Search Results - "Lu, Jenny Ying Lin"

G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium by Yang, Yuhua, Lu, Jenny Ying-Lin, Wu, Xiaosu, Summer, Shamin, Whoriskey, John, Saris, Christiaan, Reagan, Jeff D

“…We report that the asthma drugs cromolyn disodium and nedocromil sodium are potent G-protein-coupled receptor 35 (GPR35) agonists. We utilized calcium flux and…”
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AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents by Lin, Daniel C-H, Zhang, Jane, Zhuang, Run, Li, Frank, Nguyen, Kathy, Chen, Michael, Tran, Thanhvien, Lopez, Edwin, Lu, Jenny Ying Lin, Li, Xiaoyan Nina, Tang, Liang, Tonn, George R, Swaminath, Gayathri, Reagan, Jeff D, Chen, Jin-Long, Tian, Hui, Lin, Yi-Jyun, Houze, Jonathan B, Luo, Jian

“…Agonists of GPR40 (FFA1) have been proposed as a means to treat type 2 diabetes. Through lead optimization of a high throughput screening hit, we have…”
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The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist by Tang, Hua, Lu, Jenny Ying-Lin, Zheng, Xiaomu, Yang, Yuhua, Reagan, Jeff D.

“…Nicotinic acid has been used for several decades to treat dyslipidemia. In mice, the lipid-lowing effect of nicotinic acid is mediated by the Gi coupled…”
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Discovery and Optimization of Substituted 1-(1-Phenyl-1H-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics by Poon, Steve F, St. Jean, David J, Harrington, Paul E, Henley, Charles, Davis, James, Morony, Sean, Lott, Fred D, Reagan, Jeff D, Lu, Jenny Ying-Lin, Yang, Yuhua, Fotsch, Christopher

“…Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development…”
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Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor by Lu, Jenny Ying Lin, Yang, Yuhua, Gnacadja, Gilles, Christopoulos, Arthur, Reagan, Jeff D

“…Over 257 mutations in the human calcium-sensing receptor (hCaSR) gene have been reported. Heterozygous inactivating mutations can result in familial…”
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AMG 837: A potent, orally bioavailable GPR40 agonist by Houze, Jonathan B., Zhu, Liusheng, Sun, Ying, Akerman, Michelle, Qiu, Wei, Zhang, Alex J., Sharma, Rajiv, Schmitt, Michael, Wang, Yingcai, Liu, Jiwen, Liu, Jinqian, Medina, Julio C., Reagan, Jeff D., Luo, Jian, Tonn, George, Zhang, Jane, Lu, Jenny Ying-Lin, Chen, Michael, Lopez, Edwin, Nguyen, Kathy, Yang, Li, Tang, Liang, Tian, Hui, Shuttleworth, Steven J., Lin, Daniel C.-H.

“…The discovery that certain long chain fatty acids potentiate glucose stimulated insulin secretion through the previously orphan receptor GPR40 sparked interest…”
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Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism by Wehn, Paul M., Harrington, Paul E., Carlson, Timothy J., Davis, James, Deprez, Pierre, Fotsch, Christopher H., Grillo, Mark P., Lu, Jenny Ying-Lin, Morony, Sean, Pattabiraman, Kanaka, Poon, Steve F., Reagan, Jeff D., St. Jean, David J., Temal, Taoues, Wang, Minghan, Yang, Yuhua, Henley, Charles, Lively, Sarah E.

“…A series of urea based calcimimetics was optimized for potency and oral bioavailability. Crucial to this process was overcoming the poor pharmacokinetic…”
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The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core by Harrington, Paul E., St. Jean, David J., Clarine, Jeffrey, Coulter, Thomas S., Croghan, Michael, Davenport, Adam, Davis, James, Ghiron, Chiara, Hutchinson, Jonathan, Kelly, Michael G., Lott, Fred, Lu, Jenny Ying-Lin, Martin, David, Morony, Sean, Poon, Steve F., Portero-Larragueta, Elena, Reagan, Jeff D., Regal, Kelly A., Tasker, Andrew, Wang, Minghan, Yang, Yuhua, Yao, Guomin, Zeng, Qingping, Henley, Charles, Fotsch, Christopher

“…Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model. The discovery of a series of novel and orally…”
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Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion by Henley, 3rd, Charles, Yang, Yuhua, Davis, James, Lu, Jenny Ying Lin, Morony, Sean, Fan, Wei, Florio, Monica, Sun, Banghua, Shatzen, Edward, Pretorius, James K, Richards, William G, St Jean, Jr, David J, Fotsch, Christopher, Reagan, Jeff D

“…Calcimimetics are positive allosteric modulators to the calcium-sensing receptor (CaSR). Activation of the CaSR inhibits the secretion of parathyroid hormone…”
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