Search Results - "Lu, Shaoyong"

Small Molecule Allosteric Modulators of G‑Protein-Coupled Receptors: Drug–Target Interactions by Lu, Shaoyong, Zhang, Jian

“…G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are most frequently targeted by therapeutic drugs. Allosteric modulators…”
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Antibiotics in the aquatic environments: A review of lakes, China by Liu, Xiaohui, Lu, Shaoyong, Guo, Wei, Xi, Beidou, Wang, Weiliang

“…The potential threat of antibiotics to the environment and human health has raised significant concerns in recent years. The consumption and production of…”
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Allosteric Modulator Discovery: From Serendipity to Structure-Based Design by Lu, Shaoyong, He, Xinheng, Ni, Duan, Zhang, Jian

“…Allosteric modulators bound to structurally diverse allosteric sites can achieve better pharmacological advantages than orthosteric ligands. The discovery of…”
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Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design by Lu, Shaoyong, He, Xinheng, Yang, Zhao, Chai, Zongtao, Zhou, Shuhua, Wang, Junyan, Rehman, Ashfaq Ur, Ni, Duan, Pu, Jun, Sun, Jinpeng, Zhang, Jian

“…G protein-coupled receptors (GPCRs) are the most common proteins targeted by approved drugs. A complete mechanistic elucidation of large-scale conformational…”
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The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B by Lu, Shaoyong, Jang, Hyunbum, Nussinov, Ruth, Zhang, Jian

“…Ras mediates cell proliferation, survival and differentiation. Mutations in K-Ras4B are predominant at residues G12, G13 and Q61. Even though all impair…”
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Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view by Lu, Shaoyong, Jang, Hyunbum, Gu, Shuo, Zhang, Jian, Nussinov, Ruth

“…Ras proteins are small GTPases, cycling between inactive GDP-bound and active GTP-bound states. Through these switches they regulate signaling that controls…”
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Ras Conformational Ensembles, Allostery, and Signaling by Lu, Shaoyong, Jang, Hyunbum, Muratcioglu, Serena, Gursoy, Attila, Keskin, Ozlem, Nussinov, Ruth, Zhang, Jian

“…Ras proteins are classical members of small GTPases that function as molecular switches by alternating between inactive GDP-bound and active GTP-bound states…”
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Removal and recovery of phosphate from water by lanthanum hydroxide materials by Xie, Jie, Wang, Zhe, Lu, Shaoyong, Wu, Deyi, Zhang, Zhenjia, Kong, Hainan

“…[Display omitted] •A lanthanum hydroxide adsorbent was prepared from waste alkaline solution.•The Langmuir adsorption maximum for phosphate reached…”
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Rational Design of Peptide-Based Inhibitors Disrupting Protein-Protein Interactions by Wang, Xuefei, Ni, Duan, Liu, Yaqin, Lu, Shaoyong

“…Protein-protein interactions (PPIs) are well-established as a class of promising drug targets for their implications in a wide range of biological processes…”
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A review on removal of organophosphorus pesticides in constructed wetland: Performance, mechanism and influencing factors by Liu, Tao, Xu, Shirong, Lu, Shaoyong, Qin, Pan, Bi, Bin, Ding, Haodong, Liu, Ying, Guo, Xiaochun, Liu, Xiaohui

“…The residues of organophosphorus pesticides (OPPs) have been widely detected in rivers, the gulf, and even groundwater and drinking water, which may pose a…”
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Harnessing Allostery: A Novel Approach to Drug Discovery by Lu, Shaoyong, Li, Shuai, Zhang, Jian

“…Allostery is the most direct and efficient way for regulation of biological macromolecule function, ranging from the control of metabolic mechanisms to signal…”
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Allosteric binding sites at the receptor–lipid bilayer interface: novel targets for GPCR drug discovery by Wang, Ying, Yu, Zhengtian, Xiao, Wen, Lu, Shaoyong, Zhang, Jian

“…•Allosteric GPCR drug discovery is gaining increasing attention.•Lipid bilayer plays a unique role in the allosteric sites of GPCRs.•The role of lipid bilayer…”
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Occurrence and fate of antibiotics and antibiotic resistance genes in typical urban water of Beijing, China by Liu, Xiaohui, Zhang, Guodong, Liu, Ying, Lu, Shaoyong, Qin, Pan, Guo, Xiaochun, Bi, Bin, Wang, Lei, Xi, Beidou, Wu, Fengchang, Wang, Weiliang, Zhang, Tingting

“…The pollution of antibiotics and antibiotic resistance genes (ARGs) has been highlighted on a global scale because of their serious threats to the environment…”
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Recent computational advances in the identification of allosteric sites in proteins by Lu, Shaoyong, Huang, Wenkang, Zhang, Jian

“…•Drug discovery in the field of allostery is gaining increasing attention.•Experimentally discovering allosteric sites in proteins remains a…”
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Profiles of antibiotic resistance genes in an inland salt-lake Ebinur Lake, Xinjiang, China: The relationship with antibiotics, environmental factors, and microbial communities by Wang, Yongqiang, Lu, Shaoyong, Liu, Xiaohui, Chen, Jing, Han, Maozhen, Wang, Zhi, Guo, Wei

“…Lakes in arid northwestern China, as the main pollutant-holding water bodies in the typical ecologically fragile areas, are facing the unknown risk of exposure…”
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Characterization of pharmaceutically active compounds in Dongting Lake, China: Occurrence, chiral profiling and environmental risk by Ma, Ruixue, Wang, Bin, Lu, Shaoyong, Zhang, Yizhe, Yin, Lina, Huang, Jun, Deng, Shubo, Wang, Yujue, Yu, Gang

“…Twenty commonly used pharmaceuticals including eight chiral drugs were investigated in Dongting Lake, China. The contamination level was relatively low on a…”
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Inhibitors of Ras-SOS Interactions by Lu, Shaoyong, Jang, Hyunbum, Zhang, Jian, Nussinov, Ruth

“…Activating Ras mutations are found in about 30 % of human cancers. Ras activation is regulated by guanine nucleotide exchange factors, such as the son of…”
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Sulfamethoxazole degradation by Pseudomonas silesiensis F6a isolated from bioelectrochemical technology-integrated constructed wetlands by Liu, Xiaohui, Chen, Jing, Liu, Ying, Wan, Zhengfen, Guo, Xiaochun, Lu, Shaoyong, Qiu, Dongru

“…The antibiotic-degrading ability and mechanism of the bacteria in the novel and ecological bioelectrochemical technology-integrated constructed wetlands (BICW)…”
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Comparison of 17β-Estradiol Adsorption on Corn Straw- and Dewatered Sludge-Biochar in Aqueous Solutions by Guo, Wei, Yue, Junhui, Zhao, Qian, Zhang, Li, Lu, Shaoyong

“…Removal of steroid hormones from aqueous environment is of prevailing concern because of their adverse impact on organisms. Using biochar derived from biomass…”
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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators by Lu, Shaoyong, Chen, Yingyi, Wei, Jiacheng, Zhao, Mingzhu, Ni, Duan, He, Xinheng, Zhang, Jian

“…The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase, sirtuin 6 (SIRT6) has attracted…”
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