Search Results - "Lu, Lily D"

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants by Tietjen, Ian, Cassel, Joel, Register, Emery T, Zhou, Xiang Yang, Messick, Troy E, Keeney, Frederick, Lu, Lily D, Beattie, Karren D, Rali, Topul, Tebas, Pablo, Ertl, Hildegund C. J, Salvino, Joseph M, Davis, Rohan A, Montaner, Luis J

“…Antivirals are urgently needed to combat the global SARS-CoV-2/COVID-19 pandemic, supplement existing vaccine efforts, and target emerging SARS-CoV-2 variants…”
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Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2 by Lu, Lily D, Stump, Kristine L, Wallace, Nate H, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Benjamin J, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M

“…Accumulating evidence suggests that autoreactive plasma cells play an important role in systemic lupus erythematosus (SLE). In addition, several…”
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Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer by Seavey, Matthew M, Lu, Lily D, Stump, Kristine L, Wallace, Nate H, Hockeimer, William, O'Kane, Teresa M, Ruggeri, Bruce A, Dobrzanski, Pawel

“…Constitutively activated STAT3 and STAT5 are expressed in a wide variety of human malignancies including solid and hematopoietic cancers and often correlate…”
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A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis by Stump, Kristine L, Lu, Lily D, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Ben J, Angeles, Thelma S, Albom, Mark S, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M

“…Janus kinase 2 (JAK2) is involved in the downstream activation of signal transducer and activator of transcription 3 (STAT3) and STAT5 and is responsible for…”
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The In-Cell Western immunofluorescence assay to monitor PROTAC mediated protein degradation by Lu, Lily D, Salvino, Joseph M

“…The In-Cell Western plate-based immunofluorescence assay is a useful methodology for monitoring protein levels and provides a facile moderate through-put…”
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Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE by Seavey, Matthew M., Lu, Lily D., Stump, Kristine L., Wallace, Nate H., Ruggeri, Bruce A.

“…Current therapies for late-stage systemic lupus erythematosus (SLE) are limited to cytotoxic agents. Delanzomib (CEP-18770) is an orally active, reversible P2…”
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Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: Identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test by Tripathy, Rabindranath, McHugh, Robert J., Bacon, Edward R., Salvino, Joseph M., Morton, George C., Aimone, Lisa D., Huang, Zeck, Mathiasen, Joanne R., DiCamillo, Amy, Huffman, Mark J., McKenna, Beth A., Kopec, Karla, Lu, Lily D., Qian, Jie, Angeles, Thelma S., Connors, Thomas, Spais, Chrysanthe, Holskin, Beverly, Duzic, Emir, Schaffhauser, Hervé, Rossé, Gerard C.

“…Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine6 (5-HT6) receptor…”
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Chemical-inducible, ecdysone receptor-based gene expression system for plants by PADIDAM, Malla, GORE, Michael, LU, D. Lily, SMIRNOVA, Olga

“…We have developed an inducible gene expression system with potential for field application using the ecdysone receptor (EcR) from the spruce budworm and the…”
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Novel method of monitoring trace cytokines and activated STAT molecules in the paws of arthritic mice using multiplex bead technology by Lu, Lily D, Stump, Kristine L, Seavey, Matthew M

“…The use of mouse models to study human disease provides useful data that can provide support for research projects or an existing drug discovery program. How…”
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Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities by SCHAFFHAUSER, Hervé, MATHIASEN, Joanne R, DICAMILLO, Amy, HUFFMAN, Mark J, LU, Lily D, MCKENNA, Beth A, JIE QIAN, MARINO, Michael J

“…Dimebolin (Dimebon), is a non-selective antihistamine approved in Russia for the treatment of allergy. Recently, this drug has been shown to be neuroprotective…”
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Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists by Sundar, Babu G., Bailey, Thomas R., Dunn, Derek D., Bacon, Edward R., Salvino, Joseph M., Morton, George C., Aimone, Lisa D., Zeqi, Huang, Mathiasen, Joanne R., Dicamillo, Amy, Huffman, Mark J., McKenna, Beth A., Kopec, Karla, Lu, Lily D., Brown, Rebecca, Qian, Jie, Angeles, Thelma, Connors, Thomas, Spais, Chrysanthe, Holskin, Beverly, Galinis, Deborah, Duzic, Emir, Schaffhauser, Herve, Rosse, Gerard C.

“…h5-HT6R Ki=4.4nM; h5-HT6R cAMP IC50=9.8nM; estimated rat % F=36; brain/plasma: 2. 7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel…”
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Animal models of systemic lupus erythematosus (SLE) and ex vivo assay design for drug discovery by Seavey, Matthew M, Lu, Lily D, Stump, Kristine L

“…Systemic Lupus Erythematosus (SLE) is a debilitating and often fatal autoimmune disease that involves multiple organ systems. It can develop for years before…”
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Dimebolin is a 5-HT sub(6) antagonist with acute cognition enhancing activities by Schaffhauser, Herve, Mathiasen, Joanne R, DiCamillo, Amy, Huffman, Mark J, Lu, Lily D, McKenna, Beth A, Qian, Jie, Marino, Michael J

“…Dimebolin (Dimebon[TM]), is a non-selective antihistamine approved in Russia for the treatment of allergy. Recently, this drug has been shown to be…”
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Dimebolin is a 5-HT 6 antagonist with acute cognition enhancing activities by Schaffhauser, Hervé, Mathiasen, Joanne R., DiCamillo, Amy, Huffman, Mark J., Lu, Lily D., McKenna, Beth A., Qian, Jie, Marino, Michael J.

“…Dimebolin (Dimebon™), is a non-selective antihistamine approved in Russia for the treatment of allergy. Recently, this drug has been shown to be…”
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