Search Results - "Lu, Lihui"

Control of locomotor speed, arousal, and hippocampal theta rhythms by the nucleus incertus by Lu, Lihui, Ren, Yuqi, Yu, Tao, Liu, Zhixiang, Wang, Sice, Tan, Lubin, Zeng, Jiawei, Feng, Qiru, Lin, Rui, Liu, Yang, Guo, Qingchun, Luo, Minmin

“…Navigation requires not only the execution of locomotor programs but also high arousal and real-time retrieval of spatial memory that is often associated with…”
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Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe by Li, Lizhu, Lu, Lihui, Ren, Yuqi, Tang, Guo, Zhao, Yu, Cai, Xue, Shi, Zhao, Ding, He, Liu, Changbo, Cheng, Dali, Xie, Yang, Wang, Huachun, Fu, Xin, Yin, Lan, Luo, Minmin, Sheng, Xing

“…Optogenetic methods provide efficient cell-specific modulations, and the ability of simultaneous neural activation and inhibition in the same brain region of…”
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BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes by Ma, Li, Wang, Jianwei, Zhang, Yongping, Fang, Fang, Ling, Jing, Chu, Xinran, Zhang, Zimu, Tao, Yanfang, Li, Xiaolu, Tian, Yuanyuan, Li, Zhiheng, Sang, Xu, Zhang, Kunlong, Lu, Lihui, Wan, Xiaomei, Chen, Yanling, Yu, Juanjuan, Zhuo, Ran, Wu, Shuiyan, Lu, Jun, Pan, Jian, Hu, Shaoyan

“…Acute myeloid leukemia (AML) is a highly cancerous and aggressive hematologic disease with elevated levels of drug resistance and relapse resulting in high…”
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Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK) by Ott, Gregory R, Cheng, Mangeng, Learn, Keith S, Wagner, Jason, Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew, Mesaros, Eugen F, Ghose, Arup K, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Dobrzanski, Pawel, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin, Huang, Zeqi, Aimone, Lisa D, Bruckheimer, Elizabeth, Anderson, Nathan, Friedman, Jay, Fernandez, Sandra V, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D

“…Analogues structurally related to anaplastic lymphoma kinase (ALK) inhibitor 1 were optimized for metabolic stability. The results from this endeavor not only…”
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A Novel BRD Family PROTAC Inhibitor dBET1 Exerts Great Anti-Cancer Effects by Targeting c-MYC in Acute Myeloid Leukemia Cells by Zhang, Kunlong, Gao, Li, Wang, Jianwei, Chu, Xinran, Zhang, Zimu, Zhang, Yongping, Fang, Fang, Tao, Yanfang, Li, Xiaolu, Tian, Yuanyuan, Li, Zhiheng, Sang, Xu, Ma, Li, Lu, Lihui, Chen, Yanling, Yu, Juanjuan, Zhuo, Ran, Wu, Shuiyan, Pan, Jian, Hu, Shaoyan

“…Acute myeloid leukemia (AML) represents an aggressive hematopoietic malignancy with a prognosis inferior to that of other leukemias. Recent targeted therapies…”
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LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1 by Lu, Lihui, Wang, Jianwei, Fang, Fang, Guo, Ailian, Jiang, Shuting, Tao, Yanfang, Zhang, Yongping, Li, Yan, Zhang, Kunlong, Zhang, Zimu, Zhuo, Ran, Chu, Xinran, Li, Xiaolu, Tian, Yuanyuan, Ma, Li, Sang, Xu, Chen, Yanling, Yu, Juanjuan, Yang, Yang, Cao, Haibo, Gao, Jizhao, Lu, Jun, Hu, Shaoyan, Pan, Jian, He, Hailong

“…One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant genes, such as…”
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BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia by Sang, Xu, Zhang, Yongping, Fang, Fang, Gao, Li, Tao, Yanfang, Li, Xiaolu, Zhang, Zimu, Wang, Jianwei, Tian, Yuanyuan, Li, Zhiheng, Yao, Di, Wu, Yumeng, Chu, Xinran, Zhang, Kunlong, Ma, Li, Lu, Lihui, Chen, Yanling, Yu, Juanjuan, Zhuo, Ran, Wu, Shuiyan, Zhang, Zhen, Pan, Jian, Hu, Shaoyan

“…Background. AML (acute myeloid leukemia) is a common hematological malignancy in children with poor treatment effects and poor prognosis. Recent studies have…”
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Luteolin-7-O-β-d-Glucuronide Attenuated Cerebral Ischemia/Reperfusion Injury: Involvement of the Blood-Brain Barrier by Fan, Xing, Song, Jintao, Zhang, Shuting, Lu, Lihui, Lin, Fang, Chen, Yu, Li, Shichang, Jin, Xinxin, Wang, Fang

“…Ischemic stroke is a common cerebrovascular disease with high mortality, high morbidity, and high disability. Cerebral ischemia/reperfusion injury seriously…”
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Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1 by Zhang, Kunlong, Lu, Jun, Fang, Fang, Zhang, Yongping, Yu, Juanjuan, Tao, Yanfang, liu, Wenyuan, Lu, Lihui, Zhang, Zimu, Chu, Xinran, Wang, Jianwei, Li, Xiaolu, Tian, Yuanyuan, Li, Zhiheng, Li, Qian, Sang, Xu, Ma, Li, Wang, Ningling, Pan, Jian, Hu, Shaoyan

“…Background. Arising from T progenitor cells, T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor, accounting for 15% of…”
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BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3 by Ma, Li, Wang, Jianwei, Yang, Yang, Lu, Jun, Ling, Jing, Chu, Xinran, Zhang, Zimu, Tao, Yanfang, Li, Xiaolu, Tian, Yuanyuan, Li, Zhiheng, Zhang, Yongping, Sang, Xu, Lu, Lihui, Wan, Xiaomei, Zhang, Kunlong, Chen, Yanling, Yu, Juanjuan, Zhuo, Ran, Wu, Shuiyan, Pan, Jian, Zhou, Xiuxia, Hu, Yixin, Hu, Shaoyan

“…INTRODUCTIONB-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent malignant tumor affecting children. While the majority of B-ALL patients (90%)…”
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Tracking the timing and nature of protolith, metamorphism, and partial melting of tourmaline‐bearing migmatites by zircon U–Pb and Hf isotopic compositions in the Yuka terrane, North Qaidam UHP metamorphic belt by Gao, Shunbao, Chen, Xin, Xu, Rongke, Cai, Pengjie, Lu, Lihui, Hou, Weidong, Guo, Xianzheng, Liu, Y.

“…An integrated study using cathodoluminescence (CL) images, U–Pb geochronology, and Hf isotopic characterization of zircons was performed on migmatites from the…”
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Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase by Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew A, Cheng, Mangeng, Quail, Matthew, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Haltiwanger, R. Curtis, Wells-Knecht, Kevin, Ott, Gregory R, Ghose, Arup K, Ator, Mark A, Ruggeri, Bruce, Dorsey, Bruce D

“…Anaplastic lymphoma kinase (ALK) is a promising therapeutic target for the treatment of cancer, supported by considerable favorable preclinical and clinical…”
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Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models by Mesaros, Eugen F., Burke, Jason P., Parrish, Jonathan D., Dugan, Benjamin J., Anzalone, Andrew V., Angeles, Thelma S., Albom, Mark S., Aimone, Lisa D., Quail, Matthew R., Wan, Weihua, Lu, Lihui, Huang, Zeqi, Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng, Ott, Gregory R., Dorsey, Bruce D.

“…The synthesis and biological evaluation of potent and selective anaplastic lymphoma kinase (ALK) inhibitors from a novel class of 2,4-diaminopyrimidines,…”
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Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells by Wan, Weihua, Albom, Mark S., Lu, Lihui, Quail, Matthew R., Becknell, Nadine C., Weinberg, Linda R., Reddy, Dandu R., Holskin, Beverly P., Angeles, Thelma S., Underiner, Ted L., Meyer, Sheryl L., Hudkins, Robert L., Dorsey, Bruce D., Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng

“…The roles of aberrant expression of constitutively active ALK chimeric proteins in the pathogenesis of anaplastic large-cell lymphoma (ALCL) have been well…”
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Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors by Mesaros, Eugen F, Thieu, Tho V, Wells, Gregory J, Zificsak, Craig A, Wagner, Jason C, Breslin, Henry J, Tripathy, Rabindranath, Diebold, James L, McHugh, Robert J, Wohler, Ashley T, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Huang, Zeqi, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin J, Aimone, Lisa D, Cheng, Mangeng, Ator, Mark A, Ott, Gregory R, Dorsey, Bruce D

“…Chemical strategies to mitigate cytochrome P450-mediated bioactivation of novel 2,7-disubstituted pyrrolo­[2,1-f]­[1,2,4]­triazine ALK inhibitors are described…”
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ALK Mutants in the Kinase Domain Exhibit Altered Kinase Activity and Differential Sensitivity to Small Molecule ALK Inhibitors by Lu, Lihui, Ghose, Arup K, Quail, Matthew R, Albom, Mark S, Durkin, John T, Holskin, Beverly P, Angeles, Thelma S, Meyer, Sheryl L, Ruggeri, Bruce A, Cheng, Mangeng

“…Abnormal expression of constitutively active anaplastic lymphoma kinase (ALK) chimeric proteins in the pathogenesis of anaplastic large-cell lymphoma (ALCL) is…”
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Gas sensing based on metal-organic frameworks: Concepts, functions, and developments by Zhang, Rui, Lu, Lihui, Chang, Yangyang, Liu, Meng

“…Effective detection of pollutant gases is vital for protection of natural environment and human health. There is an increasing demand for sensing devices that…”
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Chemical recycling technologies for PVC waste and PVC-containing plastic waste: A review by Lu, Lihui, Li, Weiming, Cheng, Ying, Liu, Meng

“…•The types and challenges of PVC waste management are discussed.•Dehydrochlorination and dechlorination of PVC are reviewed.•Recent progress in the chemical…”
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Keying behavior of gravity installed plate anchor in clay by Liu, Jun, Lu, Lihui, Hu, Yuxia

“…Gravity installed plate anchor (GIPLA) is made mainly of steel plates. It features a swivel mooring arm located close to the anchor tip. Its more complex…”
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Biohydrogen production from brown algae fermentation: Relationship between substrate reduction degree and hydrogen production by Li, Weiming, Lu, Lihui, Cheng, Chi, Ren, Nanqi, Yang, Shang-Tian, Liu, Meng

“…[Display omitted] •H2 production of seaweed hydrolysate was studied with C. tyrobutyricum.•Acetate assimilation significantly promotes mannitol digestion and…”
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