Search Results - "Lowes, Michelle A."

Immunology of Psoriasis by Lowes, Michelle A, Suárez-Fariñas, Mayte, Krueger, James G

“…The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-associated lymphoid…”
Get full text

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses by Lowes, Michelle A, Russell, Chris B, Martin, David A, Towne, Jennifer E, Krueger, James G

“…Psoriasis is a complex inflammatory process resulting from activation of the well-defined interleukin (IL)-23/T17 cytokine axis. We review the role of key…”
Get full text

Evaluating patients' unmet needs in hidradenitis suppurativa: Results from the Global Survey Of Impact and Healthcare Needs (VOICE) Project by Garg, Amit, Neuren, Erica, Cha, Denny, Kirby, Joslyn S., Ingram, John R., Jemec, Gregor B.E., Esmann, Solveig, Thorlacius, Linnea, Villumsen, Bente, Marmol, Véronique del, Nassif, Aude, Delage, Maia, Tzellos, Thrasyvoulos, Moseng, Dagfinn, Grimstad, Øystein, Naik, Haley, Micheletti, Robert, Guilbault, Sandra, Miller, Angie Parks, Hamzavi, Iltefat, van der Zee, Hessel, Prens, Errol, Kappe, Naomi, Ardon, Christine, Kirby, Brian, Hughes, Rosalind, Zouboulis, Christos C., Nikolakis, Georgios, Bechara, Falk G., Matusiak, Lukasz, Szepietowski, Jacek, Glowaczewska, Amelia, Smith, Saxon D., Goldfarb, Noah, Daveluy, Steven, Avgoustou, Christina, Giamarellos-Bourboulis, Evangelos, Cohen, Steven, Soliman, Yssra, Brant, Elena Gonzalez, Akilov, Oleg, Sayed, Christopher, Tan, Jerry, Alavi, Afsaneh, Lowes, Michelle A., Pascual, José Carlos, Riad, Hassan, Fisher, Shani, Cohen, Arnon, Paek, So Yeon, Resnik, Barry, Ju, Qiang, Wang, Lanqi, Strunk, Andrew

“…A needs assessment for patients with hidradenitis suppurativa (HS) will support advancements in multidisciplinary care, treatment, research, advocacy, and…”
Get full text

Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease by Tian, Suyan, Krueger, James G, Li, Katherine, Jabbari, Ali, Brodmerkel, Carrie, Lowes, Michelle A, Suárez-Fariñas, Mayte

“…The cause of psoriasis, a common chronic inflammatory skin disease, is not fully understood. Microarray experiments have been widely used in recent years to…”
Get full text

The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases by Harden, Jamie L., PhD, Lewis, Steven M, Lish, Samantha R, Suárez-Fariñas, Mayte, PhD, Gareau, Daniel, PhD, Lentini, Tim, MS, Johnson-Huang, Leanne M., PhD, Krueger, James G., MD, PhD, Lowes, Michelle A., MD, PhD

“…Background Many human diseases arise from or have pathogenic contributions from a dysregulated immune response. One pathway with immunomodulatory ability is…”
Get full text

Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature by Hoffman, Lauren K, Tomalin, Lewis E, Schultz, Gregory, Howell, Michael D, Anandasabapathy, Niroshana, Alavi, Afsaneh, Suárez-Fariñas, Mayte, Lowes, Michelle A

“…Hidradenitis suppurativa (HS) is a chronic skin disease of the pilo-sebaceous apocrine unit characterized by significant inflammation and an impaired quality…”
Get full text

Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis by Jordan, Catherine T., Cao, Li, Roberson, Elisha D.O., Duan, Shenghui, Helms, Cynthia A., Nair, Rajan P., Duffin, Kristina Callis, Stuart, Philip E., Goldgar, David, Hayashi, Genki, Olfson, Emily H., Feng, Bing-Jian, Pullinger, Clive R., Kane, John P., Wise, Carol A., Goldbach-Mansky, Raphaela, Lowes, Michelle A., Peddle, Lynette, Chandran, Vinod, Liao, Wilson, Rahman, Proton, Krueger, Gerald G., Gladman, Dafna, Elder, James T., Menter, Alan, Bowcock, Anne M.

“…Psoriasis is a common inflammatory disorder of the skin and other organs. We have determined that mutations in CARD14, encoding a nuclear factor of kappa light…”
Get full text

Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA) by Suárez-Fariñas, Mayte, Lowes, Michelle A, Zaba, Lisa C, Krueger, James G

“…Our objective was to develop a consistent molecular definition of psoriasis. There have been several published microarray studies of psoriasis, and we compared…”
Get full text

Worst area local Hidradenitis suppurativa Activity and Severity Index-Revised (W-HASI-R): a study evaluating construct validity by Bellefeuille, Gretchen, Paiewonsky, Briana, Khalid, Bisma, Freese, Rebecca L, Lowes, Michelle A, Kirby, Joslyn S, Alavi, Afsaneh, Goldfarb, Noah

“…Current validated hidradenitis suppurativa (HS) severity assessment tools are time-consuming and impractical in fast-paced, ambulatory clinic settings. This…”
Get full text

PSORS2 Is Due to Mutations in CARD14 by Jordan, Catherine T., Cao, Li, Roberson, Elisha D.O., Pierson, Katherine C., Yang, Chi-Fan, Joyce, Cailin E., Ryan, Caitriona, Duan, Shenghui, Helms, Cynthia A., Liu, Yin, Chen, Yongqing, McBride, Alison A., Hwu, Wuh-Liang, Wu, Jer-Yuarn, Chen, Yuan-Tsong, Menter, Alan, Goldbach-Mansky, Raphaela, Lowes, Michelle A., Bowcock, Anne M.

“…Psoriasis is a common, immune-mediated genetic disorder of the skin and is associated with arthritis in approximately 30% of cases. Previously, we localized…”
Get full text

IL-17 and TNF Synergistically Modulate Cytokine Expression while Suppressing Melanogenesis: Potential Relevance to Psoriasis by Wang, Claire Q.F., Akalu, Yemsratch T., Suarez-Farinas, Mayte, Gonzalez, Juana, Mitsui, Hiroshi, Lowes, Michelle A., Orlow, Seth J., Manga, Prashiela, Krueger, James G.

“…Inflammation-associated pigmentation changes are extremely common, but the etiology underlying this clinical observation remains elusive. Particularly, it is…”
Get full text

Psoriasis Is Characterized by Accumulation of Immunostimulatory and Th1/Th17 Cell-Polarizing Myeloid Dendritic Cells by Zaba, Lisa C., Fuentes-Duculan, Judilyn, Eungdamrong, Narat John, Abello, Maria Veronica, Novitskaya, Inna, Pierson, Katherine C., Gonzalez, Juana, Krueger, James G., Lowes, Michelle A.

“…Myeloid dermal dendritic cells (DCs) accumulate in chronically inflamed tissues such as psoriasis. The importance of these cells for psoriasis pathogenesis is…”
Get full text

A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis by Fuentes-Duculan, Judilyn, Suárez-Fariñas, Mayte, Zaba, Lisa C., Nograles, Kristine E., Pierson, Katherine C., Mitsui, Hiroshi, Pensabene, Cara A., Kzhyshkowska, Julia, Krueger, James G., Lowes, Michelle A.

“…Macrophages are important cells of the innate immune system, and their study is essential to gain greater understanding of the inflammatory nature of…”
Get full text

Innate immunity and microbial dysbiosis in hidradenitis suppurativa - vicious cycle of chronic inflammation by Chopra, Divya, Arens, Rachel A, Amornpairoj, Watcharee, Lowes, Michelle A, Tomic-Canic, Marjana, Strbo, Natasa, Lev-Tov, Hadar, Pastar, Irena

“…Hidradenitis Suppurativa (HS) is a chronic multifactorial inflammatory skin disease with incompletely understood mechanisms of disease pathology. HS is…”
Get full text

Low Expression of the IL-23/Th17 Pathway in Atopic Dermatitis Compared to Psoriasis by Guttman-Yassky, Emma, Lowes, Michelle A, Fuentes-Duculan, Judilyn, Zaba, Lisa C, Cardinale, Irma, Nograles, Kristine E, Khatcherian, Artemis, Novitskaya, Inna, Carucci, John A, Bergman, Reuven, Krueger, James G

“…The classical Th1/Th2 paradigm previously defining atopic dermatitis (AD) and psoriasis has recently been challenged with the discovery of Th17 T cells that…”
Get full text

Humanized anti–IFN-γ (HuZAF) in the treatment of psoriasis by Harden, Jamie L., PhD, Johnson-Huang, Leanne M., PhD, Chamian, Maria Francesca, MD, Lee, Edmund, MD, Pearce, Tillman, MD, Leonardi, Craig L., MD, Haider, Asifa, PhD, Lowes, Michelle A., MD, PhD, Krueger, James G., MD, PhD

Get full text

Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes by Zaba, Lisa C., MD, PhD, Suárez-Fariñas, Mayte, PhD, Fuentes-Duculan, Judilyn, MD, Nograles, Kristine E., MD, Guttman-Yassky, Emma, MD, MSc, Cardinale, Irma, MS, Lowes, Michelle A., MBBS, PhD, Krueger, James G., MD, PhD

“…Background TNF inhibitors have revolutionized the treatment of psoriasis vulgaris as well as psoriatic and rheumatoid arthritis and Crohn disease. Despite our…”
Get full text

CARD14 expression in dermal endothelial cells in psoriasis by Harden, Jamie L, Lewis, Steven M, Pierson, Katherine C, Suárez-Fariñas, Mayte, Lentini, Tim, Ortenzio, Francesca S, Zaba, Lisa C, Goldbach-Mansky, Raphaela, Bowcock, Anne M, Lowes, Michelle A

“…Mutations in the caspase recruitment domain, family member 14 (CARD14) gene have recently been described in psoriasis patients, and explain the psoriasis…”
Get full text

Effective Narrow-Band UVB Radiation Therapy Suppresses the IL-23/IL-17 Axis in Normalized Psoriasis Plaques by Johnson-Huang, Leanne M., Suárez-Fariñas, Mayte, Sullivan-Whalen, Mary, Gilleaudeau, Patricia, Krueger, James G., Lowes, Michelle A.

“…Narrow-band UVB radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of…”
Get full text

Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages by Zaba, Lisa C, Fuentes-Duculan, Judilyn, Steinman, Ralph M, Krueger, James G, Lowes, Michelle A

“…We used a panel of monoclonal antibodies to characterize DCs in the dermis of normal human skin. Staining for the CD11c integrin, which is abundant on many…”
Get full text