Search Results - "Loza, Andrew J."

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis by Ruhland, Megan K., Loza, Andrew J., Capietto, Aude-Helene, Luo, Xianmin, Knolhoff, Brett L., Flanagan, Kevin C., Belt, Brian A., Alspach, Elise, Leahy, Kathleen, Luo, Jingqin, Schaffer, Andras, Edwards, John R., Longmore, Gregory, Faccio, Roberta, DeNardo, David G., Stewart, Sheila A.

“…Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To…”
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Crawling toward obsolescence: The extended lifespan of amylase for pancreatitis by Kanaparthy, Naga Sasidhar, Loza, Andrew J, Hauser, Ronald George

“…The correlation between hyperamylasemia and acute pancreatitis was discovered in 1929, yet another test, lipase, was shown to provide better diagnostic…”
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Predicting physician departure with machine learning on EHR use patterns: A longitudinal cohort from a large multi-specialty ambulatory practice by Lopez, Kevin, Li, Huan, Paek, Hyung, Williams, Brian, Nath, Bidisha, Melnick, Edward R, Loza, Andrew J

“…Physician turnover places a heavy burden on the healthcare industry, patients, physicians, and their families. Having a mechanism in place to identify…”
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Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development by Luo, Xianmin, Fu, Yujie, Loza, Andrew J., Murali, Bhavna, Leahy, Kathleen M., Ruhland, Megan K., Gang, Margery, Su, Xinming, Zamani, Ali, Shi, Yu, Lavine, Kory J., Ornitz, David M., Weilbaecher, Katherine N., Long, Fanxin, Novack, Deborah V., Faccio, Roberta, Longmore, Gregory D., Stewart, Sheila A.

“…More than 85% of advanced breast cancer patients suffer from metastatic bone lesions, yet the mechanisms that facilitate these metastases remain poorly…”
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The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis by Corsa, Callie A.S., Brenot, Audrey, Grither, Whitney R., Van Hove, Samantha, Loza, Andrew J., Zhang, Kun, Ponik, Suzanne M., Liu, Yuming, DeNardo, David G., Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.

“…High levels of collagen deposition in human and mouse breast tumors are associated with poor outcome due to increased local invasion and distant metastases…”
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Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival by Tinkum, Kelsey L., Stemler, Kristina M., White, Lynn S., Loza, Andrew J., Jeter-Jones, Sabrina, Michalski, Basia M., Kuzmicki, Catherine, Pless, Robert, Stappenbeck, Thaddeus S., Piwnica-Worms, David, Piwnica-Worms, Helen

“…Short-term fasting protects mice from lethal doses of chemotherapy through undetermined mechanisms. Herein, we demonstrate that fasting preserves small…”
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AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol by Jagannathan, Radhika, Schimizzi, Gregory V., Zhang, Kun, Loza, Andrew J., Yabuta, Norikazu, Nojima, Hitoshi, Longmore, Gregory D.

“…The Hippo pathway controls organ growth and is implicated in cancer development. Whether and how Hippo pathway activity is limited to sustain or initiate cell…”
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Cell density and actomyosin contractility control the organization of migrating collectives within an epithelium by Loza, Andrew J, Koride, Sarita, Schimizzi, Gregory V, Li, Bo, Sun, Sean X, Longmore, Gregory D

“…The mechanisms underlying collective migration are important for understanding development, wound healing, and tumor invasion. Here we focus on cell density to…”
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Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility by Koride, Sarita, Loza, Andrew J., Sun, Sean X.

“…Collective motions of groups of cells are observed in many biological settings such as embryo development, tissue formation, and cancer metastasis. To…”
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Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms by Schimizzi, Gregory V, Maher, Meghan T, Loza, Andrew J, Longmore, Gregory D

“…The establishment and maintenance of apical-basal polarity is a defining characteristic and essential feature of functioning epithelia. Apical-basal polarity…”
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Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory by Nasrollahi, Samila, Walter, Christopher, Loza, Andrew J., Schimizzi, Gregory V., Longmore, Gregory D., Pathak, Amit

“…During morphogenesis and cancer metastasis, grouped cells migrate through tissues of dissimilar stiffness. Although the influence of matrix stiffness on…”
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The Effect of COVID-19 Pandemic Restrictions on Lead Screening in a Primary Care Clinic by Loza, Andrew J., Doolittle, Benjamin R.

“…Coronavirus disease 2019 (COVID-19) has disrupted outpatient pediatrics, postponing well-child care to address immediate patient safety concerns. Screening for…”
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Rates of Body Mass Index Increase in Children During the COVID-19 Pandemic by Loza, Andrew J, Child, Isabella, Doolittle, Benjamin R

“…Pediatric obesity is a significant public health concern, and the COVID-19 pandemic altered many of its risk factors. Understanding this impact can help…”
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TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis by Grither, Whitney R., Divine, Laura M., Meller, Eric H., Wilke, Daniel J., Desai, Riva A., Loza, Andrew J., Zhao, Peinan, Lohrey, Anne, Longmore, Gregory D., Fuh, Katherine C.

“…The mesenchymal gene program has been shown to promote the metastatic progression of ovarian cancer; however, specific proteins induced by this program that…”
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PROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data by Iscoe, Mark S, Loza, Andrew J, Turbiville, Donald, Campbell, Sheldon M, Peaper, David R, Balbuena-Merle, Raisa I, Hauser, Ronald G

“…Abstract Objectives Peripheral blood smear (PBS) interpretation represents a cornerstone of pathology practice and resident training but has remained largely…”
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Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II by Yashiro, Hanako, Loza, Andrew J, Skeath, James B, Longmore, Gregory D

“…Once adherens junctions (AJs) are formed between polarized epithelial cells they must be maintained because AJs are constantly remodeled in dynamic epithelia…”
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Adoption of Emergency Department-Initiated Buprenorphine for Patients With Opioid Use Disorder: Secondary Analysis of a Cluster Randomized Trial by Gao, Evangeline, Melnick, Edward R, Paek, Hyung, Nath, Bidisha, Taylor, R Andrew, Loza, Andrew J

“…Emergency department (ED) initiation of buprenorphine is safe and effective but underutilized in practice. Understanding the factors affecting adoption of this…”
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Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis by Li-Villarreal, Nanbing, Forbes, Meredyth M, Loza, Andrew J, Chen, Jiakun, Ma, Taylur, Helde, Kathryn, Moens, Cecilia B, Shin, Jimann, Sawada, Atsushi, Hindes, Anna E, Dubrulle, Julien, Schier, Alexander F, Longmore, Gregory D, Marlow, Florence L, Solnica-Krezel, Lilianna

“…Dachsous (Dchs), an atypical cadherin, is an evolutionarily conserved regulator of planar cell polarity, tissue size and cell adhesion. In humans, DCHS1…”
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Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis by Li-Villarreal, Nanbing, Forbes, Meredyth M, Loza, Andrew J, Chen, Jiakun, Ma, Taylur, Helde, Kathryn, Moens, Cecilia B, Shin, Jimann, Sawada, Atsushi, Hindes, Anna E, Dubrulle, Julien, Schier, Alexander F, Longmore, Gregory D, Marlow, Florence L, Solnica-Krezel, Lilianna

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Using Panel Management to Identify Adult Patients With High-Risk Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis Fibrosis in a Primary Care Clinic: A Pilot Study by Householder, Sarah, Loza, Andrew J, Gupta, Vikas, Doolittle, Benjamin R

“…As rates of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) rise, national…”
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