Search Results - "Lowe, S. W."

AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma by Xu, M Z, Chan, S W, Liu, A M, Wong, K F, Fan, S T, Chen, J, Poon, R T, Zender, L, Lowe, S W, Hong, W, Luk, J M

“…Yes-associated protein (YAP) is a downstream effector of the Hippo signaling pathway, which controls organ expansion and tissue development. We have recently…”
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The p53-Bcl-2 connection by Hemann, M T, Lowe, S W

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Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition by Soengas, M. S., Alarcón, R. M., Yoshida, H., Giaccia, A. J., Hakem, R., Mak, T. W., Lowe, S. W.

“…The ability of p53 to promote apoptosis in response to mitogenic oncogenes appears to be critical for its tumor suppressor function. Caspase-9 and its cofactor…”
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Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma by Lindemann, R.K, Newbold, A, Whitecross, K.F, Cluse, L.A, Frew, A.J, Ellis, L, Williams, S, Wiegmans, A.P, Dear, A.E, Scott, C.L, Pellegrini, M, Wei, A, Richon, V.M, Marks, Paul A, Lowe, S.W, Smyth, M.J, Johnstone, R.W

“…Histone deacetylase inhibitors (HDACi) can elicit a range of biological responses that affect tumor growth and survival, including inhibition of cell cycle…”
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Apoptosis in cancer by Lowe, Scott W., Lin, Athena W.

“…In the last decade, basic cancer research has produced remarkable advances in our understanding of cancer biology and cancer genetics. Among the most important…”
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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53 by Schmitt, C A, McCurrach, M E, de Stanchina, E, Wallace-Brodeur, R R, Lowe, S W

“…The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor…”
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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes by Woo, M, Hakem, R, Soengas, M S, Duncan, G S, Shahinian, A, Kägi, D, Hakem, A, McCurrach, M, Khoo, W, Kaufman, S A, Senaldi, G, Howard, T, Lowe, S W, Mak, T W

“…Caspases are fundamental components of the mammalian apoptotic machinery, but the precise contribution of individual caspases is controversial. CPP32 (caspase…”
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Clinical implications of p53 mutations by Wallace-Brodeur, R. R, Lowe, S. W

“…The ultimate goal of basic cancer research is to provide a theoretical foundation for rational approaches to improve cancer therapy. Our extensive insight into…”
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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis by LOWE, S. W, RULEY, H. E

“…Oncogenic transformation by human adenoviruses requires early regions 1A and 1B (E1A and E1B) and provides a model of multistep carcinogenesis. This study…”
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Granule exocytosis mediates immune surveillance of senescent cells by Sagiv, A, Biran, A, Yon, M, Simon, J, Lowe, S W, Krizhanovsky, V

“…Senescence is a stable cell cycle arrest program that contributes to tumor suppression, organismal aging and certain wound healing responses. During liver…”
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Tumor suppressive functions of p53 by Zilfou, Jack T, Lowe, Scott W

“…The majority of human cancers acquire mutations that abrogate the p53 tumor suppressor network and, as a consequence, p53 is one of the most extensively…”
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Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor β chain and KIT V654A by Spector, M S, Iossifov, I, Kritharis, A, He, C, Kolitz, J E, Lowe, S W, Allen, S L

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Activation of p53 by oncogenes by Lowe, S W

“…p53 is activated by a variety of cellular stresses, including DNA damage, hypoxia, and mitogenic oncogenes, but the extent to which each signal engages p53 as…”
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Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation by Koumenis, Constantinos, Alarcon, Rodolfo, Hammond, Ester, Sutphin, Patrick, Hoffman, William, Murphy, Maureen, Derr, Jennifer, Taya, Yoichi, Lowe, Scott W., Kastan, Michael, Giaccia, Amato

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours by Graeber, Thomas G, Osmanian, Cynthia, Jacks, Tyler, Housman, David E, Koch, Cameron J, Lowe, Scott W, Giaccia, Amato J

“…Apoptosis is a genetically encoded programme of cell death that can be activated under physiological conditions and may be an important safeguard against…”
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p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing by FLINTERMAN, M. B, MYMRYK, J. S, KLANRIT, P, YOUSEF, A. F, LOWE, S. W, CALDAS, C, GÄKEN, J, FARZANEH, F, TAVASSOLI, M

“…We have recently shown that E1A protein of human adenovirus downregulates epidermal growth factor receptor (EGFR) expression and induces apoptosis in head and…”
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FADD: Essential for Embryo Development and Signaling from Some, but Not All, Inducers of Apoptosis by Yeh, Wen-Chen, de la Pompa, José Luis, McCurrach, Mila E., Shu, Hong-Bing, Elia, Andrew J., Shahinian, Arda, Ng, Michelle, Wakeham, Andrew, Khoo, Wilson, Mitchell, Kyran, El-Deiry, Wafik S., Lowe, Scott W., Goeddel, David V.

“…FADD (also known as Mort-1) is a signal transducer downstream of cell death receptor CD95 (also called Fas). CD95, tumor necrosis factor receptor type 1…”
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An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo by Hannon, Gregory J, Lowe, Scott W, Hemann, Michael T, Fridman, Jordan S, Zilfou, Jack T, Hernando, Eva, Paddison, Patrick J, Cordon-Cardo, Carlos

“…The application of RNA interference (RNAi) to mammalian systems has the potential to revolutionize genetics and produce novel therapies. Here we investigate…”
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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents by Lowe, S W, Ruley, H E, Jacks, T, Housman, D E

“…Although the primary cellular targets of many anticancer agents have been identified, less is known about the processes leading to the selective cell death of…”
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p53 Status and the Efficacy of Cancer Therapy in Vivo by Lowe, Scott W., Bodis, Stephan, McClatchey, Andrea, Remington, Lee, Ruley, H. Earl, Fisher, David E., Housman, David E., Jacks, Tyler

“…The therapeutic responsiveness of genetically defined tumors expressing or devoid of the p53 tumor suppressor gene was compared in immunocompromised mice…”
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