Search Results - "Lu, Li‐Fan"

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways by Zhao, Yunlong, Lee, Calvin K., Lin, Chia-Hao, Gassen, Rodrigo B., Xu, Xiaozheng, Huang, Zhe, Xiao, Changchun, Bonorino, Cristina, Lu, Li-Fan, Bui, Jack D., Hui, Enfu

“…Combined immunotherapy targeting the immune checkpoint receptors cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1), or…”
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Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity by Cho, Sunglim, Dong, Jiayi, Lu, Li‐Fan

“…Summary T cells are crucial to generate an effective response against numerous invading microbial pathogens and play a pivotal role in tumor surveillance and…”
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MicroRNA in the immune system, microRNA as an immune system by Lu, Li-Fan, Liston, Adrian

“…The advent of microRNA has potentially uncovered a new level of complexity to be considered for every biological process. Through the modulation of…”
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Conditional Gene-Targeting in Mice: Problems and Solutions by Becher, Burkhard, Waisman, Ari, Lu, Li-Fan

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An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses by Mann, Mati, Mehta, Arnav, Zhao, Jimmy L., Lee, Kevin, Marinov, Georgi K., Garcia-Flores, Yvette, Lu, Li-Fan, Rudensky, Alexander Y., Baltimore, David

“…The innate inflammatory response must be tightly regulated to ensure effective immune protection. NF-κB is a key mediator of the inflammatory response, and its…”
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In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation by Liao, Hsin-Kai, Hatanaka, Fumiyuki, Araoka, Toshikazu, Reddy, Pradeep, Wu, Min-Zu, Sui, Yinghui, Yamauchi, Takayoshi, Sakurai, Masahiro, O’Keefe, David D., Núñez-Delicado, Estrella, Guillen, Pedro, Campistol, Josep M., Wu, Cheng-Jang, Lu, Li-Fan, Esteban, Concepcion Rodriguez, Izpisua Belmonte, Juan Carlos

“…Current genome-editing systems generally rely on inducing DNA double-strand breaks (DSBs). This may limit their utility in clinical therapies, as unwanted…”
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An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice by Wen, Liang, Xin, Bing, Wu, Panyisha, Lin, Chia‐Hao, Peng, Chuanhui, Wang, Gaowei, Lee, Jin, Lu, Li‐Fan, Feng, Gen‐Sheng

“…Immunotherapy with checkpoint inhibitors for liver cancer, while active in many clinical trials worldwide, may have uncertain outcomes due to the unique…”
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Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses by Lu, Li-Fan, Boldin, Mark P., Chaudhry, Ashutosh, Lin, Ling-Li, Taganov, Konstantin D., Hanada, Toshikatsu, Yoshimura, Akihiko, Baltimore, David, Rudensky, Alexander Y.

“…Foxp3 + regulatory T (Treg) cells maintain immune homeostasis by limiting different types of inflammatory responses. Here, we report that miR-146a, one of the…”
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TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases by Yang, Bi-Huei, Wang, Ke, Wan, Shuo, Liang, Yan, Yuan, Xiaomei, Dong, Yi, Cho, Sunglim, Xu, Wanqing, Jepsen, Kristen, Feng, Gen-Sheng, Lu, Li-Fan, Xue, Hai-Hui, Fu, Wenxian

“…CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse…”
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Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b by Cho, Sunglim, Lee, Hyang-Mi, Yu, I-Shing, Choi, Youn Soo, Huang, Hsi-Yuan, Hashemifar, Somaye Sadat, Lin, Ling-Li, Chen, Mei-Chi, Afanasiev, Nikita D., Khan, Aly Azeem, Lin, Shu-Wha, Rudensky, Alexander Y., Crotty, Shane, Lu, Li-Fan

“…Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal…”
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A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner by Lu, Li-Fan, Gasteiger, Georg, Yu, I-Shing, Chaudhry, Ashutosh, Hsin, Jing-Ping, Lu, Yuheng, Bos, Paula D., Lin, Ling-Li, Zawislak, Carolyn L., Cho, Sunglim, Sun, Joseph C., Leslie, Christina S., Lin, Shu-Wha, Rudensky, Alexander Y.

“…MicroRNA (miRNA)-dependent regulation of gene expression confers robustness to cellular phenotypes and controls responses to extracellular stimuli. Although a…”
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Editorial: Regulators of a Regulator: Post-Transcriptional Regulation in Tregs by Zhou, Xuyu, Lu, Li-Fan

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Mast cells are essential intermediaries in regulatory T-cell tolerance by Van Snick, Jacques, Noelle, Randolph J, Gondek, David C, Lind, Evan F, Strom, Terry B, Zheng, Xin Xiao, Gleeson, Michael W, Pino-Lagos, Karina, Scott, Zachary A, Bennett, Kathy A, Lu, Li-Fan, Reed, Jennifer L, Coyle, Anthony J

“…Contrary to the proinflammatory role of mast cells in allergic disorders, the results obtained in this study establish that mast cells are essential in…”
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Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression by Li, Lu-Fan, Yang, Jie, Ma, Shi-Ping, Qu, Rong

“…Growing evidence indicates that glia atrophy contributes to the pathophysiology and the pathogenesis of major depressive disorder. Magnolol is the main…”
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MicroRNAs and Their Targetomes in Tumor-Immune Communication by Cho, Sunglim, Tai, Jesse W, Lu, Li-Fan

“…The development of cancer is a complex and dynamically regulated multiple-step process that involves many changes in gene expression. Over the last decade,…”
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T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow by Glatman Zaretsky, Arielle, Konradt, Christoph, Dépis, Fabien, Wing, James B., Goenka, Radhika, Atria, Daniela Gomez, Silver, Jonathan S., Cho, Sunglim, Wolf, Amaya I., Quinn, William J., Engiles, Julie B., Brown, Dorothy C., Beiting, Daniel, Erikson, Jan, Allman, David, Cancro, Michael P., Sakaguchi, Shimon, Lu, Li-Fan, Benoist, Christophe O., Hunter, Christopher A.

“…Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies after infection or vaccination, but questions remain about the…”
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Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance by Klann, Jane E, Kim, Stephanie H, Remedios, Kelly A, He, Zhaoren, Metz, Patrick J, Lopez, Justine, Tysl, Tiffani, Olvera, Jocelyn G, Ablack, Jailal N, Cantor, Joseph M, Boland, Brigid S, Yeo, Gene, Zheng, Ye, Lu, Li-Fan, Bui, Jack D, Ginsberg, Mark H, Petrich, Brian G, Chang, John T

“…Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane…”
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A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses by Cho, Sunglim, Wu, Cheng-Jang, Nguyen, Duc T, Lin, Ling-Li, Chen, Mei-Chi, Khan, Aly Azeem, Yang, Bi-Huei, Fu, Wenxian, Lu, Li-Fan

“…miR-23∼27∼24 was recently implicated in restricting Th2 immunity, as well as the differentiation and function of other effector T cell lineages. Interestingly,…”
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Antidepressant‐like Effect of Magnolol on BDNF Up‐regulation and Serotonergic System Activity in Unpredictable Chronic Mild Stress Treated Rats by Li, Lu‐Fan, Lu, Jie, Li, Xiu‐Min, Xu, Chang‐Liang, Deng, Ji‐Min, Qu, Rong, Ma, Shi‐Ping

“…Magnolol is the main constituent identified in the barks of Magnolia officinalis, which has been used for the treatment of mental disorders including…”
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Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival by Sorrentino, Carlo, Yin, Zhinan, Ciummo, Stefania, Lanuti, Paola, Lu, Li-Fan, Marchisio, Marco, Bellone, Matteo, Di Carlo, Emma

“…Interleukin(IL)-30/IL-27p28 production by Prostate Cancer (PC) Stem-Like Cells (SLCs) has proven, in murine models, to be critical to tumor onset and…”
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