Search Results - "Lozito, Thomas"

Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration by Lozito, Thomas P, Tuan, Rocky S

“…Lizards are amniotes with the remarkable ability to regenerate amputated tails. The early regenerated lizard tail forms a blastema, and the regenerated…”
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Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs by Lozito, Thomas P., Tuan, Rocky S.

“…Mesenchymal stem cells (MSCs) have been shown to be perivascular, occupying a prime location for regulating vessel stability. Here, we focused on the…”
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Lizard tail regeneration as an instructive model of enhanced healing capabilities in an adult amniote by Lozito, Thomas P, Tuan, Rocky S

“…The ability to regenerate damaged or lost tissues has remained the lofty goal of regenerative medicine. Unfortunately, humans, like most mammals, suffer from…”
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Lizard tail regeneration: regulation of two distinct cartilage regions by Indian hedgehog by Lozito, Thomas P., Tuan, Rocky S.

“…Lizards capable of caudal autotomy exhibit the remarkable ability to “drop” and then regenerate their tails. However, the regenerated lizard tail (RLT) is…”
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Introducing dorsoventral patterning in adult regenerating lizard tails with gene-edited embryonic neural stem cells by Lozito, Thomas P., Londono, Ricardo, Sun, Aaron X., Hudnall, Megan L.

“…Lizards regenerate amputated tails but fail to recapitulate the dorsoventral patterning achieved during embryonic development. Regenerated lizard tails form…”
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Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold by Lin, Hang, Tang, Ying, Lozito, Thomas P, Oyster, Nicholas, Wang, Bing, Tuan, Rocky S

“…Stem cell-based bone tissue engineering shows promise for bone repair but faces some challenges, such as insufficient osteogenesis and limited architecture…”
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Stem Cell-Based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1β by Lin, Hang, Lozito, Thomas P, Alexander, Peter G, Gottardi, Riccardo, Tuan, Rocky S

“…Osteoarthritis (OA) is a chronic degenerative disease of the articular joint that involves both bone and cartilage degenerative changes. An engineered…”
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Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders by Sun, Aaron X., Londono, Ricardo, Hudnall, Megan L., Tuan, Rocky S., Lozito, Thomas P.

“…While lizards and salamanders both exhibit the ability to regenerate amputated tails, the outcomes achieved by each are markedly different. Salamanders, such…”
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Human mesenchymal stem cells generate a distinct pericellular zone of MMP activities via binding of MMPs and secretion of high levels of TIMPs by Lozito, Thomas P., Jackson, Wesley M., Nesti, Leon J., Tuan, Rocky S.

“…Mesenchymal stem cells (MSCs) are attractive candidates for inclusion in cell-based therapies by virtue of their abilities to home to wound sites. However,…”
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Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis by Vonk, Ariel C., Zhao, Xiaofan, Pan, Zheyu, Hudnall, Megan L., Oakes, Conrad G., Lopez, Gabriela A., Hasel-Kolossa, Sarah C., Kuncz, Alexander W. C., Sengelmann, Sasha B., Gamble, Darian J., Lozito, Thomas P.

“…Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals capable of epimorphic tail regrowth. However, the mechanisms…”
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Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton by Cui, Cheng, Chatterjee, Bishwanath, Lozito, Thomas P, Zhang, Zhen, Francis, Richard J, Yagi, Hisato, Swanhart, Lisa M, Sanker, Subramaniam, Francis, Deanne, Yu, Qing, San Agustin, Jovenal T, Puligilla, Chandrakala, Chatterjee, Tania, Tansey, Terry, Liu, Xiaoqin, Kelley, Matthew W, Spiliotis, Elias T, Kwiatkowski, Adam V, Tuan, Rocky, Pazour, Gregory J, Hukriede, Neil A, Lo, Cecilia W

“…Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector…”
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Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases by Alexander, Peter G, Gottardi, Riccardo, Lin, Hang, Lozito, Thomas P, Tuan, Rocky S

“…Tissue engineered constructs have the potential to function as in vitro pre-clinical models of normal tissue function and disease pathogenesis for drug…”
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Endothelial cell microparticles act as centers of matrix metalloproteinsase-2 (MMP-2) activation and vascular matrix remodeling by Lozito, Thomas P., Tuan, Rocky S.

“…Endothelial cell (EC)‐derived microparticles (MPs) are small membrane vesicles associated with various vascular pathologies. Here, we investigated the role of…”
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Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors by Lozito, Thomas P., Tuan, Rocky S.

“…Tightly associated with blood vessels in their perivascular niche, human mesenchymal stem cells (MSCs) closely interact with endothelial cells (ECs). MSCs also…”
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Chromosome-level genome assembly and annotation of the crested gecko, Correlophus ciliatus, a lizard incapable of tail regeneration by Gumangan, Marc A., Pan, Zheyu, Lozito, Thomas P.

“…The vast majority of gecko species are capable of tail regeneration, but singular geckos of Correlophus, Uroplatus, and Nephrurus genera are unable to regrow…”
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Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis by Lozito, Thomas P, Alexander, Peter G, Lin, Hang, Gottardi, Riccardo, Cheng, Anthony Wai-Ming, Tuan, Rocky S

“…Osteoarthritis (OA), the most prevalent form of arthritis, affects up to 15% of the adult population and is principally characterized by degeneration of the…”
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Human mesenchymal stem cells express vascular cell phenotypes upon interaction with endothelial cell matrix by Lozito, Thomas P., Kuo, Catherine K., Taboas, Juan M., Tuan, Rocky S.

“…Mesenchymal stem cells (MSCs) are thought to occupy a perivascular niche where they are exposed to signals originating from vascular cells. This study focused…”
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Projection Stereolithographic Fabrication of BMP-2 Gene-activated Matrix for Bone Tissue Engineering by Lin, Hang, Tang, Ying, Lozito, Thomas P., Oyster, Nicholas, Kang, Robert B., Fritch, Madalyn R., Wang, Bing, Tuan, Rocky S.

“…Currently, sustained in vivo delivery of active bone morphogenetic protein-2 (BMP-2) protein to responsive target cells, such as bone marrow-derived…”
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Tissue Repair and Epimorphic Regeneration: an Overview by Londono, Ricardo, Sun, Aaron X., Tuan, Rocky S., Lozito, Thomas P.

“…Purpose of the Review This manuscript discusses wound healing as a component of epimorphic regeneration and the role of the immune system in this process…”
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Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue by Jackson, Wesley M., Lozito, Thomas P., Djouad, Farida, Kuhn, Nastaran Z., Nesti, Leon J., Tuan, Rocky S.

“…Mesenchymal stem cell (MSC) therapy is a promising approach to promote tissue regeneration by either differentiating the MSCs into the desired cell type or by…”
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