Search Results - "Lu, Hongfu"

Interface defect chemistry enables dendrite-free lithium metal anodes by Mu, Tiansheng, Lu, Hongfu, Ren, Yang, Wan, Xin, Xu, Xing, Tan, Siping, Ma, Yulin, Yin, Geping

“…•An artificial protective layer with interface defects is proposed;•Interface defect chemistry promotes the lithium ions diffusion kinetics;•Interface oxygen…”
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Mild and Regioselective N‑Alkylation of 2‑Pyridones in Water by Hao, Xin, Xu, Zhongmiao, Lu, Hongfu, Dai, Xuedong, Yang, Ting, Lin, Xichen, Ren, Feng

“…A mild and regioselective N-alkylation reaction of 2-pyridones in water has been developed. Tween 20 (2% w/w) was added to create a micellar system for…”
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Efficient and C2-selective arylation of indoles, benzofurans, and benzothiophenes with iodobenzenes in water at room temperature by Xu, Zhongmiao, Xu, Yulong, Lu, Hongfu, Yang, Ting, Lin, Xichen, Shao, Liming, Ren, Feng

“…A mild, efficient, and C2-selective palladium-catalyzed arylation reaction of indoles, benzofurans, and benzothiophenes with iodobenzenes at room temperature…”
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Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors by Peng, Jingjing, Ding, Xiaoyu, Shih, Pei-Yu, Meng, Qingyuan, Ding, Xiao, Zhang, Man, Aliper, Alex, Ren, Feng, Lu, Hongfu, Zhavoronkov, Alex

“…Although immune checkpoint inhibitors (ICIs) have been a revelation for treating several cancers, an unmet need remains to broaden ICI therapeutic scope and…”
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Constructing an inorganic/organic mixed protective film for low-cost fabrication of stable lithium metal anode by Liu, Yaxin, Liu, Songsong, Tan, Siping, Jiang, Zhenfei, Hu, Xinyu, Lu, Hongfu, Yin, Geping, Gao, Yunzhi, Ma, Yulin

“…Lithium metal has been recognized as the most promising anode for next generation of ultra-high energy density batteries. However, lithium dendrites have…”
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Discovery of a Novel Macrocyclic Noncovalent CDK7 Inhibitor for Cancer Therapy by Lu, Hongfu, Zhang, Yihong, Liu, Jinxin, Jiang, Tao, Yu, Xiang, Zhang, Haoyu, Liang, Tao, Peng, Jingjing, Cai, Xin, Lan, Xiaoling, Ren, Jinmin, Ge, Mei, Zhang, Jingyang, Shang, Jingjin, Yu, Jiaojiao, Ren, Hongcan, Liu, Qiang, Gao, Jinting, Tang, Lili, Ding, Xiao, Zhang, Man, Aliper, Alex, Lu, Qiang, Zhou, Fusheng, Lan, Jiong, Ren, Feng, Zhavoronkov, Alex

“…Cyclin-dependent kinase 7 (CDK7) is a key regulator of the cell cycle and transcription, making it a promising target for cancer therapy. Although current CDK7…”
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Design, Synthesis, and Biological Evaluation of a Series of Spiro Analogues as Novel HPK1 Inhibitors by Peng, Jingjing, Ding, Xiaoyu, Chen, Celia X. J., Shih, Pei-Yu, Meng, Qingyuan, Ding, Xiao, Zhang, Man, Aliper, Alex, Ren, Feng, Lu, Hongfu, Zhavoronkov, Alex

“…Hematopoietic progenitor kinase 1 (HPK1) negatively affects T cell activation and proliferation and is a promising target for immunotherapy. Although HPK1…”
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Chiral 2-aminopyrimidin-4(1H)-one derivative as the novel bifunctional organocatalyst: enantioselective Aldol reaction of isatins with ketones by Lu, Hongfu, Bai, Jingtao, Xu, Jianyu, Yang, Ting, Lin, Xichen, Li, Jian, Ren, Feng

“…Chiral 2-aminopyrimidin-4(1H)-one derivative 2 was discovered as a novel bifunctional organocatalyst for the asymmetric Aldol reaction of isatins with ketones…”
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Abstract 1855: Targeting DGKA for immuno-oncology therapy: ISM4312A, a novel DGKA inhibitor with robust anti-tumor activity by Sun, Deheng, Lu, Hongfu, Yu, Huaxing, Wang, Feng, Korzinkin, Mike, Cai, Xin, Ding, Xiao, Rao, Sujata, Ren, Feng, Zhavoronkov, Alex

“…Abstract Diacylglycerol kinases (DGKs), a family of isozymes that phosphorylate the membrane lipid, diacylglycerol (DAG), to phosphatidic acid (PA), are…”
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Abstract 3967: ISM9182A, a novel HPK1 inhibitor, exhibits immune modulatory activity and robust monotherapy anti-tumor effects in preclinical studies by Chen, Celia X.-J., Pu, Congying, Peng, Jingjing, Ding, Xiaoyu, Lu, Hongfu, Ding, Xiao, Zhang, Man, Bavadekar, Supriya, Rao, Sujata, Ren, Feng, Zhavoronkov, Alex

“…Abstract The hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a member of the Ste20 serine/threonine kinase super family that negatively regulates immune…”
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Discovery of Novel 1‑Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists by Lu, Hongfu, Yang, Ting, Xu, Zhongmiao, Lin, Xichen, Ding, Qian, Zhang, Yueting, Cai, Xin, Dong, Kelly, Gong, Sophie, Zhang, Wei, Patel, Metul, Copley, Royston C. B, Xiang, Jianing, Guan, Xiaoming, Wren, Paul, Ren, Feng

“…CXCR2 has emerged as a therapeutic target for not only peripheral inflammatory diseases but also neurological abnormalities in the central nervous system…”
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Abstract 4989: Discovery and evaluation of ISM6466A, a novel covalent CDK12 inhibitor for the treatment of cancer by Min, Lihua, Lu, Hongfu, Zhang, Yihong, Wu, Jianping, Cai, Xin, Zheng, Min, Cui, Hui, Qiao, Junwen, Ding, Xiao, Rao, Sujata, Ren, Feng, Zhavoronkov, Alex

“…Abstract Cyclin-dependent kinase 12 (CDK12) belongs to the cyclin-dependent kinase (CDK) family of serine/threonine protein kinases. The CDK12/cyclin K complex…”
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2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists by Lu, Hongfu, Yang, Ting, Xu, Zhongmiao, Wren, Paul B., Zhang, Yueting, Cai, Xin, Patel, Metul, Dong, Kelly, Zhang, Qing, Zhang, Wei, Guan, Xiaoming, Xiang, Jianing, Elliott, John D., Lin, Xichen, Ren, Feng

“…[Display omitted] 2-Aminopyrimidin-4(1H)-one was proposed as the novel bioisostere of urea. Bioisosteric replacement of the reported urea series of the CXCR2…”
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Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders by Xu, Heng, Lu, Hongfu, Xu, Zhongmiao, Luan, Linbo, Li, Chengyong, Xu, Yan, Dong, Kelly, Zhang, Jinqiang, Li, Xiong, Li, Yvonne, Liu, Gentao, Gong, Sophie, Zhao, Yong-Gang, Liu, Ailian, Zhang, Yueting, Zhang, Wei, Cai, Xin, Xiang, Jia-Ning, Elliott, John D, Lin, Xichen

“…Structure–activity relationship exploration of the historical biarylurea series led to the identification of novel CNS penetrant CXCR2 antagonists with…”
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