Search Results - "Loy, Clement"

Circular RNAs: The Brain Transcriptome Comes Full Circle by Gokool, Akira, Loy, Clement T., Halliday, Glenda M., Voineagu, Irina

“…Circular RNAs (circRNAs) are a class of RNA molecules with a covalently closed loop structure formed by back-splicing of exon–exon junctions. The detection of…”
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Genetics of dementia by Loy, Clement T, FRACP, Schofield, Peter R, Prof, Turner, Anne M, FRACP, Kwok, John BJ, Dr

“…Summary 25% of all people aged 55 years and older have a family history of dementia. For most, the family history is due to genetically complex disease, where…”
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Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders by Werry, Eryn L, Bright, Fiona M, Piguet, Olivier, Ittner, Lars M, Halliday, Glenda M, Hodges, John R, Kiernan, Matthew C, Loy, Clement T, Kril, Jillian J, Kassiou, Michael

“…Neuroinflammation is an inflammatory response in the brain and spinal cord, which can involve the activation of microglia and astrocytes. It is a common…”
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Prevalent Nonmotor Symptoms Associated With Huntington Disease: Challenging to Interpret and With Early Impact on Function by McCusker, Elizabeth Anne, Loy, Clement T.

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Scientific, Ethical, and Practical Considerations for the Testing and Disclosure of Alzheimer Disease Biomarkers by McCusker, Elizabeth A., Loy, Clement T.

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Neuroinflammation in frontotemporal dementia by Bright, Fiona, Werry, Eryn L., Dobson-Stone, Carol, Piguet, Olivier, Ittner, Lars M., Halliday, Glenda M., Hodges, John R., Kiernan, Matthew C., Loy, Clement T., Kassiou, Michael, Kril, Jillian J.

“…Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative disorders with different pathological signatures, genetic variability and…”
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Apathy and Depression in Huntington’s Disease: Distinct Longitudinal Trajectories and Clinical Correlates by Connors, Michael H., Teixeira-Pinto, Armando, Loy, Clement T.

“…Objective:Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disease resulting in motor disturbances, dementia, and psychiatric symptoms…”
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Psychosis and longitudinal outcomes in Huntington disease: the COHORT Study by Connors, Michael H, Teixeira-Pinto, Armando, Loy, Clement T

“…ObjectiveHuntington disease (HD) is an autosomal dominant neurodegenerative disease involving motor disturbances, cognitive decline and psychiatric symptoms…”
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Causal Relationship Between Kidney Function and Cancer Risk: A Mendelian Randomization Study by Dobrijevic, Ellen, van Zwieten, Anita, Grant, Andrew J., Loy, Clement T., Craig, Jonathan C., Teixeira-Pinto, Armando, Wong, Germaine

“…Patients treated with kidney replacement therapy experience a 1.5- to 2-fold increased risk of cancer and cancer mortality compared with the general…”
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The complex relationship between genotype, pathology and phenotype in familial dementia by Kwok, John B., Loy, Clement T., Dobson-Stone, Carol, Halliday, Glenda M.

“…Causative genes involved in familial forms of dementias, including Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) and dementia with Lewy…”
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A meta-analysis of hippocampal atrophy rates in Alzheimer's disease by Barnes, Josephine, Bartlett, Jonathan W, van de Pol, Laura A, Loy, Clement T, Scahill, Rachael I, Frost, Chris, Thompson, Paul, Fox, Nick C

“…Abstract Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer's disease (AD). However, cohorts and methods used to determine such…”
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Awaji Criteria Improves the Diagnostic Sensitivity in Amyotrophic Lateral Sclerosis: a Systematic Review Using Individual Patient Data by Geevasinga, Nimeshan, Loy, Clement T, Menon, Parvathi, de Carvalho, Mamede, Swash, Michael, Schrooten, Maarten, Van Damme, Philip, Gawel, Malgorzata, Sonoo, Masahiro, Higashihara, Mana, Noto, Yu-ichi, Kuwabara, Satoshi, Kiernan, Matthew C, Macaskill, Petra, Vucic, Steve

“…Highlights • Individual patient data analysis disclosed a higher sensitivity of the Awaji criteria when compared with the revised El Escorial criteria. •…”
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Why aren't people with young onset dementia and their supporters using formal services? Results from the INSPIRED study by Cations, Monica, Withall, Adrienne, Horsfall, Ruth, Denham, Nicole, White, Fiona, Trollor, Julian, Loy, Clement, Brodaty, Henry, Sachdev, Perminder, Gonski, Peter, Demirkol, Apo, Cumming, Robert G, Draper, Brian

“…Despite reporting high levels of burden, supporters of people with young onset dementia (YOD) underuse formal community services. Previous quantitative studies…”
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Robust Optimization and Data Classification for Characterization of Huntington Disease Onset via Duality Methods by Woolnough, Daniel, Jeyakumar, Niroshan, Li, Guoyin, Loy, Clement T, Jeyakumar, Vaithilingam

“…The features that characterize the onset of Huntington disease (HD) are poorly understood yet have significant implications for research and clinical practice…”
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Prevalence and patterns of cognitive impairment in adult hemodialysis patients: the COGNITIVE-HD study by van Zwieten, Anita, Wong, Germaine, Ruospo, Marinella, Palmer, Suetonia C, Barulli, Maria Rosaria, Iurillo, Annalisa, Saglimbene, Valeria, Natale, Patrizia, Gargano, Letizia, Murgo, Marco, Loy, Clement T, Tortelli, Rosanna, Craig, Jonathan C, Johnson, David W, Tonelli, Marcello, Hegbrant, Jörgen, Wollheim, Charlotta, Logroscino, Giancarlo, Strippoli, Giovanni F M

“…Mounting evidence indicates an increased risk of cognitive impairment in adults with end-stage kidney disease on dialysis, but the extent and pattern of…”
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C9ORF72 repeat expansion in Australian and Spanish frontotemporal dementia patients by Dobson-Stone, Carol, Hallupp, Marianne, Loy, Clement T, Thompson, Elizabeth M, Haan, Eric, Sue, Carolyn M, Panegyres, Peter K, Razquin, Cristina, Seijo-Martínez, Manuel, Rene, Ramon, Gascon, Jordi, Campdelacreu, Jaume, Schmoll, Birgit, Volk, Alexander E, Brooks, William S, Schofield, Peter R, Pastor, Pau, Kwok, John B J

“…A hexanucleotide repeat expansion in C9ORF72 has been established as a common cause of frontotemporal dementia (FTD). However, the minimum repeat number…”
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Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation by Katzeff, Jared S., Bright, Fiona, Lo, Kitty, Kril, Jillian J., Connolly, Angela, Crossett, Ben, Ittner, Lars M., Kassiou, Michael, Loy, Clement T., Hodges, John R., Piguet, Olivier, Kiernan, Matthew C., Halliday, Glenda M., Kim, Woojin Scott

“…Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases that are considered to be on the same disease spectrum…”
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Making Decisions About Long-Term Institutional Care Placement Among People With Dementia and Their Caregivers: Systematic Review of Qualitative Studies by Teng, Claris, Loy, Clement T, Sellars, Marcus, Pond, Dimity, Latt, Mark D, Waite, Louise M, Sinka, Victoria, Logeman, Charlotte, Tong, Allison

“…Abstract Background and Objectives People with dementia become increasingly dependent on others for care as cognition declines. Decision making about placement…”
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What do we know about Late Onset Huntington's Disease? by Chaganti, Sai S, McCusker, Elizabeth A, Loy, Clement T

“…Although the typical age of onset for Huntington's disease (HD) is in the fourth decade, between 4.4-11.5% of individuals with HD have a late onset (over 60…”
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The many facets of unawareness in huntington disease by McCusker, Elizabeth, Loy, Clement T

“…BACKGROUNDUnawareness or diminished awareness is present when a patient's perception of obvious disease manifestations and impact differ from that of observers…”
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