Search Results - "Lu, J. Yuyang"

Cis- and trans-acting lncRNAs in pluripotency and reprogramming by Yan, Pixi, Luo, Sai, Lu, J Yuyang, Shen, Xiaohua

“…•Cis- and trans-acting lncRNAs are involved in stem cell pluripotency and reprogramming.•lncRNA-mediated cis regulation of nearby transcription is a prevalent…”
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Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells by Luo, Sai, Lu, J. Yuyang, Liu, Lichao, Yin, Yafei, Chen, Chunyan, Han, Xue, Wu, Bohou, Xu, Ronggang, Liu, Wei, Yan, Pixi, Shao, Wen, Lu, Zhi, Li, Haitao, Na, Jie, Tang, Fuchou, Wang, Jianlong, Zhang, Yong E., Shen, Xiaohua

“…Divergent lncRNAs that are transcribed in the opposite direction to nearby protein-coding genes comprise a significant proportion (∼20%) of total lncRNAs in…”
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Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome by Lu, J. Yuyang, Chang, Lei, Li, Tong, Wang, Ting, Yin, Yafei, Zhan, Ge, Han, Xue, Zhang, Ke, Tao, Yibing, Percharde, Michelle, Wang, Liang, Peng, Qi, Yan, Pixi, Zhang, Hui, Bi, Xianju, Shao, Wen, Hong, Yantao, Wu, Zhongyang, Ma, Runze, Wang, Peizhe, Li, Wenzhi, Zhang, Jing, Chang, Zai, Hou, Yingping, Zhu, Bing, Ramalho-Santos, Miguel, Li, Pilong, Xie, Wei, Na, Jie, Sun, Yujie, Shen, Xiaohua

“…Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation. In…”
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Phase separation of RNA-binding protein promotes polymerase binding and transcription by Shao, Wen, Bi, Xianju, Pan, Yixuan, Gao, Boyang, Wu, Jun, Yin, Yafei, Liu, Zhimin, Peng, Mengyuan, Zhang, Wenhao, Jiang, Xu, Ren, Wenlin, Xu, Yanhui, Wu, Zhongyang, Wang, Kaili, Zhan, Ge, Lu, J. Yuyang, Han, Xue, Li, Tong, Wang, Jianlong, Li, Guohong, Deng, Haiteng, Li, Bing, Shen, Xiaohua

“…An RNA-involved phase-separation model has been proposed for transcription control. However, the molecular links that connect RNA to the transcription…”
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Long-lived fish in a big pond by Lu, J Yuyang, Seluanov, Andrei, Gorbunova, Vera

“…The genetic drivers of extreme longevity in Pacific Ocean rockfish are identified…”
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Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice by Zhang, Zhihui, Tian, Xiao, Lu, J. Yuyang, Boit, Kathryn, Ablaeva, Julia, Zakusilo, Frances Tolibzoda, Emmrich, Stephan, Firsanov, Denis, Rydkina, Elena, Biashad, Seyed Ali, Lu, Quan, Tyshkovskiy, Alexander, Gladyshev, Vadim N., Horvath, Steve, Seluanov, Andrei, Gorbunova, Vera

“…Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance and possibly to the longevity of the longest-lived rodent—the naked…”
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Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation by Lu, J. Yuyang, Shao, Wen, Chang, Lei, Yin, Yafei, Li, Tong, Zhang, Hui, Hong, Yantao, Percharde, Michelle, Guo, Lerui, Wu, Zhongyang, Liu, Lichao, Liu, Wei, Yan, Pixi, Ramalho-Santos, Miguel, Sun, Yujie, Shen, Xiaohua

“…Repetitive elements are abundantly distributed in mammalian genomes. Here, we reveal a striking association between repeat subtypes and gene function. SINE,…”
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RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control by Bi, Xianju, Xu, Yanhui, Li, Tong, Li, Xinmin, Li, Wenzhi, Shao, Wen, Wang, Kaili, Zhan, Ge, Wu, Zhongyang, Liu, Wei, Lu, J. Yuyang, Wang, Liang, Zhao, Jicheng, Wu, Jiawei, Na, Jie, Li, Guohong, Li, Pilong, Shen, Xiaohua

“…Transcription regulation underlies stem cell function and development. Here, we elucidate an unexpected role of an essential ribogenesis factor, WDR43, as…”
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Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle by Zhao, Yang, Zheng, Zhizhong, Zhang, Zhihui, Xu, Yandong, Hillpot, Eric, Lin, Yifei S., Zakusilo, Frances T., Lu, J. Yuyang, Ablaeva, Julia, Biashad, Seyed Ali, Miller, Richard A., Nevo, Eviatar, Seluanov, Andrei, Gorbunova, Vera

“…Hyaluronic acid is a major component of extracellular matrix which plays an important role in development, cellular response to injury and inflammation, cell…”
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DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation by Zhang, Hui, Wu, Zhongyang, Lu, J. Yuyang, Huang, Bo, Zhou, Hongwei, Xie, Wei, Wang, Jianlong, Shen, Xiaohua

“…Embryonic stem cells (ESCs) exhibit high levels of ribosomal RNA (rRNA) transcription and ribosome biogenesis. Here, we reveal an unexpected role for an…”
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Insight into novel RNA-binding activities via large-scale analysis of lncRNA-bound proteome and IDH1-bound transcriptome by Liu, Lichao, Li, Tong, Song, Guang, He, Qingxia, Yin, Yafei, Lu, J Yuyang, Bi, Xianju, Wang, Kaili, Luo, Sai, Chen, Yu-Sheng, Yang, Ying, Sun, Bao-Fa, Yang, Yun-Gui, Wu, Jiawei, Zhu, Heng, Shen, Xiaohua

“…Abstract RNA-binding proteins (RBPs) play pivotal roles in directing RNA fate and function. Yet the current annotation of RBPs is largely limited to proteins…”
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Transposon-triggered innate immune response confers cancer resistance to the blind mole rat by Zhao, Yang, Oreskovic, Ena, Zhang, Quanwei, Lu, Quan, Gilman, Abbey, Lin, Yifei S., He, Junyue, Zheng, Zhizhong, Lu, J. Yuyang, Lee, Jina, Ke, Zhonghe, Ablaeva, Julia, Sweet, Matthew J., Horvath, Steve, Zhang, Zhengdong, Nevo, Eviatar, Seluanov, Andrei, Gorbunova, Vera

“…Blind mole rats (BMRs) are small rodents, characterized by an exceptionally long lifespan (>21 years) and resistance to both spontaneous and induced…”
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U1 snRNP regulates chromatin retention of noncoding RNAs by Yin, Yafei, Lu, J. Yuyang, Zhang, Xuechun, Shao, Wen, Xu, Yanhui, Li, Pan, Hong, Yantao, Cui, Li, Shan, Ge, Tian, Bin, Zhang, Qiangfeng Cliff, Shen, Xiaohua

“…Long noncoding RNAs (lncRNAs) and promoter- or enhancer-associated unstable transcripts locate preferentially to chromatin, where some regulate chromatin…”
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Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development by Han, Xue, Luo, Sai, Peng, Guangdun, Lu, J Yuyang, Cui, Guizhong, Liu, Lichao, Yan, Pixi, Yin, Yafei, Liu, Wei, Wang, Ran, Zhang, Jiejie, Ai, Shanshan, Chang, Zai, Na, Jie, He, Aibin, Jing, Naihe, Shen, Xiaohua

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Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation by Lu, J. Yuyang, Simon, Matthew, Zhao, Yang, Ablaeva, Julia, Corson, Nancy, Choi, Yongwook, Yamada, KayLene Y.H., Schork, Nicholas J., Hood, Wendy R., Hill, Geoffrey E., Miller, Richard A., Seluanov, Andrei, Gorbunova, Vera

“…Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified…”
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LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency by Yan, Pixi, Lu, J Yuyang, Niu, Jing, Gao, Juntao, Zhang, Michael Q, Yin, Yafei, Shen, Xiaohua

“…Super-enhancers (SEs) comprise large clusters of enhancers, which are co-occupied by multiple lineage-specific and master transcription factors, and play…”
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IDH1 fine-tunes cap-dependent translation initiation by Liu, Lichao, Lu, J Yuyang, Li, Fajin, Xing, Xudong, Li, Tong, Yang, Xuerui, Shen, Xiaohua

“…The metabolic enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). Its mutation often…”
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