Search Results - "Lozovsky, Elena R."

Biophysical principles predict fitness landscapes of drug resistance by Rodrigues, João V., Bershtein, Shimon, Li, Anna, Lozovsky, Elena R., Hartl, Daniel L., Shakhnovich, Eugene I.

“…Fitness landscapes of drug resistance constitute powerful tools to elucidate mutational pathways of antibiotic escape. Here, we developed a predictive…”
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Stepwise acquisition of pyrimethamine resistance in the malaria parasite by Lozovsky, Elena R, Chookajorn, Thanat, Brown, Kyle M, Imwong, Mallika, Shaw, Philip J, Kamchonwongpaisan, Sumalee, Neafsey, Daniel E, Weinreich, Daniel M, Hartl, Daniel L

“…The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible…”
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Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum by Bethke, Lara L., Zilversmit, Martine, Nielsen, Kaare, Daily, Johanna, Volkman, Sarah K., Ndiaye, Daouda, Lozovsky, Elena R., Hartl, Daniel L., Wirth, Dyann F.

“…While genes encoding antigens and other highly polymorphic proteins are commonly found in subtelomeres, it is unusual to find a small family of housekeeping…”
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Relevance of Higher-Order Epistasis in Drug Resistance by Lozovsky, Elena R, Daniels, Rachel F, Heffernan, Gavin D, Jacobus, David P, Hartl, Daniel L

“…Abstract We studied five chemically distinct but related 1,3,5-triazine antifolates with regard to their effects on growth of a set of mutants in dihydrofolate…”
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Switching an active site helix in dihydrofolate reductase reveals limits to subdomain modularity by Zhao, Victor Y., Rodrigues, João V., Lozovsky, Elena R., Hartl, Daniel L., Shakhnovich, Eugene I.

“…To what degree are individual structural elements within proteins modular such that similar structures from unrelated proteins can be interchanged? We study…”
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Patterns of insertion and deletion in contrasting chromatin domains by Blumenstiel, Justin P, Hartl, Daniel L, Lozovsky, Elena R

“…Transposable elements (TEs) play a fundamental role in the evolution of genomes. In Drosophila they are disproportionately represented in regions of low…”
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Compensatory mutations restore fitness during the evolution of dihydrofolate reductase by Brown, Kyle M, Costanzo, Marna S, Xu, Wenxin, Roy, Scott, Lozovsky, Elena R, Hartl, Daniel L

“…Whether a trade-off exists between robustness and evolvability is an important issue for protein evolution. Although traditional viewpoints have assumed that…”
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Polytene Chromosomal Maps of 11 Drosophila Species: The Order of Genomic Scaffolds Inferred From Genetic and Physical Maps by Schaeffer, Stephen W, Bhutkar, Arjun, McAllister, Bryant F, Matsuda, Muneo, Matzkin, Luciano M, O'Grady, Patrick M, Rohde, Claudia, Valente, Vera L.S, Aguade, Montserrat, Anderson, Wyatt W, Edwards, Kevin, Garcia, Ana C.L, Goodman, Josh, Hartigan, James, Kataoka, Eiko, Lapoint, Richard T

“…The sequencing of the 12 genomes of members of the genus Drosophila was taken as an opportunity to reevaluate the genetic and physical maps for 11 of the…”
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Accessible Mutational Trajectories for the Evolution of Pyrimethamine Resistance in the Malaria Parasite Plasmodium vivax by Jiang, Pan-Pan, Corbett-Detig, Russell B., Hartl, Daniel L., Lozovsky, Elena R.

“…Antifolate antimalarials, such as pyrimethamine, have experienced a dramatic reduction in therapeutic efficacy as resistance has evolved in multiple malaria…”
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Gene conversion as a source of nucleotide diversity in Plasmodium falciparum by Nielsen, Kaare M, Kasper, Jacob, Choi, Mehee, Bedford, Trevor, Kristiansen, Kurt, Wirth, Dyann F, Volkman, Sarah K, Lozovsky, Elena R, Hartl, Daniel L

“…Examination of polymorphisms in the Plasmodium falciparum gene for falcipain 2 revealed that this gene is one of two paralogs separated by 10.8 kb in…”
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Unexpected Stability of mariner Transgenes in Drosophila by Lozovsky, Elena R, Nurminsky, Dmitry, Wimmer, Ernst A, Hartl, Daniel L

“…A number of mariner transformation vectors based on the mauritiana subfamily of transposable elements were introduced into the genome of Drosophila…”
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