Search Results - "Lu, Hongzhong"

A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism by Lu, Hongzhong, Li, Feiran, Sánchez, Benjamín J., Zhu, Zhengming, Li, Gang, Domenzain, Iván, Marcišauskas, Simonas, Anton, Petre Mihail, Lappa, Dimitra, Lieven, Christian, Beber, Moritz Emanuel, Sonnenschein, Nikolaus, Kerkhoven, Eduard J., Nielsen, Jens

“…Genome-scale metabolic models (GEMs) represent extensive knowledgebases that provide a platform for model simulations and integrative analysis of omics data…”
Get full text

Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces by Wang, Weishan, Li, Shanshan, Li, Zilong, Zhang, Jingyu, Fan, Keqiang, Tan, Gaoyi, Ai, Guomin, Lam, Sin Man, Shui, Guanghou, Yang, Zhiheng, Lu, Hongzhong, Jin, Pinjiao, Li, Yihong, Chen, Xiangyin, Xia, Xuekui, Liu, Xueting, Dannelly, H. Kathleen, Yang, Chen, Yang, Yi, Zhang, Siliang, Alterovitz, Gil, Xiang, Wensheng, Zhang, Lixin

“…Pharmaceutically important polyketides such as avermectin are mainly produced as secondary metabolites during the stationary phase of growth of Streptomyces…”
Get full text

Experimental Study on PIV Measurement and CFD Investigation of the Internal Flow Characteristics in a Reactor Coolant Pump by Ni, Dan, Lu, Hongzhong, Huang, Shiyuan, Lu, Sheng, Zhang, Yang

“…The nuclear reactor coolant pump (RCP) is the core piece of equipment of a nuclear power plant (NPP). The energy performance and internal flow characteristics…”
Get full text

Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection by Lu, Hongzhong, Li, Feiran, Yuan, Le, Domenzain, Iván, Yu, Rosemary, Wang, Hao, Li, Gang, Chen, Yu, Ji, Boyang, Kerkhoven, Eduard J, Nielsen, Jens

“…Yeasts are known to have versatile metabolic traits, while how these metabolic traits have evolved has not been elucidated systematically. We performed…”
Get full text

Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition by Lu, Hongzhong, Cao, Weiqiang, Liu, Xiaoyun, Sui, Yufei, Ouyang, Liming, Xia, Jianye, Huang, Mingzhi, Zhuang, Yingping, Zhang, Siliang, Noorman, Henk, Chu, Ju

“…Oxygen limitation is regarded as a useful strategy to improve enzyme production by mycelial fungus like Aspergillus niger . However, the intracellular…”
Get full text

Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation by Cao, Weiqiang, Wang, Guan, Lu, Hongzhong, Ouyang, Liming, Chu, Ju, Sui, Yufei, Zhuang, Yingping

“…Glucoamylase is one of the most industrially applied enzymes, produced by Aspergillus species, like Aspergillus niger. Compared to the traditional ways of…”
Get full text

Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger by Sui, Yu-fei, Schütze, Tabea, Ouyang, Li-ming, Lu, Hongzhong, Liu, Peng, Xiao, Xianzun, Qi, Jie, Zhuang, Ying-Ping, Meyer, Vera

“…Abstract Background Nicotinamide adenine dinucleotide phosphate (NADPH) is an important cofactor ensuring intracellular redox balance, anabolism and cell…”
Get full text

Yeast9: a consensus genome-scale metabolic model for S. cerevisiae curated by the community by Zhang, Chengyu, Sánchez, Benjamín J, Li, Feiran, Eiden, Cheng Wei Quan, Scott, William T, Liebal, Ulf W, Blank, Lars M, Mengers, Hendrik G, Anton, Mihail, Rangel, Albert Tafur, Mendoza, Sebastián N, Zhang, Lixin, Nielsen, Jens, Lu, Hongzhong, Kerkhoven, Eduard J

“…Genome-scale metabolic models (GEMs) can facilitate metabolism-focused multi-omics integrative analysis. Since Yeast8, the yeast-GEM of Saccharomyces…”
Get full text

A Pan-Draft Metabolic Model Reflects Evolutionary Diversity across 332 Yeast Species by Lu, Hongzhong, Kerkhoven, Eduard J., Nielsen, Jens

“…Yeasts are increasingly employed in synthetic biology as chassis strains, including conventional and non-conventional species. It is still unclear how genomic…”
Get full text

Author Correction: A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism by Lu, Hongzhong, Li, Feiran, Sánchez, Benjamín J., Zhu, Zhengming, Li, Gang, Domenzain, Iván, Marcišauskas, Simonas, Anton, Petre Mihail, Lappa, Dimitra, Lieven, Christian, Beber, Moritz Emanuel, Sonnenschein, Nikolaus, Kerkhoven, Eduard J., Nielsen, Jens

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing by Jiang, Lan, Zhang, Tianji, Lu, Hongzhong, Li, Saijuan, Lv, Kangjie, Tuffour, Alex, Zhang, Lixin, Ding, Kan, Li, Jin-Ping, Li, Hongmei, Liu, Xueting

“…The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy. Moreover, after more than 2 years, many…”
Get full text

Comprehensive reconstruction and evaluation of Pichia pastoris genome-scale metabolic model that accounts for 1243 ORFs by Ye, Rui, Huang, Mingzhi, Lu, Hongzhong, Qian, Jiangchao, Lin, Weilu, Chu, Ju, Zhuang, Yingping, Zhang, Siliang

“…Background Pichia pastoris is one of the most important cell factories for production of industrial enzymes and heterogenous proteins. The genome-scale…”
Get full text

Deep learning-based kcat prediction enables improved enzyme-constrained model reconstruction by Li, Feiran, Yuan, Le, Lu, Hongzhong, Li, Gang, Chen, Yu, Engqvist, Martin K. M., Kerkhoven, Eduard J., Nielsen, Jens

“…Enzyme turnover numbers ( k cat ) are key to understanding cellular metabolism, proteome allocation and physiological diversity, but experimentally measured k…”
Get full text

Multiscale models quantifying yeast physiology: towards a whole-cell model by Lu, Hongzhong, Kerkhoven, Eduard J., Nielsen, Jens

“…The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important eukaryal model organism for studying cellular physiology related to…”
Get full text

Study of driving force characteristics in the formation of dominant unstable flow events in water jet propulsion pumps by Zhao, Haoru, Wang, Fujun, Wang, Chaoyue, Lu, Hongzhong, Zhu, Baoshan

Get full text

Cell factory design with advanced metabolic modelling empowered by artificial intelligence by Lu, Hongzhong, Xiao, Luchi, Liao, Wenbin, Yan, Xuefeng, Nielsen, Jens

“…Advances in synthetic biology and artificial intelligence (AI) have provided new opportunities for modern biotechnology. High-performance cell factories, the…”
Get full text

DeepEnzyme: a robust deep learning model for improved enzyme turnover number prediction by utilizing features of protein 3D-structures by Wang, Tong, Xiang, Guangming, He, Siwei, Su, Liyun, Wang, Yuguang, Yan, Xuefeng, Lu, Hongzhong

“…Abstract Turnover numbers (kcat), which indicate an enzyme's catalytic efficiency, have a wide range of applications in fields including protein engineering…”
Get full text

A new composite modelling strategy for engineering computation of turbulence modulation in dilute solid-liquid two-phase flows by Chen, Wenhao, Wang, Fujun, He, Chunxun, Tang, Xuelin, Lu, Hongzhong, Wang, Chaoyue

“…Turbulence modulation is an important physical phenomenon in solid-liquid two-phase flows, including two co-effects of wake enhancement and resistance…”
Get full text

Comprehensive reconstruction and in silico analysis of Aspergillus niger genome‐scale metabolic network model that accounts for 1210 ORFs by Lu, Hongzhong, Cao, Weiqiang, Ouyang, Liming, Xia, Jianye, Huang, Mingzhi, Chu, Ju, Zhuang, Yingping, Zhang, Siliang, Noorman, Henk

“…ABSTRACT Aspergillus niger is one of the most important cell factories for industrial enzymes and organic acids production. A comprehensive genome‐scale…”
Get full text

Exploring the mechanism of improving the pressure fluctuation of double suction centrifugal pump by impeller stagger by Liu, Qiang, Lu, Zhaoheng, Tao, Ran, Lu, Hongzhong, Xiao, Ruofu

“…Background The pressure fluctuation in the volute can be effectively reduced when the impeller of the double-suction pump is staggered, but the mechanism of…”
Get full text