Search Results - "Lu, Shuyan"

Lysosomal adaptation: How cells respond to lysosomotropic compounds by Lu, Shuyan, Sung, Tae, Lin, Nianwei, Abraham, Robert T, Jessen, Bart A

“…Lysosomes are acidic organelles essential for degradation and cellular homoeostasis and recently lysosomes have been shown as signaling hub to respond to the…”
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The contribution of lysosomotropism to autophagy perturbation by Ashoor, Roshan, Yafawi, Rolla, Jessen, Bart, Lu, Shuyan

“…Autophagy refers to the catabolic process in eukaryotic cells that delivers cytoplasmic material to lysosomes for degradation. This highly conserved process is…”
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Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing by Yang, Song, Lu, Shuyan, Ren, Limei, Bian, Shuai, Zhao, Daqing, Liu, Meichen, Wang, Jiawen

“…Past studies suggested that ginseng extracts and ginseng-derived molecules exerted significant regulatory effects on skin. However, no reports have described…”
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Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors by Niessen, Sherry, Dix, Melissa M, Barbas, Sabrina, Potter, Zachary E, Lu, Shuyan, Brodsky, Oleg, Planken, Simon, Behenna, Douglas, Almaden, Chau, Gajiwala, Ketan S, Ryan, Kevin, Ferre, RoseAnn, Lazear, Michael R, Hayward, Matthew M, Kath, John C, Cravatt, Benjamin F

“…Patients with non-small cell lung cancers that have kinase-activating epidermal growth factor receptor (EGFR) mutations are highly responsive to first-…”
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20(S)-Ginsenoside Rg3 Promotes HeLa Cell Apoptosis by Regulating Autophagy by Bian, Shuai, Zhao, Yue, Li, Fangyu, Lu, Shuyan, Wang, Siming, Bai, Xueyuan, Liu, Meichen, Zhao, Daqing, Wang, Jiawen, Guo, Dean

“…20( )-Ginsenoside Rg3 (GRg3) has various bioactivities including anti-cancer effects and inhibition of autophagy. However, no reports have investigated the…”
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A high content screening assay for identifying lysosomotropic compounds by Nadanaciva, Sashi, Lu, Shuyan, Gebhard, David F., Jessen, Bart A., Pennie, William D., Will, Yvonne

“…Lysosomes are acidic organelles that are essential for the degradation of old organelles and engulfed microbes. Furthermore, lysosomes play a key role in cell…”
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Knockdown of p62/sequestosome enhances ginsenoside Rh2-induced apoptosis in cervical cancer HeLa cells with no effect on autophagy by Bian, Shuai, Zhao, Yue, Li, Fangyu, Lu, Shuyan, Yang, Song, Liu, Meichen, Wang, Siming, Zhao, Daqing, Zhang, Wei, Wang, Jiawen

“…p62/sequestosome is a multifunctional adaptor protein that participates in a wide variety of cellular processes. 20(S)-Ginsenoside Rh2 (G-Rh2) has various…”
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Microphysiological systems in early stage drug development: Perspectives on current applications and future impact by Kopec, Anna K., Yokokawa, Ryuji, Khan, Nasir, Horii, Ikuo, Finley, James E., Bono, Christine P., Donovan, Carol, Roy, Jessica, Harney, Julie, Burdick, Andrew D., Jessen, Bart, Lu, Shuyan, Collinge, Mark, Sadeghian, Ramin Banan, Derzi, Mazin, Tomlinson, Lindsay, Burkhardt, John E.

“…Microphysiological systems (MPS) are making advances to provide more standardized and predictive physiologically relevant responses to test articles in living…”
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Mechanistic investigation of imatinib-induced cardiac toxicity and the involvement of c-Abl kinase by Hu, Wenyue, Lu, Shuyan, McAlpine, Indrawan, Jamieson, Joseph D, Lee, Dong U, Marroquin, Lisa D, Heyen, Jonathan R, Jessen, Bart A

“…The Bcr-abl tyrosine kinase inhibitor imatinib mesylate is the frontline therapy for chronic myeloid leukemia. Imatinib has been reported to cause congestive…”
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Determination of 12 Mycotoxins in Seasoning Flour Products by QuEChERS-SPE-Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry by Ziting XU, Lihua HAO, Jing MA, Runxin WEI, Xiaoming LI, Wenting FAN, Shuyan LU

“…A method was developed for the residual quantity determination of 12 mycotoxins in seasoning flour products by QuEChERS-SPE-ultra performance liquid…”
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Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo by Yang, Song, Li, Fangyu, Lu, Shuyan, Ren, Limei, Bian, Shuai, Liu, Meichen, Zhao, Daqing, Wang, Siming, Wang, Jiawen

“…Panax ginseng C.A. Meyer is a type of herbal plant that has frequently been used in many Asian countries to treat a variety of diseases. Ginseng is considered…”
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Inter-laboratory evaluation of the bioluminescent Salmonella reverse mutation assay using 10 model chemicals by Ackerman, Joel, Sharma, Rahul, Hitchcock, Jonathan, Hayashi, Toshiaki, Nagai, Yoshikazu, Li, Shuanglian, Lu, Shuyan, Miret, Juan, Tang, Kim, Spence, Fiona, Aubrecht, Jiri

“…We have developed the bioluminescent Salmonella reverse mutation assay as a tool for detecting mutagenicity applicable for high-throughput screening of new…”
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Aluminum/Tin-doped UiO-66 as Lewis acid catalysts for enhanced glucose isomerization to fructose by Li, Yulin, Meng, Xiangyunxiu, Luo, Ruiwen, Zhou, Haonan, Lu, Shuyan, Yu, Shuning, Bai, Peng, Guo, Xianghai, Lyu, Jiafei

“…Glucose isomerization into fructose is the dominant reaction path for biomass conversion. Lewis acidic aluminum or tin were firstly impregnated in microporous…”
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20(S)-Ginsenoside Rh2-induced apoptosis and protective autophagy in cervical cancer cells by inhibiting AMPK/mTOR pathway by Bian, Shuai, Liu, Meichen, Yang, Song, Lu, Shuyan, Wang, Siming, Bai, Xueyuan, Zhao, Daqing, Wang, Jiawen

“…20(S)-Ginsenoside Rh2 (GRh2) has various biological activities including anticancer effects. However, no reports have investigated the connection between…”
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Effective isomerization of glucose to fructose by Sn-MFI/MCM-41 composites as Lewis acid catalysts by Lu, Shuyan, Lyu, Jiafei, Han, Xiwei, Bai, Peng, Guo, Xianghai

“…[Display omitted] Zeolites as heterogenous catalysts have continuously attracted researchers’ interest due to the potentials for industrial biomass conversion…”
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Numerical simulation of microscopic CO2 hydrate formation in sandy sediment with two-phase flow by Lu, Shuyan, Yamaguchi, Alan Junji, Kobayashi, Kaito, Sato, Toru, Tobase, Takaomi

“…•A simulation method for CO2 hydrate growth in two-phase flow was developed.•The effects of hydrate formation rate and flow speed on permeability were…”
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Phenotypic Characterization of Targeted Knockdown of Cyclin-Dependent Kinases in the Intestinal Epithelial Cells by Lu, Shuyan, Sung, Tae, Amaro, Marina, Hirakawa, Brad, Jessen, Bart, Hu, Wenyue

“…Abstract Cyclin-dependent kinases (CDKs) are serine/threonine kinases that regulate cell cycle and have been vigorously pursued as druggable targets for…”
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Improving technofunctional performance and emulsion stability of ginsenoside microcapsules by using maltodextrin-inulin/lactose composite wall materials by Yang, Tao, Han, Shanshan, Xu, Heying, Ye, Mengping, Liu, Tristan C., Liu, Jianguo, Lu, Shuyan, Liu, Chang, Liu, Yaowei, Zhou, Peng

“…This study prepared ginsenoside microcapsules with different wall materials (maltodextrin, inulin, lactose) by spray drying based on ginsenoside emulsions, and…”
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Abstract 99: Phenotypic characterization of knockdown of CDKs in the intestinal epithelial cells by Lu, Shuyan, Hu, Wenyue, Sung, Tae, Hirakawa, Brad, Amaro, Marina, Jessen, Bart

“…Abstract Cyclin-dependent kinases (CDKs) are serine/threonine kinases that bind to cyclins and together act as regulators of cell cycle progression. CDK…”
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Intestinal Toxicity in Rats Following Administration of CDK4/6 Inhibitors Is Independent of Primary Pharmacology by Thibault, Stephane, Hu, Wenyue, Hirakawa, Brad, Kalabat, Dalia, Franks, Tania, Sung, Tae, Khoh-Reiter, Su, Lu, Shuyan, Finkelstein, Martin, Jessen, Bart, Sacaan, Aida

“…Recently three different cyclin-dependent kinase 4 and 6 (CDK4/6) dual inhibitors were approved for the treatment of breast cancer (palbociclib, ribociclib,…”
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