Search Results - "Lowery, Drew M"

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells by Burkard, Mark E, Maciejowski, John, Rodriguez-Bravo, Verónica, Repka, Michael, Lowery, Drew M, Clauser, Karl R, Zhang, Chao, Shokat, Kevan M, Carr, Steven A, Yaffe, Michael B, Jallepalli, Prasad V

“…Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small…”
Get full text

BRCT Repeats as Phosphopeptide-Binding Modules Involved in Protein Targeting by Manke, Isaac A., Lowery, Drew M., Nguyen, Anhco, Yaffe, Michael B.

“…We used a proteomic approach to identify phosphopeptide-binding modules mediating signal transduction events in the DNA damage response pathway. Using a…”
Get full text

Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate by Lowery, Drew M, Clauser, Karl R, Hjerrild, Majbrit, Lim, Dan, Alexander, Jes, Kishi, Kazuhiro, Ong, Shao-En, Gammeltoft, Steen, Carr, Steven A, Yaffe, Michael B

“…Polo‐like kinase‐1 (Plk1) phosphorylates a number of mitotic substrates, but the diversity of Plk1‐dependent processes suggests the existence of additional…”
Get full text

Natural-like function in artificial WW domains by Ranganathan, Rama, Russ, William P, Lowery, Drew M, Mishra, Prashant, Yaffe, Michael B

“…Protein sequences evolve through random mutagenesis with selection for optimal fitness. Cooperative folding into a stable tertiary structure is one aspect of…”
Get full text

Polo-Like Kinase Cdc5 Controls the Local Activation of Rho1 to Promote Cytokinesis by Yoshida, Satoshi, Kono, Keiko, Lowery, Drew M, Bartolini, Sara, Yaffe, Michael B, Ohya, Yoshikazu, Pellman, David

“…The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide…”
Get full text

The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry by Mazanka, Emily, Alexander, Jess, Yeh, Brian J, Charoenpong, Patrick, Lowery, Drew M, Yaffe, Michael, Weiss, Eric L

“…Cell fate can be determined by asymmetric segregation of gene expression regulators. In the budding yeast Saccharomyces cerevisiae, the transcription factor…”
Get full text

Structure and function of Polo-like kinases by LOWERY, Drew M, LIM, Daniel, YAFFE, Michael B

“…Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-like kinases contain an N-terminal Ser/Thr kinase catalytic…”
Get full text

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer by Yaffe, Michael B, Smerdon, Stephen J, Clapperton, Julie A, Manke, Isaac A, Lowery, Drew M, Ho, Timmy, Haire, Lesley F

“…Germline mutations in the BRCA1 tumor suppressor gene often result in a significant increase in susceptibility to breast and ovarian cancers. Although the…”
Get full text

Inhibition of TATA Binding Protein Dimerization by RNA Polymerase III Transcription Initiation Factor Brf1 by Alexander, Diane E, Kaczorowski, David J, Jackson-Fisher, Amy J, Lowery, Drew M, Zanton, Sara J, Pugh, B Franklin

“…The Brf1 subunit of TFIIIB plays an important role in recruiting the TATA-binding protein (TBP) to the up-stream region of genes transcribed by RNA polymerase…”
Get full text

A Coupled Chemical-Genetic and Bioinformatic Approach to Polo-like Kinase Pathway Exploration by Snead, Jennifer L., Sullivan, Matthew, Lowery, Drew M., Cohen, Michael S., Zhang, Chao, Randle, David H., Taunton, Jack, Yaffe, Michael B., Morgan, David O., Shokat, Kevan M.

“…Protein phosphorylation is a ubiquitous mechanism for cellular signal propagation, and signaling network complexity presents a challenge to protein kinase…”
Get full text

The Polo-Box Domain: A Molecular Integrator of Mitotic Kinase Cascades and Polo-like Kinase Function by Lowery, Drew M., Mohammad, Duaa H., Elia, Andrew E. H., Yaffe, Michael B.

“…No abstract yet available…”
Get full text

The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function by Lowery, Drew M, Mohammad, Duaa H, Elia, Andrew E H, Yaffe, Michael B

Get full text

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells: e1000111 by Burkard, Mark E, Maciejowski, John, Rodriguez-Bravo, Verónica, Repka, Michael, Lowery, Drew M, Clauser, Karl R, Zhang, Chao, Shokat, Kevan M, Carr, Steven A, Yaffe, Michael B, Jallepalli, Prasad V

“…Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small…”
Get full text

Polo-like kinase cdc5 controls the local activation of rhol to promote cytokinesis by YOSHIDA, Satoshi, KONO, Keiko, LOWERY, Drew M, BARTOLINI, Sara, YAFFE, Michael B, OHYA, Yoshikazu, PELLMAN, David

Get full text