Search Results - "Loza, I"

Identification and characterization of Cardiac Glycosides as senolytic compounds by Triana-Martínez, Francisco, Picallos-Rabina, Pilar, Da Silva-Álvarez, Sabela, Pietrocola, Federico, Llanos, Susana, Rodilla, Verónica, Soprano, Enrica, Pedrosa, Pablo, Ferreirós, Alba, Barradas, Marta, Hernández-González, Fernanda, Lalinde, Marta, Prats, Neus, Bernadó, Cristina, González, Patricia, Gómez, María, Ikonomopoulou, Maria P., Fernández-Marcos, Pablo J., García-Caballero, Tomás, del Pino, Pablo, Arribas, Joaquín, Vidal, Anxo, González-Barcia, Miguel, Serrano, Manuel, Loza, María I., Domínguez, Eduardo, Collado, Manuel

“…Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic…”
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A Positive Allosteric Modulator of the Serotonin 5‑HT2C Receptor for Obesity by García-Cárceles, Javier, Decara, Juan M., Vázquez-Villa, Henar, Rodríguez, Ramón, Codesido, Eva, Cruces, Jacobo, Brea, José, Loza, María I., Alén, Francisco, Botta, Joaquin, McCormick, Peter J., Ballesteros, Juan A., Benhamú, Bellinda, Rodríguez de Fonseca, Fernando, López-Rodríguez, María L.

“…The 5-HT2CR agonist lorcaserin, clinically approved for the treatment of obesity, causes important side effects mainly related to subtype selectivity. In the…”
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5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines by Toro-Sazo, Miguel, Brea, José, Loza, María I, Cimadevila, Marta, Cassels, Bruce K

“…The last fifteen years have seen the emergence and overflow into the drug scene of "superpotent" N-benzylated phenethylamines belonging to the "NBOMe" series,…”
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Forced Axisymmetric Vibrations of an Electrically Excited Hollow Sphere Made of a Continuously Inhomogeneous Piezoceramic Material by Grigorenko, A. Ya, Loza, I. A.

“…The forced axisymmetric vibrations of a hollow sphere made of a functionally graded radially polarized piezocelectric material are studied using the spatial…”
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2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives by Areias, Filipe, Correia, Carla, Rocha, Ashly, Teixeira, Sofia, Castro, Marián, Brea, Jose, Hu, Huabin, Carlsson, Jens, Loza, Maria I, Proença, M Fernanda, Carvalho, M Alice

“…A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A , A , A , and A…”
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A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade by Izquierdo, Irene, Barrachina, María N, Hermida-Nogueira, Lidia, Casas, Vanessa, Morán, Luis A, Lacerenza, Serena, Pinto-Llorente, Roberto, Eble, Johannes A, de Los Ríos, Vivian, Domínguez, Eduardo, Loza, María I, Casal, José Ignacio, Carrascal, Montserrat, Abián, Joaquín, García, Angel

“…C-type lectin-like receptor 2 (CLEC-2) plays a crucial role in different platelet-related physiological and pathological processes. It signals through a…”
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Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents by Prieto-Díaz, Rubén, Fojo-Carballo, Hugo, Majellaro, Maria, Tandarić, Tana, Azuaje, Jhonny, Brea, José, Loza, María I., Barbazán, Jorge, Salort, Glòria, Chotalia, Meera, Rodríguez-Pampín, Iván, Mallo-Abreu, Ana, Rita Paleo, M., García-Mera, Xerardo, Ciruela, Francisco, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy

“…Antagonists of the A2B adenosine receptor have recently emerged as targeted anticancer agents and immune checkpoint inhibitors within the realm of cancer…”
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Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2‑Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates by Carbajales, Carlos, Azuaje, Jhonny, Oliveira, Ana, Loza, María I, Brea, José, Cadavid, María I, Masaguer, Christian F, García-Mera, Xerardo, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy

“…A novel family of structurally simple, potent, and selective nonxanthine A2BAR ligands was identified, and its antagonistic behavior confirmed through…”
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Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy by Nogueira-Recalde, Uxía, Lorenzo-Gómez, Irene, Blanco, Francisco J., Loza, María I., Grassi, Diego, Shirinsky, Valery, Shirinsky, Ivan, Lotz, Martin, Robbins, Paul D., Domínguez, Eduardo, Caramés, Beatriz

“…Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying…”
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Mature Andean forests as globally important carbon sinks and future carbon refuges by Duque, Alvaro, Peña, Miguel A., Cuesta, Francisco, González-Caro, Sebastián, Kennedy, Peter, Phillips, Oliver L., Calderón-Loor, Marco, Blundo, Cecilia, Carilla, Julieta, Cayola, Leslie, Farfán-Ríos, William, Fuentes, Alfredo, Grau, Ricardo, Homeier, Jürgen, Loza-Rivera, María I., Malhi, Yadvinder, Malizia, Agustina, Malizia, Lucio, Martínez-Villa, Johanna A., Myers, Jonathan A., Osinaga-Acosta, Oriana, Peralvo, Manuel, Pinto, Esteban, Saatchi, Sassan, Silman, Miles, Tello, J. Sebastián, Terán-Valdez, Andrea, Feeley, Kenneth J.

“…It is largely unknown how South America’s Andean forests affect the global carbon cycle, and thus regulate climate change. Here, we measure aboveground carbon…”
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Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug by Pflüger, Pricila, Pereira, Patrícia, Loza, María I., Brea, José, Viña, Dolores, Kumar, Amit, Fontenla, José A.

“…Treatment of Parkinson's disease (PD) includes the use of monoamine oxidase-B (MAO-B) inhibitor drugs. In this work we have evaluated the possible…”
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Effect of Electrical Boundary Conditions and Direction of Polarization of Piezoceramics on Spectral Characteristics of Axisymmetric Acoustoelectric Waves in Hollow Cylinder by Grigorenko, O. Ya, Loza, I. A., Melnyk, V. M., Sperkach, S. O.

“…The propagation of axisymmetric waves in a hollow homogeneous piezoceramic cylinder with different electrical boundary conditions on the lateral surfaces is…”
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Lentiviral Vectors for the Treatment and Prevention of Cystic Fibrosis Lung Disease by Marquez Loza, Laura I, Yuen, Eric C, McCray, Jr, Paul B

“…Despite the continued development of cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs for the treatment of cystic fibrosis (CF), the…”
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A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice by Companys-Alemany, Júlia, Turcu, Andreea L, Bellver-Sanchis, Aina, Loza, Maria I, Brea, José M, Canudas, Anna M, Leiva, Rosana, Vázquez, Santiago, Pallàs, Mercè, Griñán-Ferré, Christian

“…Alzheimer's disease (AD) is the leading cause of dementia. Non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist memantine improved cognition and…”
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Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition by Mallo-Abreu, Ana, Majellaro, María, Jespers, Willem, Azuaje, Jhonny, Caamaño, Olga, García-Mera, Xerardo, Brea, José M, Loza, María I, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy

“…We report the identification of two subsets of fluorinated nonxanthine A2B adenosine receptor antagonists. The novel derivatives explore the effect of…”
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Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists by Prieto-Díaz, Rubén, González-Gómez, Manuel, Fojo-Carballo, Hugo, Azuaje, Jhonny, El Maatougui, Abdelaziz, Majellaro, Maria, Loza, María I., Brea, José, Fernández-Dueñas, Víctor, Paleo, M. Rita, Díaz-Holguín, Alejandro, Garcia-Pinel, Beatriz, Mallo-Abreu, Ana, Estévez, Juan C., Andújar-Arias, Antonio, García-Mera, Xerardo, Gomez-Tourino, Iria, Ciruela, Francisco, Salas, Cristian O., Gutiérrez-de-Terán, Hugo, Sotelo, Eddy

“…The modulation of the A2B adenosine receptor is a promising strategy in cancer (immuno) therapy, with A2BAR antagonists emerging as immune checkpoint…”
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The PI3Kδ Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential by Barrachina, María N, Izquierdo, Irene, Hermida-Nogueira, Lidia, Morán, Luis A, Pérez, Amparo, Arroyo, Ana B, García-Barberá, Nuria, González-Conejero, Rocío, Troitiño, Sara, Eble, Johannes A, Rivera, José, Martínez, Constantino, Loza, María I, Domínguez, Eduardo, García, Ángel

“…Clinical management of ischemic events and prevention of vascular disease is based on antiplatelet drugs. Given the relevance of…”
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Exploring the Effect of Halogenation in a Series of Potent and Selective A 2B Adenosine Receptor Antagonists by Prieto-Díaz, Rubén, González-Gómez, Manuel, Fojo-Carballo, Hugo, Azuaje, Jhonny, El Maatougui, Abdelaziz, Majellaro, Maria, Loza, María I, Brea, José, Fernández-Dueñas, Víctor, Paleo, M Rita, Díaz-Holguín, Alejandro, Garcia-Pinel, Beatriz, Mallo-Abreu, Ana, Estévez, Juan C, Andújar-Arias, Antonio, García-Mera, Xerardo, Gomez-Tourino, Iria, Ciruela, Francisco, Salas, Cristian O, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy

“…The modulation of the A adenosine receptor is a promising strategy in cancer (immuno) therapy, with A AR antagonists emerging as immune checkpoint inhibitors…”
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder by Lacivita, Enza, Niso, Mauro, Mastromarino, Margherita, Garcia Silva, Andrea, Resch, Cibell, Zeug, Andre, Loza, María I, Castro, Marián, Ponimaskin, Evgeni, Leopoldo, Marcello

“…Autism spectrum disorder (ASD) includes a group of neurodevelopmental disorders characterized by core symptoms such as impaired social interaction and…”
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Discovery of V‑0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide‑1 Receptor toward Oral Treatment for “Diabesity” by Decara, Juan M, Vázquez-Villa, Henar, Brea, José, Alonso, Mónica, Srivastava, Raj Kamal, Orio, Laura, Alén, Francisco, Suárez, Juan, Baixeras, Elena, García-Cárceles, Javier, Escobar-Peña, Andrea, Lutz, Beat, Rodríguez, Ramón, Codesido, Eva, Garcia-Ladona, F. Javier, Bennett, Teresa A, Ballesteros, Juan A, Cruces, Jacobo, Loza, María I, Benhamú, Bellinda, Rodríguez de Fonseca, Fernando, López-Rodríguez, María L

“…Peptidic agonists of the glucagon-like peptide-1 receptor (GLP-1R) have gained a prominent role in the therapy of type-2 diabetes and are being considered for…”
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