Search Results - "Lu, Kurt. Q."
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Topical application of synthetic melanin promotes tissue repair
Published in npj Regenerative medicine (02-11-2023)“…In acute skin injury, healing is impaired by the excessive release of reactive oxygen species (ROS). Melanin, an efficient scavenger of radical species in the…”
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Early indicators of survival following exposure to mustard gas: Protective role of 25(OH)D
Published in Toxicology letters (25-04-2016)“…•Skin wound area expansion and weight drop are predictors of death from sulfur mustard exposure and may have translational potential as non-invasive…”
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Skin Infiltrate Composition as a Telling Measure of Responses to Checkpoint Inhibitors
Published in JID innovations (01-09-2023)“…Checkpoint inhibitors treat a variety of tumor types with significant benefits. Unfortunately, these therapies come with diverse adverse events. Skin rash is…”
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Vitamin D3 and deconvoluting a rash
Published in JCI insight (24-01-2023)“…BACKGROUNDAdverse drug reactions are unpredictable immunologic events presenting frequent challenges to clinical management. Systemically administered…”
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Single high dose vitamin D3: a promising sunburn therapy
Published in British journal of dermatology (1951) (13-09-2024)Get full text
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Vitamin D improves sunburns by increasing autophagy in M2 macrophages
Published in Autophagy (04-05-2019)“…Cutaneous inflammation from UV radiation exposure causes epidermal damage, cellular infiltration, and secretion of pro-inflammatory mediators that exacerbate…”
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Krüppel-like factor 4 regulates macrophage polarization
Published in The Journal of clinical investigation (01-07-2011)“…Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and…”
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Vitamin D3 and its Potential to Ameliorate Chemical and Radiation-Induced Skin Injury During Cancer Therapy
Published in Disaster medicine and public health preparedness (15-01-2024)“…Skin injury and dermatitis are common complications following chemotherapy and radiation administration for cancer treatment. Symptomatic relief of these…”
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Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study
Published in Journal of investigative dermatology (01-10-2017)“…The diverse immunomodulatory effects of vitamin D are increasingly being recognized. However, the ability of oral vitamin D to modulate acute inflammation…”
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Assessing unmet needs in patients with hidradenitis suppurativa
Published in Archives of Dermatological Research (01-11-2023)“…The diagnosis and management of hidradenitis suppurativa (HS) varies greatly between providers, often resulting in gaps in care including diagnostic delays and…”
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High-Dose Vitamin D for the Management of Toxic Erythema of Chemotherapy in Hospitalized Patients
Published in JAMA dermatology (Chicago, Ill.) (01-02-2023)Get more information
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A novel treatment for skin repair using a combination of spironolactone and vitamin D3
Published in Annals of the New York Academy of Sciences (01-11-2020)“…Injury of the skin from exposure to toxic chemicals leads to the release of inflammatory mediators and the recruitment of immune cells. Nitrogen mustard (NM)…”
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Skin Tape Strip Proteomics in Mycosis Fungoides Identifies Tumor-Associated Biomarkers
Published in Journal of investigative dermatology (01-03-2023)Get full text
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Profibrotic Subsets of SPP1 + Macrophages and POSTN + Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis
Published in Journal of investigative dermatology (01-07-2024)“…Acne keloidalis is a primary scarring alopecia characterized by longstanding inflammation in the scalp causing keloid-like scar formation and hair loss…”
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High-dose vitamin D for the management acute radiation dermatitis
Published in JAAD Case Reports (01-09-2023)Get full text
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Suppression of Hyperactive Immune Responses Protects against Nitrogen Mustard Injury
Published in Journal of investigative dermatology (01-12-2015)“…DNA alkylating agents like nitrogen mustard (NM) are easily absorbed through the skin and exposure to such agents manifest not only in direct cellular death…”
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The Virtues of Oxygenation: Low Tissue Oxygen Adversely Affects the Killing of Leishmania
Published in Journal of investigative dermatology (01-09-2014)“…Hypoxia contributes to the persistence of infections through altered immune responses. Studies examining skin O2 changes at the site of a lesion are limited…”
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Synthetic high-density lipoprotein nanoparticles: Good things in small packages
Published in The ocular surface (01-07-2021)“…Medicine has been a great beneficiary of the nanotechnology revolution. Nanotechnology involves the synthesis of functional materials with at least one size…”
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