Search Results - "Lowry, John P."

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium by Kealy, John, Murray, Carol, Griffin, Eadaoin W, Lopez-Rodriguez, Ana Belen, Healy, Dáire, Tortorelli, Lucas Silva, Lowry, John P, Watne, Leiv Otto, Cunningham, Colm

“…Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and…”
Get full text

Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales by Teles-Grilo Ruivo, Leonor M., Baker, Keeley L., Conway, Michael W., Kinsley, Peter J., Gilmour, Gary, Phillips, Keith G., Isaac, John T.R., Lowry, John P., Mellor, Jack R.

“…Cholinergic neurotransmission throughout the neocortex and hippocampus regulates arousal, learning, and attention. However, owing to the poorly characterized…”
Get full text

Hyperthermia elevates brain temperature and improves behavioural signs in animal models of autism spectrum disorder by Lopez-Rodriguez, Ana Belen, Murray, Carol L, Kealy, John, Towns, Clodagh, Roche, Andrew, Nazmi, Arshed, Doran, Michelle, Lowry, John P, Cunningham, Colm

“…Autism spectrum disorders (ASD) are predominantly neurodevelopmental and largely genetically determined. However, there are human data supporting the idea that…”
Get full text

Development of an implantable d-serine biosensor for in vivo monitoring using mammalian d-amino acid oxidase on a poly ( o-phenylenediamine) and Nafion-modified platinum–iridium disk electrode by Zain, Zainiharyati M., O’Neill, Robert D., Lowry, John P., Pierce, Kenneth W., Tricklebank, Mark, Dewa, Aidiahmad, Ghani, Sulaiman Ab

“…d-serine has been implicated as a brain messenger, promoting not only neuronal signalling but also synaptic plasticity. Thus, a sensitive tool for d-serine…”
Get full text

Real-Time Monitoring of Brain Tissue Oxygen Using a Miniaturized Biotelemetric Device Implanted in Freely Moving Rats by Bazzu, Gianfranco, Puggioni, Giulia G. M, Dedola, Sonia, Calia, Giammario, Rocchitta, Gaia, Migheli, Rossana, Desole, Maria S, Lowry, John P, O’Neill, Robert D, Serra, Pier A

“…A miniaturized biotelemetric device for the amperometric detection of brain tissue oxygen is presented. The new system, derived from a previous design, has…”
Get full text

Biotelemetric monitoring of brain neurochemistry in conscious rats using microsensors and biosensors by Calia, Giammario, Rocchitta, Gaia, Migheli, Rossana, Puggioni, Giulia, Spissu, Ylenia, Bazzu, Gianfranco, Mazzarello, Vittorio, Lowry, John P, O'Neill, Robert D, Desole, Maria S, Serra, Pier A

“…In this study we present the real-time monitoring of three key brain neurochemical species in conscious rats using implantable amperometric electrodes…”
Get full text

The effect of NMDA-R antagonism on simultaneously acquired local field potentials and tissue oxygen levels in the brains of freely-moving rats by Kealy, John, Commins, Sean, Lowry, John P.

“…Non-competitive NMDA receptor antagonists are known to induce psychosis-like symptoms in rodents. Administration of such compounds cause behavioural effects…”
Get full text

Design optimisation and characterisation of an amperometric glutamate oxidase-based composite biosensor for neurotransmitter l-glutamic acid by Bermingham, Kobi P., Doran, Michelle M., Bolger, Fiachra B., Lowry, John P.

“…A polymer/enzyme composite biosensor for monitoring neurochemical glutamate was performance optimised in vitro for sensitivity, selectivity and stability. This…”
Get full text

Characterisation of a microelectrochemical biosensor for real-time detection of brain extracellular d-serine by Doran, Michelle M., Bermingham, Kobi P., Tricklebank, Mark D., Lowry, John P.

“…A modified development protocol and concomitant characterisation of a first generation biosensor for the detection of brain extracellular d-serine is reported…”
Get full text

Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring by Kirwan, Sarah M., Rocchitta, Gaia, McMahon, Colm P., Craig, Jennifer D., Killoran, Sarah J., O’Brien, Kylie B., Serra, Pier A., Lowry, John P., O’Neill, Robert D.

“…Reports that globular proteins could enhance the interference blocking ability ofthe PPD (poly(o-phenylenediamine) layer used as a permselective barrier in…”
Get full text

Characterization in vitro and in vivo of the oxygen dependence of an enzyme/polymer biosensor for monitoring brain glucose by Dixon, Blanaid M, Lowry, John P, O'Neill, Robert D

“…The oxygen dependence of a first generation amperometric biosensor was investigated in vitro and in vivo by monitoring its glucose response as a function of…”
Get full text

Brain Tissue Oxygen: In Vivo Monitoring with Carbon Paste Electrodes by Bolger, Fiachra B., Lowry, John P.

“…In this communication we review selected experiments involving the use ofcarbon paste electrodes (CPEs) to monitor and measure brain tissue O2 levels in…”
Get full text

Simultaneous recording of hippocampal oxygen and glucose in real time using constant potential amperometry in the freely-moving rat by Kealy, John, Bennett, Rachel, Lowry, John P.

“…► We show that average concentrations of hippocampal oxygen and glucose are 100.26±5.76μM and 0.60±0.06mM respectively. ► We show that there are uncoupled…”
Get full text

Development of a microelectrochemical biosensor for the real-time detection of choline by Baker, Keeley L., Bolger, Fiachra B., Lowry, John P.

“…•A first generation biosensor has been designed for the detection of choline.•Biosensor displays excellent sensitivity to choline.•Biosensor does not display…”
Get full text

A microelectrochemical biosensor for real-time in vivo monitoring of brain extracellular choline by Baker, Keeley L, Bolger, Fiachra B, Lowry, John P

“…A first generation Pt-based polymer enzyme composite biosensor developed for real-time neurochemical monitoring was characterised in vivo for sensitive and…”
Get more information

Real-time effects of insulin-induced hypoglycaemia on hippocampal glucose and oxygen by Kealy, John, Bennett, Rachel, Lowry, John P

“…Abstract The hippocampus plays a vital role in learning and memory and is susceptible to damage following hypoglycaemic shock. The effect of an acute…”
Get full text

Characterisation of a Platinum‐based Electrochemical Biosensor for Real‐time Neurochemical Analysis of Choline by Baker, Keeley L., Bolger, Fiachra B., Doran, Michelle M., Lowry, John P.

“…A choline biosensor was characterised in detail to determine the effects of physiologically relevant parameters on the ability of the sensor to reliably detect…”
Get full text

Real-time changes in hippocampal energy demands during a spatial working memory task by Kealy, John, Bennett, Rachel, Woods, Barbara, Lowry, John P.

“…Activity-dependent changes in hippocampal energy consumption have largely been determined using microdialysis. However, real-time recordings of brain energy…”
Get full text

An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements by Cloutier, Mathieu, Bolger, Fiachra B., Lowry, John P., Wellstead, Peter

“…An integrative, systems approach to the modelling of brain energy metabolism is presented. Mechanisms such as glutamate cycling between neurons and astrocytes…”
Get full text

Aversive prediction error signals in the amygdala by McHugh, Stephen B, Barkus, Christopher, Huber, Anna, Capitão, Liliana, Lima, João, Lowry, John P, Bannerman, David M

“…Prediction error signals are fundamental to learning. Here, in mice, we show that aversive prediction signals are found in the hemodynamic responses and theta…”
Get full text