Search Results - "Lowther, Katie M."

Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice by Guzeloglu-Kayisli, Ozlem, Lalioti, Maria D, Aydiner, Fulya, Sasson, Isaac, Ilbay, Orkan, Sakkas, Denny, Lowther, Katie M, Mehlmann, Lisa M, Seli, Emre

“…Gene expression during oocyte maturation and early embryogenesis up to zygotic genome activation requires translational activation of maternally-derived mRNAs…”
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Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte—somatic communication by Lowther, Katie M, Favero, Federico, Yang, Cai-Rong, Taylor, Hugh S, Seli, Emre

“…Embryonic poly(A)-binding protein (EPAB)-deficient mice are infertile due to defects in both the oocyte and the somatic cells of the ovary. Since EPAB is…”
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Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice by Yang, Cai-Rong, Lowther, Katie M, Lalioti, Maria D, Seli, Emre

“…Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic…”
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Supplementing culture medium with the weak acid, 5,5-dimethyl-2,4-oxazolidinedione (DMO) limits the development of aneuploid mouse embryos through a Trp53-dependent mechanism by Lowther, Katie M., Bartolucci, Alison F., Massey, Rachael E., Brown, Judy, Peluso, John J.

“…Purpose This study was designed to determine if DMO limits in vitro development of aneuploid-enriched mouse embryos by activating a Trp53 -dependent mechanism…”
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Embryonic Poly(A)-Binding Protein Is Required During Early Stages of Mouse Oocyte Development for Chromatin Organization, Transcriptional Silencing, and Meiotic Competence1 by Lowther, Katie M, Mehlmann, Lisa M

“…During oocyte maturation, fertilization, and early embryo development until zygotic genome activation (ZGA), transcription is suppressed, and gene expression…”
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Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases by Egbert, Jeremy R, Uliasz, Tracy F, Lowther, Katie M, Kaback, Deborah, Wagner, Brandon M, Healy, Chastity L, O'Connell, Timothy D, Potter, Lincoln R, Jaffe, Laurinda A, Yee, Siu-Pok

“…The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and guanylyl cyclase B, have critical functions in many signaling pathways,…”
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Maturation, Fertilization, and the Structure and Function of the Endoplasmic Reticulum in Cryopreserved Mouse Oocytes by Lowther, Katie M, Weitzman, Vanessa N, Maier, Donald, Mehlmann, Lisa M

“…Oocyte cryopreservation is a promising technology that could benefit women undergoing assisted reproduction. Most studies examining the effects of…”
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Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells by Lowther, Katie M, Uliasz, Tracy F, Götz, Konrad R, Nikolaev, Viacheslav O, Mehlmann, Lisa M

“…G protein-coupled receptor 3 (GPR3) is a constitutively active receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels required for…”
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Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest by Lowther, Katie M, Nikolaev, Viacheslav O, Mehlmann, Lisa M

“…Mammalian oocytes are arrested at prophase I of meiosis until a preovulatory surge of LH stimulates them to resume meiosis. Prior to the LH surge, high levels…”
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Bone matrix osteonectin limits prostate cancer cell growth and survival by Kapinas, Kristina, Lowther, Katie M., Kessler, Catherine B., Tilbury, Karissa, Lieberman, Jay R., Tirnauer, Jennifer S., Campagnola, Paul, Delany, Anne M.

“…There is considerable interest in understanding prostate cancer metastasis to bone and the interaction of these cells with the bone microenvironment…”
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Puberty Suppression Followed by Testosterone Therapy Does Not Impair Reproductive Potential in Female Mice by Godiwala, Prachi, Uliasz, Tracy F, Lowther, Katie M, Kaback, Deborah, Mehlmann, Lisa M

“…Abstract More adolescents are coming out as transgender each year and are put on puberty blockers to suppress natal puberty, which is then followed by…”
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SNAP23 is required for constitutive and regulated exocytosis in mouse oocytes by Mehlmann, Lisa M, Uliasz, Tracy F, Lowther, Katie M

“…Mammalian oocytes are stored in the ovary for prolonged periods, and arrested in meiotic prophase. During this period, their plasma membranes are constantly…”
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Generation and Characterization of a TRIM21 Overexpressing Mouse Line by Mehlmann, Lisa M., Uliasz, Tracy F., Yee, Siu‐Pok, Kaback, Deborah, Lowther, Katie M.

“…Specific removal of a protein is a key to understanding its function. “Trim‐Away” utilizes TRIM21, an antibody receptor and ubiquitin ligase, for acute and…”
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Reorganization of the Endoplasmic Reticulum and Development of Ca2+ Release Mechanisms During Meiotic Maturation of Human Oocytes1 by Mann, Jessica S, Lowther, Katie M, Mehlmann, Lisa M

“…Oocyte maturation in rodents is characterized by a dramatic reorganization of the endoplasmic reticulum (ER) and an increase in the ability of an oocyte to…”
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Embryonic Poly(A)-Binding Protein Is Required During Early Stages of Mouse Oocyte Development for Chromatin Organization, Transcriptional Silencing, and Meiotic Competence by Lowther, Katie M, Mehlmann, Lisa M

“…During oocyte maturation, fertilization, and early embryo development until zygotic genome activation (ZGA), transcription is suppressed, and gene expression…”
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Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase by Egbert, Jeremy R., Silbern, Ivan, Uliasz, Tracy F., Lowther, Katie M., Yee, Siu-Pok, Urlaub, Henning, Jaffe, Laurinda A.

“…In response to luteinizing hormone (LH), multiple proteins in rat and mouse granulosa cells are rapidly dephosphorylated, but the responsible phosphatases…”
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Epab is dispensable for mouse spermatogenesis and male fertility by Ozturk, Saffet, Guzeloglu-Kayisli, Ozlem, Lowther, Katie M., Lalioti, Maria D., Sakkas, Denny, Seli, Emre

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Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles by Baena, Valentina, Owen, Corie M, Uliasz, Tracy F, Lowther, Katie M, Yee, Siu-Pok, Terasaki, Mark, Egbert, Jeremy R, Jaffe, Laurinda A

“…Abstract Meiotic arrest and resumption in mammalian oocytes are regulated by 2 opposing signaling proteins in the cells of the surrounding follicle: the…”
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Maturation, Fertilization, and the Structure and Function of the Endoplasmic Reticulum in Cryopreserved Mouse Oocytes1 by Lowther, Katie M, Weitzman, Vanessa N, Maier, Donald, Mehlmann, Lisa M

“…Oocyte cryopreservation is a promising technology that could benefit women undergoing assisted reproduction. Most studies examining the effects of…”
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Reorganization of the Endoplasmic Reticulum and Development of Ca²⁺ Release Mechanisms During Meiotic Maturation of Human Oocytes by Mann, Jessica S, Lowther, Katie M, Mehlmann, Lisa M

“…Oocyte maturation in rodents is characterized by a dramatic reorganization of the endoplasmic reticulum (ER) and an increase in the ability of an oocyte to…”
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