Search Results - "Lu, Chris X."

TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis by Zhang, Long, Zhou, Fangfang, García de Vinuesa, Amaya, de Kruijf, Esther M., Mesker, Wilma E., Hui, Li, Drabsch, Yvette, Li, Yihao, Bauer, Andreas, Rousseau, Adrien, Sheppard, Kelly-Ann, Mickanin, Craig, Kuppen, Peter J.K., Lu, Chris X., ten Dijke, Peter

“…TGF-β signaling is a therapeutic target in advanced cancers. We identified tumor necrosis factor receptor-associated factor 4 (TRAF4) as a key component…”
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USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor by Zhang, Long, Zhou, FangFang, Drabsch, Yvette, Gao, Rui, Snaar-Jagalska, B. Ewa, Mickanin, Craig, Huang, Huizhe, Sheppard, Kelly-Ann, Porter, Jeff A., Lu, Chris X., ten Dijke, Peter

“…The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is…”
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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation by Qi, Wei, Chan, HoMan, Tenga, Lin, Li, Ling, Chuai, Shannon, Zhang, Ruipeng, Zeng, Jue, Li, Min, Fan, Hong, Lin, Ying, Gu, Justin, Ardayfio, Ophelia, Zhang, Ji-Hu, Yan, Xiaoxia, Fang, Jialuo, Mi, Yuan, Zhang, Man, Zhou, Tao, Feng, Grace, Chen, Zijun, Li, Guobin, Yang, Teddy, Zhao, Kehao, Liu, Xianghui, Yu, Zhengtian, Lu, Chris X., Atadja, Peter, Li, En

“…Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by…”
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Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function by Leupin, Olivier, Piters, Elke, Halleux, Christine, Hu, Shouih, Kramer, Ina, Morvan, Frederic, Bouwmeester, Tewis, Schirle, Markus, Bueno-Lozano, Manuel, Ramos Fuentes, Feliciano J., Itin, Peter H., Boudin, Eveline, de Freitas, Fenna, Jennes, Karen, Brannetti, Barbara, Charara, Nadine, Ebersbach, Hilmar, Geisse, Sabine, Lu, Chris X., Bauer, Andreas, Van Hul, Wim, Kneissel, Michaela

“…Humans lacking sclerostin display progressive bone overgrowth due to increased bone formation. Although it is well established that sclerostin is an…”
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RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation by Zhang, Long, Huang, Huizhe, Zhou, FangFang, Schimmel, Joost, Pardo, Cristina Gontan, Zhang, Tingting, Barakat, Tahsin Stefan, Sheppard, Kelly-Ann, Mickanin, Craig, Porter, Jeff A., Vertegaal, Alfred C.O., van Dam, Hans, Gribnau, Joost, Lu, Chris X., ten Dijke, Peter

“…TGF-β members are of key importance during embryogenesis and tissue homeostasis. Smad7 is a potent antagonist of TGF-β family/Smad-mediated responses, but the…”
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Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer by Dong, Xiaoxi, Zheng, Tiantian, Zhang, Minhua, Dai, Chao, Wang, Lili, Wang, Lei, Zhang, Ruipeng, Long, Yuan, Wen, Danyi, Xie, Feng, Zhang, Yue, Huang, Yong, Dong, Jianguo, Liu, Huan, Du, Pan, King, Bonnie L., Tan, Winston, Jia, Shidong, Lu, Chris X., Kohli, Manish, Wang, Haitao, Yu, Jianjun

“…Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions…”
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Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6 by Zhang, Xiaofei, Zhang, Juan, Bauer, Andreas, Zhang, Long, Selinger, Douglas W, Lu, Chris X, ten Dijke, Peter

“…SMAD6 is a crucial feedback inhibitory regulator of bone morphogenetic protein (BMP)/SMAD signalling. Although little is known regarding the…”
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An effective AKT inhibitor-PARP inhibitor combination therapy for recurrent ovarian cancer by Xu, Jing, Gao, Yi, Luan, Xiaotian, Li, Ke, Wang, Jing, Dai, Yilin, Kang, Mingyi, Lu, Chong, Zhang, Minhua, Lu, Chris X., Kang, Yu, Xu, Congjian

“…Background Although the use of PARP inhibitor has received considerable amount of attention in ovarian cancer, PARP inhibitor resistance still emerges with…”
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Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling by Zhou, FangFang, Drabsch, Yvette, Dekker, Tim J. A., de Vinuesa, Amaya Garcia, Li, Yihao, Hawinkels, Lukas J. A. C., Sheppard, Kelly-Ann, Goumans, Marie-José, Luwor, Rodney B., de Vries, Carlie J., Mesker, Wilma E., Tollenaar, Rob A. E. M., Devilee, Peter, Lu, Chris X., Zhu, Hongjian, Zhang, Long, Dijke, Peter ten

“…In advanced cancers, the TGF-β pathway acts as an oncogenic factor and is considered to be a therapeutic target. Here using a genome-wide cDNA screen, we…”
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Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth by Harbinski, Fred, Craig, Vanessa J, Sanghavi, Sneha, Jeffery, Douglas, Liu, Lijuan, Sheppard, Kelly Ann, Wagner, Sabrina, Stamm, Christelle, Buness, Andreas, Chatenay-Rivauday, Christian, Yao, Yao, He, Feng, Lu, Chris X, Guagnano, Vito, Metz, Thomas, Finan, Peter M, Hofmann, Francesco, Sellers, William R, Porter, Jeffrey A, Myer, Vic E, Graus-Porta, Diana, Wilson, Christopher J, Buckler, Alan, Tiedt, Ralph

“…The overall power of kinase inhibitors is substantially overshadowed by the acquisition of drug resistance. To address this issue, we systematically assessed…”
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RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation by Zhang, Long, Huang, Huizhe, Zhou, FangFang, Schimmel, Joost, Pardo, Cristina Gontan, Zhang, Tingting, Barakat, Tahsin Stefan, Sheppard, Kelly-Ann, Mickanin, Craig, Porter, Jeff A., Vertegaal, Alfred C.O., van Dam, Hans, Gribnau, Joost, Lu, Chris X., ten Dijke, Peter

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USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-[beta] type I receptor by Zhang, Long, Zhou, Fangfang, Drabsch, Yvette, Gao, Rui, Snaar-jagalska, B Ewa, Mickanin, Craig, Huang, Huizhe, Sheppard, Kelly-ann, Porter, Jeff A, Lu, Chris X, Ten Dijke, Peter

“…The stability and membrane localization of the transforming growth factor-[beta] (TGF-[beta]) type I receptor (T[beta]RI) determines the levels of TGF-[beta]…”
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Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-[beta] signalling by Zhou, Fangfang, Drabsch, Yvette, Dekker, Tim J A, De Vinuesa, Amaya Garcia, Li, Yihao, Hawinkels, Lukas J A C, Sheppard, Kelly-ann, Goumans, Marie-josé, Luwor, Rodney B, De Vries, Carlie J, Mesker, Wilma E, Tollenaar, Rob A E M, Devilee, Peter, Lu, Chris X, Zhu, Hongjian, Zhang, Long, Dijke, Peter Ten

“…In advanced cancers, the TGF-β pathway acts as an oncogenic factor and is considered to be a therapeutic target. Here using a genome-wide cDNA screen, we…”
Get full text