Search Results - "Lozada, John"

NK Cells from Human Cytomegalovirus-Seropositive Individuals Have a Distinct Metabolic Profile That Correlates with Elevated mTOR Signaling by Lozada, John R, Zhang, Bin, Miller, Jeffrey S, Cichocki, Frank

“…CMV can elicit adaptive immune features in both mouse and human NK cells. Mouse Ly49H+ NK cells expand 100- to 1000-fold in response to mouse CMV infection and…”
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Histologic spectrum of polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes by Sebastiao, Ana Paula Martins, Xu, Bin, Lozada, John R, Pareja, Fresia, Geyer, Felipe C, Da Cruz Paula, Arnaud, da Silva, Edaise M., Ghossein, Ronald A., Weinreb, Ilan, de Noronha, Lucia, Weigelt, Britta, Reis-Filho, Jorge S., Katabi, Nora

“…Polymorphous adenocarcinoma (PAC) and cribriform adenocarcinoma of (minor) salivary gland (CASG) are salivary gland tumors with overlapping spectrum of…”
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Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas by Geyer, Felipe C., Li, Anqi, Papanastasiou, Anastasios D., Smith, Alison, Selenica, Pier, Burke, Kathleen A., Edelweiss, Marcia, Wen, Huei-Chi, Piscuoglio, Salvatore, Schultheis, Anne M., Martelotto, Luciano G., Pareja, Fresia, Kumar, Rahul, Brandes, Alissa, Fan, Dan, Basili, Thais, Da Cruz Paula, Arnaud, Lozada, John R., Blecua, Pedro, Muenst, Simone, Jungbluth, Achim A., Foschini, Maria P., Wen, Hannah Y., Brogi, Edi, Palazzo, Juan, Rubin, Brian P., Ng, Charlotte K. Y., Norton, Larry, Varga, Zsuzsanna, Ellis, Ian O., Rakha, Emad A., Chandarlapaty, Sarat, Weigelt, Britta, Reis-Filho, Jorge S.

“…Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−myoepithelial differentiation, whose genetic underpinning is largely unknown…”
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ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors by Hong, Yeonsun, Walling, Brandon L., Kim, Hye-Ran, Serratelli, William S., Lozada, John R., Sailer, Cooper J., Amitrano, Andrea M., Lim, Kihong, Mongre, Raj Kumar, Kim, Kyun-Do, Capece, Tara, Lomakina, Elena B., Reilly, Nicholas S., Vo, Kevin, Gerber, Scott A., Fan, Tan-Chi, Yu, Alice Lin-Tsing, Oakes, Patrick W., Waugh, Richard E., Jun, Chang-Duk, Reagan, Patrick M., Kim, Minsoo

“…Adoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is becoming a promising treatment option for hematological malignancies…”
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Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors by Pareja, Fresia, Brandes, Alissa H., Basili, Thais, Selenica, Pier, Geyer, Felipe C., Fan, Dan, Da Cruz Paula, Arnaud, Kumar, Rahul, Brown, David N., Gularte-Mérida, Rodrigo, Alemar, Barbara, Bi, Rui, Lim, Raymond S., de Bruijn, Ino, Fujisawa, Sho, Gardner, Rui, Feng, Elvin, Li, Anqi, da Silva, Edaise M., Lozada, John R., Blecua, Pedro, Cohen-Gould, Leona, Jungbluth, Achim A., Rakha, Emad A., Ellis, Ian O., Edelweiss, Maria I. A., Palazzo, Juan, Norton, Larry, Hollmann, Travis, Edelweiss, Marcia, Rubin, Brian P., Weigelt, Britta, Reis-Filho, Jorge S.

“…Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations, and are characterized by abundant intracytoplasmic granules. The…”
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Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG): An International Interobserver Study by Xu, Bin, Barbieri, Andrea L., Bishop, Justin A., Chiosea, Simon I., Dogan, Snjezana, Di Palma, Silvana, Faquin, William C., Ghossein, Ronald, Hyrcza, Martin, Jo, Vickie Y., Lewis, James S., Lozada, John R., Michal, Michal, Pareja, Fresia G., Perez-Ordonez, Bayardo, Prasad, Manju L., Purgina, Bibianna, Reis-Filho, Jorge S., Scognamiglio, Theresa, Sebastiao, Ana P.M., Seethala, Raja R., Skálová, Alena, Smith, Stephen M., Tekkeşin, Merva S., Thompson, Lester D.R., Wasseman, Jason K., Wenig, Bruce M., Weinreb, Ilan, Katabi, Nora

“…Polymorphous adenocarcinoma (PAC) shows histologic diversity with streaming and targetoid features whereas cribriform adenocarcinoma of salivary gland (CASG)…”
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Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity by Pareja, Fresia, da Silva, Edaise M., Frosina, Denise, Geyer, Felipe C., Lozada, John R., Basili, Thais, Da Cruz Paula, Arnaud, Zhong, Elaine, Derakhshan, Fatemeh, D’Alfonso, Timothy, Wen, Hannah Y., Giri, Dilip D., Hayes, Malcolm M., Krings, Gregor, Bhargava, Rohit, Palazzo, Juan P., Rakha, Emad A., Hoda, Syed A., Sanders, Melinda E., Collins, Laura C., Schnitt, Stuart J., Chen, Yunn-Yi, Weigelt, Britta, Jungbluth, Achim A., Reis-Filho, Jorge S., Brogi, Edi

“…Tall cell carcinoma with reverse polarity is a rare subtype of breast carcinoma with solid and papillary growth and nuclear features reminiscent of those of…”
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Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (solid papillary carcinomas with reverse polarity) harbour recurrent mutations affecting IDH2 and PIK3CA: a validation cohort by Lozada, John R, Basili, Thais, Pareja, Fresia, Alemar, Barbara, Paula, Arnaud Da Cruz, Gularte‐Merida, Rodrigo, Giri, Dilip D, Querzoli, Patricia, Cserni, Gabor, Rakha, Emad A, Foschini, Maria P, Reis‐Filho, Jorge S, Brogi, Edi, Weigelt, Britta, Geyer, Felipe C

“…Aims Solid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with…”
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Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes by Hwang, Justin, Shi, Xiaolei, Elliott, Andrew, Arnoff, Taylor E, McGrath, Julie, Xiu, Joanne, Walker, Phillip, Bergom, Hannah E, Day, Abderrahman, Ahmed, Shihab, Tape, Sydney, Makovec, Allison, Ali, Atef, Shaker, Rami M, Toye, Eamon, Passow, Rachel, Lozada, John R, Wang, Jinhua, Lou, Emil, Mouw, Kent W, Carneiro, Benedito A, Heath, Elisabeth I, McKay, Rana R, Korn, W Michael, Nabhan, Chadi, Ryan, Charles J, Antonarakis, Emmanuel S

“…In patients with metastatic prostate cancer (mPC), ATM and BRCA2 mutations dictate differences in PARPi inhibitor response and other therapies. We interrogated…”
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Massively parallel sequencing analysis of benign melanocytic naevi by Lozada, John R, Geyer, Felipe C, Selenica, Pier, Brown, David, Alemar, Barbara, Merghoub, Taha, Berger, Michael F, Busam, Klaus J, Halpern, Allan C, Weigelt, Britta, Reis‐Filho, Jorge S, Hollmann, Travis J

“…Aims Melanocytic naevi are benign lesions of the skin or mucosa that may constitute non‐obligate precursors of malignant melanoma, particularly when they show…”
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Whole‐exome analysis of metaplastic breast carcinomas with extensive osseous differentiation by Beca, Francisco, Sebastiao, Ana P M, Pareja, Fresia, Dessources, Kimberly, Lozada, John R, Geyer, Felipe, Selenica, Pier, Zeizafoun, Nebras, Wen, Hannah Y, Norton, Larry, Brogi, Edi, Weigelt, Britta, Reis‐Filho, Jorge S

“…Aims Metaplastic breast carcinoma (MBC) is a rare type of triple‐negative breast cancer that shows vast histological and genetic heterogeneity. Osseous…”
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Myxoid fibroadenomas differ from conventional fibroadenomas: a hypothesis‐generating study by Lozada, John R, Burke, Kathleen A, Maguire, Aoife, Pareja, Fresia, Lim, Raymond S, Kim, Jisun, Gularte‐Merida, Rodrigo, Murray, Melissa P, Brogi, Edi, Weigelt, Britta, Reis‐Filho, Jorge S, Geyer, Felipe C

“…Aims Breast myxoid fibroadenomas (MFAs) are characterized by a distinctive hypocellular myxoid stroma, and occur sporadically or in the context of Carney…”
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Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes by Zorko, Nicholas A, Makovec, Allison, Elliott, Andrew, Kellen, Samuel, Lozada, John R, Arafa, Ali T, Felices, Martin, Shackelford, Madison, Barata, Pedro, Zakharia, Yousef, Narayan, Vivek, Stein, Mark N, Zarrabi, Kevin K, Patniak, Akash, Bilen, Mehmet A, Radovich, Milan, Sledge, George, El-Deiry, Wafik S, Heath, Elisabeth I, Hoon, Dave S B, Nabhan, Chadi, Miller, Jeffrey S, Hwang, Justin H, Antonarakis, Emmanuel S

“…Natural killer (NK) cells are non-antigen specific innate immune cells that can be redirected to targets of interest using multiple strategies, although none…”
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Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases by Ludwig, Megan L., Moline, David, Horrmann, Alec, Boytim, Ella, Larson, Gabrianne, Arafa, Ali T., Sayeda, Masooma, Lozada, John R., Bergom, Hannah E., Day, Abderrahman, Dasaraju, Sandhyarani, Dehm, Scott M., Murugan, Paari, Hwang, Justin, Drake, Justin M., Antonarakis, Emmanuel S.

“…Metastases to the brain are rare in prostate cancer. Here, we describe a patient with two treatment-emergent metastatic lesions, one to the brain with…”
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Divergent immune microenvironments in two tumor nodules from a patient with mismatch repair-deficient prostate cancer by Bergom, Hannah E., Sena, Laura A., Day, Abderrahman, Miller, Benjamin, Miller, Carly D., Lozada, John R., Zorko, Nicholas, Wang, Jinhua, Shenderov, Eugene, Lobo, Francisco Pereira, Caramella-Pereira, Fernanda, Marchionni, Luigi, Drake, Charles G., Lotan, Tamara, De Marzo, Angelo M., Hwang, Justin, Antonarakis, Emmanuel S.

“…Patients with prostate cancer (PC) generally do not respond favorably to immune checkpoint inhibitors, which may be due to a low abundance of…”
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ALAN is a computational approach that interprets genomic findings in the context of tumor ecosystems by Bergom, Hannah E., Shabaneh, Ashraf, Day, Abderrahman, Ali, Atef, Boytim, Ella, Tape, Sydney, Lozada, John R., Shi, Xiaolei, Kerkvliet, Carlos Perez, McSweeney, Sean, Pitzen, Samuel P., Ludwig, Megan, Antonarakis, Emmanuel S., Drake, Justin M., Dehm, Scott M., Ryan, Charles J., Wang, Jinhua, Hwang, Justin

“…Gene behavior is governed by activity of other genes in an ecosystem as well as context-specific cues including cell type, microenvironment, and prior exposure…”
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Pan-Cancer Interrogation of B7-H3 (CD276) as an Actionable Therapeutic Target across Human Malignancies by Miller, Carly D, Lozada, John R, Zorko, Nicholas A, Elliott, Andrew, Makovec, Allison, Radovich, Milan, Heath, Elisabeth I, Agarwal, Neeraj, McKay, Rana R, Garje, Rohan, Bastos, Bruno R, Hoon, Dave S, Orme, Jacob J, Sartor, Oliver, Vanderwalde, Ari, Nabhan, Chadi, Sledge, George W, Shenderov, Eugene, Dehm, Scott M, Lou, Emil, Miller, Jeffrey S, Hwang, Justin H, Antonarakis, Emmanuel S

“…B7-H3 (CD276) is a transmembrane glycoprotein of the B7 immune checkpoint superfamily that has emerged as a promising therapeutic target. To better understand…”
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318 Building A Better CAR: Improving CAR-T Trafficking in Cancer Therapy by Hong, Yeonsun, Kim, Hye-Ran, Walling, Brandon L., Lozada, John, Amitrano, Andrea M., Sailer, Cooper J., Lim, Kihong, Mongre, Raj Kumar, Kim, Kyun-Do, Capece, Tara, Lomakina, Elena B., Reilly, Nicholas S., Waugh, Richard E., Reagan, Patrick M., Kim, Minsoo, Oakes, Patrick W., Jun, Chang-Duk

“…OBJECTIVES/GOALS: #NAME? METHODS/STUDY POPULATION: Cell culture & protein identification: human T cells were purified from healthy blood, then activated &…”
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NK Cells from HCMV Seropositive Individuals Have a Distinct Metabolic Profile that Correlates with Elevated mTOR Signaling by Lozada, John R., Zhang, Bin, Miller, Jeffrey S., Cichocki, Frank

“…Cytomegalovirus (CMV) can elicit adaptive immune features in both mouse and human natural killer (NK) cells. Mouse Ly49H + NK cells expand 100- to 1,000-fold…”
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A Pan-Cancer Single-Cell Transcriptomic Atlas of Natural Killer (NK) Cells Reveals Intrinsic and Extrinsic Mediators of NK Cell Anti-Tumor Functions by Lozada, John R, Ali, Atef, Day, Abderrahman, Myers, Jacob A, Boytim, Ella, Bergom, Hannah, Zorko, Nicholas, Felices, Martin, Miller, Jeffrey S, Hwang, Justin, Cichocki, Frank

“…Background: Natural killer (NK) cells are critical mediators of anti-tumor immunity, engaging in direct cytotoxic responses and promoting pro-inflammatory…”
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