Search Results - "Loza, I. M."

Cytocompatibility and P‑glycoprotein Inhibition of Block Copolymers: Structure–Activity Relationship by Cambón, A, Brea, J, Loza, M. I, Alvarez-Lorenzo, C, Concheiro, A, Barbosa, S, Taboada, P, Mosquera, V

“…Amphiphilic polymeric micelles greatly improve the solubilization and sustained release of hydrophobic drugs and provide a protective environment for the cargo…”
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Intracellular delivery of docetaxel using freeze-dried polysaccharide nanocapsules by Lozano, M. V., Esteban, H., Brea, J., Loza, M. I., Torres, D., Alonso, M. J.

“…This article describes the development of a freeze-dried formulation of chitosan (CS) nanocapsules containing docetaxel (DCX) and the evaluation of its…”
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Poly(styrene oxide)-poly(ethylene oxide) block copolymers: From “classical” chemotherapeutic nanocarriers to active cell-response inducers by Cambón, A., Rey-Rico, A., Barbosa, S., Soltero, J.F.A., Yeates, S.G., Brea, J., Loza, M.I., Alvarez-Lorenzo, C., Concheiro, A., Taboada, P., Mosquera, V.

“…Two poly(styrene oxide)–poly(ethylene oxide) (PSO–PEO) triblock copolymers with different chain lengths were analyzed as potential chemotherapeutic…”
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Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: A comparative study by Varela, M.J, Lage, S, Caruncho, H.J, Cadavid, M.I, Loza, M.I, Brea, J

“…Highlights • There is an increased D2 and 5-HT2A receptor density in HRM striatum. • There is a decreased D2 and 5-HT2A receptor density in HRM frontal cortex…”
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Environmental aspects of the effect of earthworm (Lumbricidae, Oligochaeta) tropho-metabolic activity on the pH buffering capacity of remediated soil (steppe zone, Ukraine) by Kul’bachko, Y. L, Didur, O. O, Loza, I. M, Pakhomov, O. E, Bezrodnova, O. V

“…Environmental aspects of tropho-metabolic activity of soil saprophages on the pH-buffering capacity of remediated soils in Ukraine was considered. Earthworm…”
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Chitosan–hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma by Oyarzun-Ampuero, F.A., Brea, J., Loza, M.I., Torres, D., Alonso, M.J.

“…The purpose of this study was to produce mucoadhesive nanocarriers made from chitosan (CS) and hyaluronic acid (HA), and containing the macromolecular drug…”
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A New Family of Subnanomolar inhibitors of Soluble Epoxide Hydrolase by Escolano, Carmen, Bagan, Andrea, Turcu, Andreea L., Morisseau, Christophe, Loza, M. I., Brea, Jose, Bartra, Clara, Sanfeliu, Coral, Hammock, Bruce D., Vázquez, Santiago

“…The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases…”
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In vitro models for neuropathic pain phenotypic screening in brain therapeutics by Martínez, A.L., Brea, J., López, D., Cosme, N., Barro, M., Monroy, X., Burgueño, J., Merlos, M., Loza, M.I.

“…The discovery of brain therapeutics faces a significant challenge due to the low translatability of preclinical results into clinical success. To address this…”
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Soluble Epoxide Hydrolase Inhibitors: Design, Synthesis, in vitro Profiling and in vivo Evaluation in Murine Models of Pain by Vázquez, Santiago, Codony, Sandra, Entrena, José M., Jora, Beatrice, González‐Cano, Rafael, Loza, M. I., Brea, Jose, Morisseau, Christophe, Bartra, Clara, Sanfeliu, Coral, Hammock, Bruce D., Cobos, Enrique J.

“…Epoxyeicosatrienoic acids (EETs) are endogenous chemical mediators that show anti‐inflammatory, antihypertensive, and analgesic effects. Soluble epoxide…”
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Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor by Cimadevila, M., Gómez-García, L., Martínez, A.L., Iglesias, A., López-Giménez, J., Castro, M., Cadavid, M.I., Loza, M.I., Brea, J.

“…[Display omitted] The 5-HT2A receptor is a homodimeric G protein-coupled receptor implied in multiple diseases, including schizophrenia. Recently, its…”
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Impact of invasive species Parectopa robiniella (Gracillariidae) on fluorescence parameters of Robinia pseudoacacia in the conditions of the steppe zone of Ukraine by Holoborodko, K. K., Sytnyk, S. A., Lovynska, V. M., Ivanko, I. A., Loza, I. M., Brygadyrenko, V. V.

“…Robinia pseudoacacia L. is one of the most common and environmentally adaptable introduced tree species which has become an important element of artificial…”
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Doxorubicin-loaded micelles of reverse poly(butylene oxide)–poly(ethylene oxide)–poly(butylene oxide) block copolymers as efficient “active” chemotherapeutic agents by Cambón, A., Rey-Rico, A., Mistry, D., Brea, J., Loza, M.I., Attwood, D., Barbosa, S., Alvarez-Lorenzo, C., Concheiro, A., Taboada, P., Mosquera, V.

“…Five reverse poly(butylene oxide)–poly(ethylene oxide)–poly(butylene oxide) block copolymers, BOnEOmBOn, with BO ranging from 8 to 21units and EO from 90 to…”
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Product Monographs Supplied by Drug Manufacturers to Community Pharmacists in Spain by Fernández-Llimós, Fernando, Loza, María I

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New arylpiperazine derivatives with high affinity for α1A, D2 and 5-HT2A receptors by GONZALEZ-GOMEZ, J. C, SANTANA, L, URIARTE, E, BREA, J, VILLAZON, M, LOZA, M. I, DE LUCA, M, RIVAS, M. E, MONTENEGRO, G. Y, FONTENLA, J. A

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Information technology in community pharmacies for supporting responsible self-medication by SANZ, F, SILVEIRA, C, CRANZ, H, HENDERSON, K, MIRCHEVA, J, FERNANDEZ, J. L, DIAZ, C, ALONSO, A, LOZA, M. I, CORDERO, L, FERNANDEZ-LLIMOS, F, CADAVID, M. I, TIDDENS, L, GIORGIO, F

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Study of the mechanism of the relaxant action of (+)‐glaucine in rat vas deferens by Orallo, Francisco, Alzueta, Alejandro Fdez, Loza, M. Isabel, Vivas, Nuria, Badía, Albert, Campos, Manuel, Honrubia, M. Angeles, Cadavid, M. Isabel

“…1 Effects of the aporphinoid alkaloid, (+)‐glaucine, on rat vas deferens were investigated. 2 (+)‐Glaucine (2–18 μm) competitively inhibited contractions…”
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Antiserotoninergic activity of 2-aminoethylbenzocyclanones in rat aorta: structure-activity relationships by Loza, M I, Ferreiro, T G, Sanz, F, Lozoya, E, Rodriguez, J, Manaut, F, Verde, I, Castro, E, Fontenla, J A, Cadavid, I

“…The antiserotoninergic activity at the serotonin receptor subtype 2 (5-HT2) of seven new 2-aminoethylbenzocyclanones was determined with respect to…”
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Multiple conformations of native and recombinant human 5-hydroxytryptamine(2a) receptors are labeled by agonists and discriminated by antagonists by López-Giménez, J F, Villazón, M, Brea, J, Loza, M I, Palacios, J M, Mengod, G, Vilaró, M T

“…We have expanded previous studies with the 5-hydroxytryptamine (5-HT)(2) receptor agonist (+/-)-1-(2,5-dimethoxy-4-[(125)I]iodophenyl)-2-aminopropane…”
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Cyproheptadine analogues: synthesis, antiserotoninergic activity, and structure-activity relationships by Loza, M I, Sanz, F, Cadavid, M I, Honrubia, M, Orallo, F, Fontenla, J A, Calleja, J M, Dot, T, Manaut, F, Cid, M M

“…A series of cyproheptadine related compounds was synthesized and tested pharmacologically. In comparison with cyproheptadine, these compounds do not have a…”
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Synthesis, Affinity at 5-HT2A, 5-HT2B and 5-HT2C Serotonin Receptors and Structure-Activity Relationships of a Series of Cyproheptadine Analogues by HONRUBIA, Maria Angeles, RODRIGUEZ, Jesus, DOMINGUEZ, Rosa, LOZOYA, Estrella, MANAUT, Francesc, SEIJAS, Julio A., VILLAVERDE, Maria Carmen, CALLEJA, Jose M., CADAVID, Maria Isabel, MAAYANI, Saul, SANZ, Ferran, LOZA, Maria Isabel

“…Cyproheptadine is a drug that shows high affinity for type 2 (5-HT2) receptors. We studied a series of compounds obtained by modification of the tricyclic…”
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