Search Results - "Lowndes, HE"

Distribution and Induction of Cytochrome P450 1A1 and 1A2 in Rat Brain by Morse, Dennis C., Stein, Adam P., Thomas, Paul E., Lowndes, Herbert E.

“…Cytochromes P450 1A1 and 1A2 are involved in the oxidation of a wide spectrum of endogenous compounds and xenobiotics. Although their presence has been…”
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Constitutive and inducible levels of CYP1A1 and CYP1A2 in rat cerebral cortex and cerebellum by IBA, Michael M, STORCH, Amijoy, GHOSAL, Anima, BENNETT, Susan, REUHL, Kenneth R, LOWNDES, Herbert E

“…We examined the constitutive and inducible levels of microsomal cytochromes P450 1A1 and 1A2 (CYP1A) in rat cerebral cortex and cerebellum at the level of…”
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Methylmercury Alters Eph and Ephrin Expression During Neuronal Differentiation of P19 Embryonal Carcinoma Cells by Wilson, D.T., Polunas, M.A., Zhou, R., Halladay, A.K., Lowndes, H.E., Reuhl, K.R.

“…Developmental exposure to methylmercury (MeHg) induces a spectrum of neurological impairment characterized by cognitive disturbance, sensory/motor deficit, and…”
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Cellular and regional distribution of reduced glutathione in the nervous system of the rat: histochemical localization by mercury orange and o-phthaldialdehyde-induced histofluorescence by Philbert, M A, Beiswanger, C M, Waters, D K, Reuhl, K R, Lowndes, H E

“…Differences in the cellular distribution of antioxidant defense mechanisms in heterogeneous tissue such as the nervous system are likely critical determinants…”
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Glutathione S-transferases and gamma-glutamyl transpeptidase in the rat nervous systems: a basis for differential susceptibility to neurotoxicants by Philbert, M A, Beiswanger, C M, Manson, M M, Green, J A, Novak, R F, Primiano, T, Reuhl, K R, Lowndes, H E

“…Glutathione and its related enzymes play a major role in the detoxification of toxic chemicals. In rat brain the pattern of distribution of reduced glutathione…”
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Developmental changes in the cellular distribution of glutathione and glutathione S-transferases in the murine nervous system by Beiswanger, C M, Diegmann, M H, Novak, R F, Philbert, M A, Graessle, T L, Reuhl, K R, Lowndes, H E

“…The distribution of glutathione (GSH) and glutathione S-transferases (GSTs) in the adult rat brain is cell-type specific, but their cellular distribution in…”
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Substrates for neural metabolism of xenobiotics in adult and developing brain by Lowndes, H E, Beiswanger, C M, Philbert, M A, Reuhl, K R

“…Cellular heterogeneity and structural complexity of the nervous system, coupled with regional and cellular differences in the metabolic capabilities of…”
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The effect of glutathione depletion on methyl mercury-induced microtubule disassembly in cultured embryonal carcinoma cells by Graff, R D, Philbert, M A, Lowndes, H E, Reuhl, K R

“…Microtubule (MT) assembly and stability are thought to be dependent on intracellular glutathione for the maintenance of critical sulfhydryl groups. Since…”
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Early degeneration and sprouting at the rat neuromuscular junction following acrylamide administration by DeGrandchamp, R L, Lowndes, H E

“…Prolonged acrylamide administration produces motor nerve-terminal branch degeneration and impairs axonal outgrowth following nerve crush. It is unclear how…”
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Synaptic terminal degeneration and remodeling at the rat neuromuscular junction resulting from a single exposure to acrylamide by DeGrandchamp, R L, Reuhl, K R, Lowndes, H E

“…Repetitive exposure to low doses of acrylamide results in extensive pathological changes at the neuromuscular junction (NMJ), but it remains undetermined if a…”
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Synergistic neurotoxic effects of styrene oxide and acrylamide: glutathione-independent necrosis of cerebellar granule cells by Beiswanger, C M, Mandella, R D, Graessle, T R, Reuhl, K R, Lowndes, H E

“…Conjugation with glutathione (GSH) is a mechanism of detoxification of acrylamide (ACR); hence, prior depletion of GSH might be expected to exacerbate ACR's…”
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Effects of pargyline and pyrogallol on the methamphetamine-induced dopamine depletion by Kita, T, Wagner, G C, Philbert, M A, King, L A, Lowndes, H E

“…The formation of 6-hydroxydopamine (6-OHDA) from dopamine (DA) was investigated in the striatum of male Sprague-Dawley rats following a single administration…”
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Motor unit function during evolution of proximal axonal swellings by Delio, D A, Fiori, M G, Lowndes, H E

“…beta,beta'-Iminodipropionitrile (IDPN) impairs axonal transport of neurofilaments; their accumulation leads to the formation of proximal swellings in motor…”
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Ectopic impulse generation in dorsal root ganglion neurons during methylmercury intoxication: an electrophysiological and morphological study by Delio, D A, Reuhl, K R, Lowndes, H E

“…Electrophysiological function and morphology of dorsal root ganglion (DRG) neurons were investigated in female Wistar rats following administration of…”
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Electrophysiological correlates of sensorimotor system neurotoxicology by Baker, T, Lowndes, H E

“…In this review the authors consider the electrophysiological consequences of neuropathological changes induced by toxic chemicals in sensorimotor systems. A…”
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3-Acetylpyridine-induced degeneration in the dorsal root ganglia: involvement of small diameter neurons and influence of axotomy by Beiswanger, C M, Roscoe-Graessle, T L, Zerbe, N, Reuhl, K R, Lowndes, H E

“…3-Acetylpyridine (3-AP), an analogue of nicotinamide, produces highly selective CNS lesions, the severity of which may be influenced by prior alterations in…”
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Histochemical study of Sarcocystis sp. intramuscular cysts in gastrocnemius and soleus of the cat by Fiori, M G, Lowndes, H E

“…Histochemical investigations of Sarcocystis microcysts found in two hindleg muscles of cats were carried out. Genus identification was based on the reinforced…”
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Influence of proximal axonal swellings on rhythmic motoneuron firing by Delio, D A, Lowndes, H E

“…Previous studies of electrophysiological function of motoneurons (MNs) in animals with beta, beta'-iminodipropionitrile (IDPN) neuropathy revealed alterations…”
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Enhanced resolution of histochemical distribution of glucose-6- phosphate dehydrogenase activity in rat neural tissue by use of a semipermeable membrane by Philbert, MA, Beiswanger, CM, Roscoe, TL, Waters, DK, Lowndes, HE

“…We examined the histochemical distribution of glucose-6-phosphate dehydrogenase (G6PD) activity in neural tissue using different diffusion barriers. Although…”
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Prejunctional effects of vecuronium in the cat by BAKER, T, AGUERO, A, STANEC, A, LOWNDES, H. E

“…This study explored the prejunctional actions of vecuronium using the in vivo cat soleus nerve-muscle preparation. Vecuronium doses of 1 to 5 micrograms/kg iv…”
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