Search Results - "Lu, Saideng"

Mitochondrial quality control in intervertebral disc degeneration by Song, Yu, Lu, Saideng, Geng, Wen, Feng, Xiaobo, Luo, Rongjin, Li, Gaocai, Yang, Cao

“…Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the human lifespan that can increase the risk of low back pain. More…”
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Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy by Li, Gaocai, Song, Yu, Liao, Zhiwei, Wang, Kun, Luo, Rongjin, Lu, Saideng, Zhao, Kangcheng, Feng, Xiaobo, Liang, Hang, Ma, Liang, Wang, Bingjin, Ke, Wencan, Yin, Huipeng, Zhan, Shengfeng, Li, Shuai, Wu, Xinghuo, Zhang, Yukun, Yang, Cao

“…N6 methyladenosine (m 6 A) is one of the most prevalent epitranscriptomic modifications of mRNAs, and plays a critical role in various bioprocesses…”
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O-GlcNAc transferase regulates intervertebral disc degeneration by targeting FAM134B-mediated ER-phagy by Luo, Rongjin, Li, Gaocai, Zhang, Weifei, Liang, Huaizhen, Lu, Saideng, Cheung, Jason Pui Yin, Zhang, Teng, Tu, Ji, Liu, Hui, Liao, Zhiwei, Ke, Wencan, Wang, Bingjin, Song, Yu, Yang, Cao

“…Both O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) and endoplasmic reticulum-phagy (ER-phagy) are well-characterized conserved adaptive regulatory…”
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Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells by Ma, Liang, Li, Gaocai, Wang, Kun, Song, Yu, Li, Shuai, Wu, Xinghuo, Yang, Cao, Zhang, Yukun, Liao, Zhiwei, Wang, Bingjin, Luo, Rongjin, Hua, Wenbin, Feng, Xiaobo, Wang, Juntan, Cheng, Zhangrong, Xiang, Qian, Lu, Saideng

“…Intervertebral disc degeneration (IDD) is one of the most common chronic degenerative musculoskeletal disorders. Oxidative stress-induced apoptosis of the…”
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Minimally Invasive Surgery Oblique Lumbar Interbody Debridement and Fusion for the Treatment of Lumbar Spondylodiscitis by Wang, Bingjin, Chen, Chao, Hua, Wenbin, Ke, Wencan, Lu, Saideng, Zhang, Yukun, Zeng, Xianlin, Yang, Cao

“…Objective To evaluate the efficacy and feasibility of minimally invasive oblique lumbar interbody debridement and fusion for the treatment of conservatively…”
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Biomechanical Evaluation of Different Surgical Approaches for the Treatment of Adjacent Segment Diseases After Primary Anterior Cervical Discectomy and Fusion: A Finite Element Analysis by Ke, Wencan, Chen, Chao, Wang, Bingjin, Hua, Wenbin, Lu, Saideng, Song, Yu, Luo, Rongjin, Liao, Zhiwei, Li, Gaocai, Ma, Liang, Shi, Yunsong, Wang, Kun, Li, Shuai, Wu, Xinghuo, Zhang, Yukun, Yang, Cao

“…Symptomatic adjacent segment disease (ASD) is a common challenge after anterior cervical discectomy and fusion (ACDF). The objective of this study was to…”
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CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3 by Xiang, Qian, Kang, Liang, Zhao, Kangcheng, Wang, Juntan, Hua, Wenbin, Song, Yu, Feng, Xiaobo, Li, Gaocai, Lu, Saideng, Wang, Kun, Yang, Cao, Zhang, Yukun

“…Circular RNAs (circRNAs) have been increasingly demonstrated to play critical roles in the pathogenesis of various human diseases. Intervertebral disk…”
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Biomechanical Evaluation of Transforaminal Lumbar Interbody Fusion and Oblique Lumbar Interbody Fusion on the Adjacent Segment: A Finite Element Analysis by Wang, Bingjin, Hua, Wenbin, Ke, Wencan, Lu, Saideng, Li, Xingsheng, Zeng, Xianlin, Yang, Cao

“…To analyze the biomechanical changes of lumbar adjacent segment by comparing the biomechanics after the surgery of transforaminal lumbar interbody fusion…”
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Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration by Liao, Zhiwei, Li, Shuai, Lu, Saideng, Liu, Hui, Li, Gaocai, Ma, Liang, Luo, Rongjin, Ke, Wencan, Wang, Bingjin, Xiang, Qian, Song, Yu, Feng, Xiaobo, Zhang, Yukun, Wu, Xinghuo, Hua, Wenbin, Yang, Cao

“…Extracellular vesicles (EVs) are extracellular nanovesicles that deliver diverse cargoes to the cell and participate in cell communication. Mesenchymal stem…”
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Berberine ameliorates oxidative stress-induced apoptosis by modulating ER stress and autophagy in human nucleus pulposus cells by Luo, Rongjin, Liao, Zhiwei, Song, Yu, Yin, Huipeng, Zhan, Shengfeng, Li, Gaocai, Ma, Liang, Lu, Saideng, Wang, Kun, Li, Shuai, Zhang, Yukun, Yang, Cao

“…Nucleus pulposus (NP) cell apoptosis induced by oxidative stress is known to be closely involved in the pathogenesis of intervertebral disc (IVD) degeneration…”
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Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo by Lu, Saideng, Song, Yu, Luo, Rongjin, Li, Shuai, Li, Gaocai, Wang, Kun, Liao, Zhiwei, Wang, Bingjin, Ke, Wencan, Xiang, Qian, Chen, Chao, Wu, Xinghuo, Zhang, Yukun, Ling, Li, Yang, Cao

“…Ferroptosis is a specialized form of regulated cell death that is charactered by iron-dependent lethal lipid peroxidation, a process associated with multiple…”
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Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration by Wang, Bingjin, Ke, Wencan, Wang, Kun, Li, Gaocai, Ma, Liang, Lu, Saideng, Xiang, Qian, Liao, Zhiwei, Luo, Rongjin, Song, Yu, Hua, Wenbin, Wu, Xinghuo, Zhang, Yukun, Zeng, Xianlin, Yang, Cao

“…Mechanical stimulation plays a crucial part in the development of intervertebral disc degeneration (IDD). Extracellular matrix (ECM) stiffness, which is a…”
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Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats by Luo, Rongjin, Song, Yu, Liao, Zhiwei, Yin, Huipeng, Zhan, Shengfeng, Wang, Kun, Li, Shuai, Li, Gaocai, Ma, Liang, Lu, Saideng, Zhang, Yukun, Yang, Cao

“…Previous studies identified advanced glycation end products (AGEs) accumulation in the intervertebral disc (IVD) as an essential risk factor associated with…”
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Clinically suspected fibrocartilaginous embolism: a case report and literature review by Ke, Wencan, Chen, Chao, Li, Shuai, Wang, Bingjin, Lu, Saideng, Yang, Cao

“…Spinal cord infarction (SCI) occurs rarely and is characterized by abrupt onset of neck or back pain and neurologic deterioration. Fibrocartilaginous embolism…”
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Biomechanical evaluation of anterior and posterior lumbar surgical approaches on the adjacent segment: a finite element analysis by Wang, Bingjin, Ke, Wencan, Hua, Wenbin, Lu, Saideng, Zeng, Xianlin, Yang, Cao

“…The purpose of this study was to use models of spine to compare range of motion and intradiscal pressure of adjacent segments performing anterior and/or…”
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Biomechanical Evaluation of the Sacral Slope on the Adjacent Segment in Transforaminal Lumbar Interbody Fusion: A Finite Element Analysis by Ke, Wencan, Wang, Bingjin, Hua, Wenbin, Lu, Saideng, Li, Xingsheng, Yang, Cao

“…Spinopelvic sagittal parameters have a significant influence on adjacent segment degeneration (ASD) after fusion surgery. The association between ASD and…”
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The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells by Ke, Wencan, Wang, Bingjin, Hua, Wenbin, Song, Yu, Lu, Saideng, Luo, Rongjin, Li, Gaocai, Wang, Kun, Liao, Zhiwei, Xiang, Qian, Li, Shuai, Wu, Xinghuo, Zhang, Yukun, Yang, Cao

“…Objectives Inappropriate or excessive compression applied to intervertebral disc (IVD) contributes substantially to IVD degeneration. The actomyosin system…”
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FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells by Luo, Rongjin, Li, Shuai, Li, Gaocai, Lu, Saideng, Zhang, Weifeng, Liu, Hui, Lei, Jie, Ma, Liang, Ke, Wencan, Liao, Zhiwei, Wang, Bingjin, Song, Yu, Wang, Kun, Zhang, Yukun, Yang, Cao

“…Previous studies have established the pathogenic role of advanced glycation end products (AGEs) accumulation in intervertebral disc degeneration (IDD)…”
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Percutaneous posterior full-endoscopic cervical foraminotomy and discectomy: a finite element analysis and radiological assessment by Ke, Wencan, Zhi, Jinggang, Hua, Wenbin, Wang, Bingjin, Lu, Saideng, Fan, Lina, Li, Li, Yang, Cao

“…Percutaneous posterior full-endoscopic cervical foraminotomy and discectomy (PECFD) is recognized as a safe, effective, and minimally invasive treatment for…”
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Clinically suspected fibrocartilaginous embolism: a case report and literature review by Ke, Wencan, Chen, Chao, Li, Shuai, Wang, Bingjin, Lu, Saideng, Yang, Cao

“…Spinal cord infarction (SCI) occurs rarely and is characterized by abrupt onset of neck or back pain and neurologic deterioration. Fibrocartilaginous embolism…”
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