Search Results - "Lu, Saien"

Progress in diagnosis and treatment of hypertension combined with left ventricular hypertrophy by Han, Yongjin, Li, Yanqiu, Wu, Zhen, Pei, Ying, Lu, Saien, Yu, Haijie, Sun, Yingxian, Zhang, Xueyao

“…Hypertension, a worldwide cardiovascular issue, is known to result in significant damage to the left ventricle. Left ventricular hypertrophy refers to an…”
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Construction and validation of a nomogram to predict left ventricular hypertrophy in low‐risk patients with hypertension by Zhang, Xueyao, He, Chuan, Lu, Saien, Yu, Haijie, Li, Guangxiao, Zhang, Pengyu, Sun, Yingxian

“…Electrocardiography (ECG) is an accessible diagnostic tool for screening patients with hypertensive left ventricular hypertrophy (LVH). However, its diagnostic…”
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The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response by Lu, Xinxin, Xu, Haiqi, Xu, Jiaqi, Lu, Saien, You, Shilong, Huang, Xinyue, Zhang, Naijin, Zhang, Lijun

“…E3 ubiquitin ligases, an important part of ubiquitin proteasome system, catalyze the covalent binding of ubiquitin to target substrates, which plays a role in…”
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Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A by Yin, Zeyu, You, Shilong, Zhang, Shu, Zhang, Linlin, Wu, Boquan, Huang, Xinyue, Lu, Saien, Cao, Liu, Zhang, Ying, Li, Da, Zhang, Xingang, Liu, Jingwei, Sun, Yingxian, Zhang, Naijin

“…As a widely used lipid-lowering drug in clinical practice, atorvastatin is widely recognized for its role in protecting vascular endothelium in the…”
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An unexpected role for BAG3 in regulating PARP1 ubiquitination in oxidative stress-related endothelial damage by Zhang, Naijin, Zhang, Ying, Miao, Wei, Shi, Chuning, Chen, Zihan, Wu, Boquan, Zou, Yuanming, Ma, Qiushi, You, Shilong, Lu, Saien, Huang, Xinyue, Liu, Jingwei, Xu, Jiaqi, Cao, Liu, Sun, Yingxian

“…Oxidative stress-associated endothelial damage is the initiation factor of cardiovascular disease, and protein posttranslational modifications play critical…”
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Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury by Zhang, Naijin, Zhang, Ying, Wu, Boquan, Wu, Shaojun, You, Shilong, Lu, Saien, Liu, Jingwei, Huang, Xinyue, Xu, Jiaqi, Cao, Liu, Sun, Yingxian

“…Poly(ADP-ribose) polymerase 1 (PARP1) has a major regulatory role in cardiovascular disease. However, inhibiting PARP1 activity does not significantly improve…”
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Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α by Wu, Shaojun, Zhang, Ying, You, Shilong, Lu, Saien, Zhang, Naijin, Sun, Yingxian

“…Septin4, a protein localized at mitochondrion, can promote cells apoptosis mainly by binding XIAP (X-linked inhibitors of apoptosis), however, nothing is known…”
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BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination by Zhang, Naijin, Zhang, Ying, Chen, Yong, Qian, Hao, Wu, Boquan, Lu, Saien, You, Shilong, Xu, Wancheng, Zou, Yuanming, Huang, Xinyue, Wang, Wenbin, Liu, Jingwei, Li, Da, Cao, Liu, Sun, Yingxian

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The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia by Lu, Xinxin, Huang, Xinyue, Xu, Haiqi, Lu, Saien, You, Shilong, Xu, Jiaqi, Zhan, Qianru, Dong, Chao, Zhang, Ning, Zhang, Ying, Cao, Liu, Zhang, Xingang, Zhang, Naijin, Zhang, Lijun

“…Acute lymphoblastic leukemia (ALL) has been a huge threat for people's health and finding effective target therapy is urgent and important. WWP2, as one of E3…”
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Septin4 as an autophagy modulator regulates Angiotensin-II mediated VSMCs proliferation and migration by Wang, Ning, Xu, Feng, Lu, Saien, Zhang, Naijin, Sun, Yingxian

“…Vascular smooth muscle cells (VSMCs) proliferation and migration play a fundamental role during the process of hypertensive angiopathy. Angiotensin-II (Ang-II)…”
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The role of SIRT2 in vascular‐related and heart‐related diseases: A review by Wu, Boquan, You, Shilong, Qian, Hao, Wu, Shaojun, Lu, Saien, Zhang, Ying, Sun, Yingxian, Zhang, Naijin

“…At present, cardiovascular disease is one of the important factors of human death, and there are many kinds of proteins involved. Sirtuins family proteins are…”
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α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure by Zhang, Naijin, Zhang, Ying, Xu, Jiaqi, Wang, Pengbo, Wu, Boquan, Lu, Saien, Lu, Xinxin, You, Shilong, Huang, Xinyue, Li, Mohan, Zou, Yuanming, Liu, Mengke, Zhao, Yuanhui, Sun, Guozhe, Wang, Wenbin, Geng, Danxi, Liu, Jingwei, Cao, Liu, Sun, Yingxian

“…The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contraction. However, the mechanism regulating this…”
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E3 Ubiquitin ligase NEDD4 family‑regulatory network in cardiovascular disease by Zhang, Ying, Qian, Hao, Wu, Boquan, You, Shilong, Wu, Shaojun, Lu, Saien, Wang, Pingyuan, Cao, Liu, Zhang, Naijin, Sun, Yingxian

“…Protein ubiquitination represents a critical modification occurring after translation. E3 ligase catalyzes the covalent binding of ubiquitin to the protein…”
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WWP2 regulates SIRT1‐STAT3 acetylation and phosphorylation involved in hypertensive angiopathy by Zhang, Ying, You, Shilong, Tian, Yichen, Lu, Saien, Cao, Liu, Sun, Yingxian, Zhang, Naijin

“…WWP2 is a HECT‐type E3 ubiquitin ligase that regulates various physiological and pathological activities by binding to different substrates, but its function…”
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Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive Nephropathy by Zhang, Ying, Zhang, Naijin, Zou, Yuanming, Song, Chunyu, Cao, Kexin, Wu, Boquan, You, Shilong, Lu, Saien, Wang, Dong, Xu, Jiaqi, Huang, Xinyue, Zhang, Pengyu, Fan, Zihao, Liu, Jingwei, Cheng, Zhongyi, Zhang, Zhe, Kong, Chuize, Cao, Liu, Sun, Yingxian

“…Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating podocyte apoptosis has…”
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Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation by Zhang, Naijin, Zhang, Ying, You, Shilong, Tian, Yichen, Lu, Saien, Cao, Liu, Sun, Yingxian

“…SIRT1 and STAT3 are key to human aortic vascular smooth muscle cells (HAVSMCs) proliferation, migration and phenotypic transformation, but the regulatory…”
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Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive Nephropathy by Zhang, Ying, Zhang, Naijin, Zou, Yuanming, Song, Chunyu, Cao, Kexin, Wu, Boquan, You, Shilong, Lu, Saien, Wang, Dong, Xu, Jiaqi, Huang, Xinyue, Zhang, Pengyu, Fan, Zihao, Liu, Jingwei, Cheng, Zhongyi, Zhang, Zhe, Kong, Chuize, Cao, Liu, Sun, Yingxian

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The Role of BRG1 in Antioxidant and Redox Signaling by Zhang, Naijin, Sun, Yingxian, Wu, Boquan, Wu, Shaojun, Qian, Hao, Xu, Jiaqi, Zhang, Ying, You, Shilong, Lu, Saien

“…Redox homeostasis is regulated by critical molecules that modulate antioxidant and redox signaling (ARS) within the cell. Imbalances among these molecules can…”
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DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53 by Wang, Pengbo, Wu, Boquan, You, Shilong, Lu, Saien, Xiong, Shengjun, Zou, Yuanming, Jia, Pengyu, Guo, Xiaofan, Zhang, Ying, Cao, Liu, Sun, Yingxian, Zhang, Naijin

“…DNA polymerase gamma (PolG) is the major polymerase of mitochondrial DNA (mtDNA) and essential for stabilizing mitochondrial function. Vascular calcification…”
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