Search Results - "Lu, K. P."
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Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation
Published in Nature (London) (16-04-2015)“…Parasites of the Theileria genus infect cattle and transform their host cells, a transformation that can be reversed by treatment with the drug buparvaquone;…”
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2
Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4
Published in Oncogene (07-09-2017)“…BRD4 has emerged as an important factor in tumorigenesis by promoting the transcription of genes involved in cancer development. However, how BRD4 is regulated…”
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The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections
Published in Current molecular medicine (01-11-2016)“…Infection is the process of pathogen invasion, as well as the host reaction to the foreign agents. Proline-directed phosphorylation is a major regulatory…”
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4
Distinct functions of cis and trans phosphorylated tau in Alzheimer's disease and their therapeutic implications
Published in Current molecular medicine (01-08-2013)“…Proline-directed protein phosphorylation (pSer/Thr-Pro), a central signaling mechanism in diverse cellular processes in physiology and disease, has been…”
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The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins
Published in Genes & development (01-03-1998)“…Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs has been shown to play an important role in regulating mitotic progression. Pin1 is a novel…”
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Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism
Published in Cellular and molecular life sciences : CMLS (30-11-1999)“…Protein phosphorylation on serine or threonine residues preceding proline (Ser/Thr-Pro) plays an essential role for regulating various cellular processes,…”
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A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1
Published in Molecular and Cellular Biology (01-11-1996)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A human peptidyl-prolyl isomerase essential for regulation of mitosis
Published in Nature (London) (11-04-1996)“…The NIMA kinase is essential for progression through mitosis in Aspergillus nidulans, and there is evidence for a similar pathway in other eukaryotic cells…”
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FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling
Published in Oncogene (08-11-2012)“…Human basal-like breast cancer (BLBC) is an enigmatic and aggressive malignancy with a poor prognosis. There is an urgent need to identify therapeutic targets…”
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10
Hardness of irradiated hydroxyethyl methacrylate copolymer at elevated temperatures
Published in Journal of applied polymer science (05-07-2009)“…The hardness of irradiated hydroxyethyl methacrylate (HEMA) copolymer at elevated temperatures was measured using a microhardness tester. The hardness…”
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11
Inverse association between cancer and Alzheimer’s disease: results from the Framingham Heart Study
Published in BMJ (12-03-2012)“…Objectives To relate cancer since entry into the Framingham Heart Study with the risk of incident Alzheimer’s disease and to estimate the risk of incident…”
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12
Crystallization and preliminary X-ray diffraction analysis of spermidine synthase from Helicobacter pylori
Published in Acta crystallographica. Section D, Biological crystallography. (01-11-2004)“…Polyamines, such as putrescine, spermidine and spermine, are essential for the regulation of cell proliferation and differentiation in most organisms…”
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13
Pinning down cell signaling, cancer and Alzheimer's disease
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01-04-2004)“…Protein phosphorylation on certain serine or threonine residues preceding proline (Ser/Thr-Pro) is a pivitol signaling mechanism in diverse cellular processes…”
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14
Genomic profiles and predictive biological networks in oxidant-induced atherogenesis
Published in Physiological genomics (13-05-2003)“…1 Center for Environmental and Rural Health, Texas A&M University, College Station, Texas 77843 2 Department of Statistics, Texas A&M University, College…”
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Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA
Published in Molecular cell (01-12-2003)“…The transcription factor NF-κB is activated by the degradation of its inhibitor IκBα, resulting in its nuclear translocation. However, the mechanism by which…”
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Novel genomic targets in oxidant-induced vascular injury
Published in Journal of molecular and cellular cardiology (01-06-2005)“…To study the complex interaction between oxidative injury and the pathogenesis of vascular disease, vascular gene expression was examined in male…”
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The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase Inhibitor
Published in Cell (02-11-2001)“…Telomerase activity is critical for normal and transformed human cells to escape from crisis and is implicated in oncogenesis. Here we describe a novel…”
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Differential expression of ribosomal L31, Zis, gas-5 and mitochondrial mRNAs following oxidant induction of proliferative vascular smooth muscle cell phenotypes
Published in Atherosclerosis (01-02-2002)“…Treatment of cultured vascular smooth muscle cells (vSMCs) with benzo(a)pyrene (BaP), a prooxidant present in the particulate phase of tobacco smoke, induces…”
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19
Density gradients and the expansion–shrinkage transition during sintering
Published in Acta materialia (01-04-2004)“…Links between density gradients, internal microstructure and in situ sintering shrinkage in compacts formed from spray-dried alumina powder are established…”
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Identification of Genes Differentially Expressed in Vascular Smooth Muscle Cells following Benzo[A]Pyrene Challenge: Implications for Chemical Atherogenesis
Published in Biochemical and biophysical research communications (30-12-1998)“…We have previously shown that serial passage of vascular smooth muscle cells (vSMCs) treated with a single low dose of benzo[a]pyrene (BaP) induces acquisition…”
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