bjarne R, Zielonka, Magdalena, Murphy, Derek, White, James R, Lu, Steve, Verner, Ellen L, Ruan, Finey, Riley, David, Anders, Robert A, Gedvilaite, Erika, Angiuoli, Sam, Jones, Siân, Velculescu, Victor E, Le, Dung T, Diaz, Jr, Luis A, Sausen, Mark

“…Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune…”
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Psychometric Properties of Performance-Based Functional Tests in Patients With Shoulder Pathologies: A Systematic Review and Meta-analysis by Nazari, Goris, Lu, Steve, MacDermid, Joy C., Azizi, Aziza, Stokes, Nicole, Hiller, Samantha, Kim, Alex, Akhavan, Kiarash

“…To identify, critically appraise, and synthesize the reported psychometric properties of shoulder performance-based functional tests in patients with shoulder…”
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CD4 T Cell-Dependent Rejection of Beta-2 Microglobulin Null Mismatch Repair-Deficient Tumors by Germano, Giovanni, Lu, Steve, Rospo, Giuseppe, Lamba, Simona, Rousseau, Benoit, Fanelli, Sonia, Stenech, Denise, Le, Dung T, Hays, John, Totaro, Maria Grazia, Amodio, Vito, Chilà, Rosaria, Mondino, Anna, Diaz, Jr, Luis A, Di Nicolantonio, Federica, Bardelli, Alberto

“…Inactivation of beta-2 microglobulin (B2M) is considered a determinant of resistance to immune checkpoint inhibitors (ICPi) in melanoma and lung cancers. In…”
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Rasch Analysis for the Knee Injury and Osteoarthritis Outcome Score Joint Replacement Version in Individuals Awaiting Total Knee Replacement Surgery by Mehta, Saurabh P, Jobes, Joshua, Parsemain, Chloe, Lu, Steve, Kelley, Kristie, Oliashirazi, Ali

“…The aim of this study was to verify the single-factor structure of the joint replacement version of the Knee Injury and Osteoarthritis Outcome Score (KOOS-JR)…”
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Cruciform DNA structure formed at short inverted repeats: A source of genetic instability in vivo by Mandke, Pooja P, Kompella, Pallavi, Lu, Steve, Wang, Guliang, Vasquez, Karen

“…Genomic instability is a major driving force for many human diseases including cancer. Certain mutation “hotspot” regions of the human genome are susceptible…”
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The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer by Mattox, Austin K, Douville, Christopher, Wang, Yuxuan, Popoli, Maria, Ptak, Janine, Silliman, Natalie, Dobbyn, Lisa, Schaefer, Joy, Lu, Steve, Pearlman, Alexander H, Cohen, Joshua D, Tie, Jeanne, Gibbs, Peter, Lahouel, Kamel, Bettegowda, Chetan, Hruban, Ralph H, Tomasetti, Cristian, Jiang, Peiyong, Chan, K C Allen, Lo, Yuk Ming Dennis, Papadopoulos, Nickolas, Kinzler, Kenneth W, Vogelstein, Bert

“…Cell-free DNA (cfDNA) concentrations from patients with cancer are often elevated compared with those of healthy controls, but the sources of this extra cfDNA…”
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Clinical, Functional and Radiographic Outcomes of Inverted-Bearing Reverse Shoulder Arthroplasty at Minimum Two Year Follow-up by Paccot, Daniel, Matheson, John, Lu, Steve, Al-Raiyes, Thamer, Drosdowech, Darren

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Rasch analysis of the firefighters' critical incident inventory questionnaire by Nazari, Goris, Lu, Steve, Packham, Tara, MacDermid, Joy C

“…The Critical Incident Inventory (CII) was developed to assess stressful exposures in firefighters and emergency service workers. The CII includes six…”
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