Reduced metabolic complications in total parenteral nutrition: Pilot study using fat to replace one-third of glucose calories

A study assessed whether the addition of intravenous fat emulsion (Liposyn 10%) to provide 1/3rd of the total daily caloric requirements could reduce the metabolic complications of glucose-based total parenteral nutrition (TPN) relative to historic controls. The study was conducted for 14 days in 23...

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Bibliographic Details
Published in:	JPEN. Journal of parenteral and enteral nutrition Vol. 6; no. 4; pp. 304 - 307
Main Authors:	Meguid, Michael M, Schimmel, Elihu, Johnson, Willard C, Meguid, Victoria, Lowell, Barbara Cohen, Bourinski, James, Nabseth, Donald C
Format:	Journal Article
Language:	English
Published:	Thousand Oaks, CA Sage Publications 01-07-1982 SAGE Publications
Subjects:	Adult Aged Alkaline Phosphatase - blood clinical nutrition Defined-formula diets (DFD) diet Energy Intake Fat Emulsions, Intravenous - administration & dosage Food substitutions Glucose - administration & dosage Humans L-Lactate Dehydrogenase - blood Liver - metabolism Male Middle Aged Parenteral Nutrition - methods Parenteral Nutrition, Total - adverse effects Parenteral Nutrition, Total - methods patient care Pilot Projects Serum Albumin - analysis total parenteral nutrition
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Summary:	A study assessed whether the addition of intravenous fat emulsion (Liposyn 10%) to provide 1/3rd of the total daily caloric requirements could reduce the metabolic complications of glucose-based total parenteral nutrition (TPN) relative to historic controls. The study was conducted for 14 days in 23 critically-ill males (ages 28-76) requiring TPN. Serum osmolality, body weight, and serum albumin remained constant; glycosuria occurred in 15% of the subjects. Adverse side effects did not occur. The results indicated that fat substitution reduced glucose and hepatic-related metabolic complications. (wz)
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0148-6071 1941-2444
DOI:	10.1177/0148607182006004304