Search Results - "Lowther, W."

Chemical proteomics reveals new targets of cysteine sulfinic acid reductase by Akter, Salma, Fu, Ling, Jung, Youngeun, Conte, Mauro Lo, Lawson, J. Reed, Lowther, W. Todd, Sun, Rui, Liu, Keke, Yang, Jing, Carroll, Kate S.

“…Cysteine sulfinic acid or S -sulfinylation is an oxidative post-translational modification (OxiPTM) that is known to be involved in redox-dependent regulation…”
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Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins by Bolduc, Jesalyn A., Nelson, Kimberly J., Haynes, Alexina C., Lee, Jingyun, Reisz, Julie A., Graff, Aaron H., Clodfelter, Jill E., Parsonage, Derek, Poole, Leslie B., Furdui, Cristina M., Lowther, W. Todd

“…2-Cys peroxiredoxins (Prxs) modulate hydrogen peroxide (H2O2)-mediated cell signaling. At high H2O2 levels, eukaryotic Prxs can be inactivated by…”
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Substrate specificity and membrane topologies of the iron-containing ω3 and ω6 desaturases from Mortierella alpina by Wang, Mingxuan, Chen, Haiqin, Ailati, Aisikaer, Chen, Wei, Chilton, Floyd H., Todd Lowther, W., Chen, Yong Q.

“…Polyunsaturated fatty acids (PUFAs) are essential lipids for cell function, normal growth, and development, serving as key structural components of biological…”
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Reduction of cysteine sulfinic acid in eukaryotic, typical 2-Cys peroxiredoxins by sulfiredoxin by Lowther, W Todd, Haynes, Alexina C

“…The eukaryotic, typical 2-Cys peroxiredoxins (Prxs) are inactivated by hyperoxidation of one of their active-site cysteine residues to cysteine sulfinic acid…”
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Hydroxyproline Metabolism and Oxalate Synthesis in Primary Hyperoxaluria by Fargue, Sonia, Milliner, Dawn S, Knight, John, Olson, Julie B, Lowther, W Todd, Holmes, Ross P

“…Endogenous oxalate synthesis contributes to calcium oxalate stone disease and is markedly increased in the inherited primary hyperoxaluria (PH) disorders. The…”
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End Points for Clinical Trials in Primary Hyperoxaluria by Milliner, Dawn S, McGregor, Tracy L, Thompson, Aliza, Dehmel, Bastian, Knight, John, Rosskamp, Ralf, Blank, Melanie, Yang, Sixun, Fargue, Sonia, Rumsby, Gill, Groothoff, Jaap, Allain, Meaghan, West, Melissa, Hollander, Kim, Lowther, W Todd, Lieske, John C

“…Patients with primary hyperoxaluria experience kidney stones from a young age and can develop progressive oxalate nephropathy. Progression to kidney failure…”
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Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure by Booth, William T, Walker, Noah B, Lowther, W Todd, Howlett, Allyn C

“…Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB cannabinoid receptor-associated protein, first identified from a yeast two-hybrid…”
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Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria by Summitt, Candice B, Johnson, Lynnette C, Jönsson, Thomas J, Parsonage, Derek, Holmes, Ross P, Lowther, W Todd

“…The primary hyperoxalurias (PH), types 1-3, are disorders of glyoxylate metabolism that result in increased oxalate production and calcium oxalate stone…”
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Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3 by Li, Xingsheng, Knight, John, Todd Lowther, W., Holmes, Ross P.

“…Primary Hyperoxaluria Type 3 is a recently discovered form of this autosomal recessive disease that results from mutations in the gene coding for…”
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Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation by Poynton, Rebecca A, Peskin, Alexander V, Haynes, Alexina C, Lowther, W Todd, Hampton, Mark B, Winterbourn, Christine C

“…Mammalian 2-cysteine peroxiredoxins (Prxs) are susceptible to hyperoxidation by excess H2O2. The cytoplasmic family member Prx2 hyperoxidizes more readily than…”
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Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins by Cox, Andrew G, Pearson, Andree G, Pullar, Juliet M, Jönsson, Thomas J, Lowther, W Todd, Winterbourn, Christine C, Hampton, Mark B

“…The Prxs (peroxiredoxins) are a family of cysteine-dependent peroxidases that decompose hydrogen peroxide. Prxs become hyperoxidized when a sulfenic acid…”
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Molecular Basis for the Resistance of Human Mitochondrial 2-Cys Peroxiredoxin 3 to Hyperoxidation by Haynes, Alexina C., Qian, Jiang, Reisz, Julie A., Furdui, Cristina M., Lowther, W. Todd

“…Peroxiredoxins (Prxs) detoxify peroxides and modulate H2O2-mediated cell signaling in normal and numerous pathophysiological contexts. The typical 2-Cys…”
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Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat by Lowther, W Todd, Pemble, Charles W, Johnson, Lynnette C, Kridel, Steven J

“…Human fatty acid synthase (FAS) is uniquely expressed at high levels in many tumor types. Pharmacological inhibition of FAS therefore represents an important…”
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The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria by Buchalski, Brianna, Wood, Kyle D., Challa, Anil, Fargue, Sonia, Holmes, Ross P., Lowther, W. Todd, Knight, John

“…The major clinical manifestation of the Primary Hyperoxalurias (PH) is increased production of oxalate, as a consequence of genetic mutations that lead to…”
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Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace by Lowther, W. Todd, Jönsson, Thomas J, Johnson, Lynnette C

“…Typical 2-Cys peroxiredoxins (Prxs) have an important role in regulating hydrogen peroxide-mediated cell signalling. In this process, Prxs can become…”
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Cannabinoid receptor interacting protein 1a interacts with myristoylated Gαi N terminus via a unique gapped β-barrel structure by Booth, William T., Clodfelter, Jill E., Leone-Kabler, Sandra, Hughes, Erin K., Eldeeb, Khalil, Howlett, Allyn C., Lowther, W. Todd

“…Cannabinoid receptor interacting protein 1a (CRIP1a) modulates CB1 cannabinoid receptor G-protein coupling in part by altering the selectivity for Gαi subtype…”
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Giα and β Proteins Associate in a Complex with Cannabinoid Receptor Interacting Protein 1a (CRIP1a) by Hughes, Erin K., England, Andrew C., Leone‐Kabler, Sandra, Lowther, W. T., Howlett, Allyn C.

“…Cannabis usage in recent years has increased due to the legalization of both recreational and medical use. The CB1cannabinoid receptor (CB1R) is a G‐protein…”
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Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria by Riedel, Travis J, Johnson, Lynnette C, Knight, John, Hantgan, Roy R, Holmes, Ross P, Lowther, W Todd

“…4-hydroxy-2-oxoglutarate (HOG) aldolase is a unique enzyme in the hydroxyproline degradation pathway catalyzing the cleavage of HOG to pyruvate and glyoxylate…”
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Expression and purification of integral membrane fatty acid desaturases by Chen, Haiqin, Gu, Zhennan, Zhang, Hao, Wang, Mingxuan, Chen, Wei, Lowther, W Todd, Chen, Yong Q

“…Fatty acid desaturase enzymes perform dehydrogenation reactions leading to the insertion of double bonds in fatty acids, and are divided into soluble and…”
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Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma by Cunniff, Brian, Newick, Kheng, Nelson, Kimberly J, Wozniak, Alexandra N, Beuschel, Stacie, Leavitt, Bruce, Bhave, Anant, Butnor, Kelly, Koenig, Andreas, Chouchani, Edward T, James, Andrew M, Haynes, Alexina C, Lowther, W Todd, Murphy, Michael P, Shukla, Arti, Heintz, Nicholas H

“…Dysregulation of signaling pathways and energy metabolism in cancer cells enhances production of mitochondrial hydrogen peroxide that supports tumorigenesis…”
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