Search Results - "Lowe, P J"

Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects by Arm, J. P., Bottoli, I., Skerjanec, A., Floch, D., Groenewegen, A., Maahs, S., Owen, C. E., Jones, I., Lowe, P. J.

“…Summary Background Using a monoclonal antibody with greater affinity for IgE than omalizumab, we examined whether more complete suppression of IgE provided…”
Get full text

Applying Physiological and Biochemical Concepts to Optimize Biological Drug Development by Lowe, PJ

“…Posology—the science of dose and regimen—is a critical part of drug development. It is concerned with ensuring that patients experience significant clinical…”
Get full text

Visualization and Communication of Pharmacometric Models With Berkeley Madonna by Krause, A, Lowe, PJ

“…Population or other pharmacometric models are a useful means to describe, succinctly, the relationships between drug administration, exposure (concentration),…”
Get full text

Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys by Dudal, S, Subramanian, K, Flandre, T, Law, WS, Lowe, PJ, Skerjanec, A, Genin, J-C, Duval, M, Piequet, A, Cordier, A, Jarai, G, Van Heeke, G, Taplin, S, Krantz, C, Jones, S, Warren, AP, Brennan, FR, Sims, J, Lloyd, P

“…QBP359 is an IgG1 human monoclonal antibody that binds with high affinity to human CCL21, a chemokine hypothesized to play a role in inflammatory disease…”
Get full text

Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy by Stuckey, D. J., Anthony, D. C., Lowe, J. P., Miller, J., Palm, W. M., Styles, P., Perry, V. H., Blamire, A. M., Sibson, N. R.

“…Macrophages are key components of the inflammatory response to tissue injury, but their activities can exacerbate neuropathology. High‐resolution magnetic…”
Get full text

On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development by Lowe, P. J., Hijazi, Y., Luttringer, O., Yin, H., Sarangapani, R., Howard, D.

“…The drug development process is divided into phases with decisions required on compound selection and promotion to each subsequent development phase. In…”
Get full text

Quantitative Pharmacology: An introduction to integrative pharmacokinetic‐pharmacodynamic analysis by Lowe, PJ

“…In “Quantitative Pharmacology,” Gabrielsson and Hjorth explain that it is the integration of key time‐dependent processes in vivo: pharmacokinetics (PK;…”
Get full text

Bridging Clinical Outcomes of Canakinumab Treatment in Patients With Rheumatoid Arthritis With a Population Model of IL‐1β Kinetics by Ait‐Oudhia, S, Lowe, PJ, Mager, DE

“…Canakinumab, an anti‐interleukin‐1β (IL‐1β) monoclonal antibody, is approved for cryopyrin‐associated periodic syndromes and is under investigation for the…”
Get full text

MRS reveals additional hexose N-acetyl resonances in the brain of a mouse model for Sandhoff disease by Lowe, J. P., Stuckey, D. J., Awan, F. R., Jeyakumar, M., Neville, D. C. A., Platt, F. M., Griffin, J. L., Styles, P., Blamire, A. M., Sibson, N. R.

“…Sandhoff disease, one of several related lysosomal storage disorders, results from the build up of N‐acetyl‐containing glycosphingolipids in the brain and is…”
Get full text

The accuracy evaluation of NIST-7 by Lee, W.D., Shirley, J.H., Lowe, J.P., Drullinger, R.E.

“…We have performed evaluations of the major systematic errors in NIST-7 with an overall uncertainty of less than a part in 10/sup 14/. The complete evaluation…”
Get full text

Evaluation of serum inhibin A as a surveillance marker after conservative management of tubal pregnancy by D'Antona, D, Mamers, P M, Lowe, P J, Balazs, N, Groome, N P, Wallace, E M

“…Tubal pregnancy is now commonly managed by laparoscopic salpingostomy or systemic methotrexate. A disadvantage of such conservative management is the need for…”
Get full text

Hormonal regulation of hepatocyte tight junctional permeability by Lowe, P J, Miyai, K, Steinbach, J H, Hardison, W G

“…We have investigated the effects of hormones on the permeability of the hepatocyte tight junction to two probes, [14C]sucrose and horseradish peroxidase, using…”
Get full text

Beach-Profile Measurement, Theory and Analysis: Practical Guidance and Applied Case Studies by Cooper, N. J., Leggett, D. J., Lowe, J. P.

“…Whilst beach‐profile surveying is a relatively long‐established and widely utilised shoreline monitoring technique, a considerable gap exists between…”
Get full text

The effects of colchicine on secretion into bile of bile salts, phospholipids, cholesterol and plasma membrane enzymes: bile salts are secreted unaccompanied by phospholipids and cholesterol by Barnwell, S G, Lowe, P J, Coleman, R

“…Colchicine, a drug which interferes with microtubular function, has no effect on the secretion of taurodehydrocholate into bile; it is therefore suggested that…”
Get full text

Error analysis of the NIST optically pumped primary frequency standard by Drullinger, R.E., Shirley, J.H., Lowe, J.P., Glaze, D.J.

“…The major sources of systematic error in the NIST optically pumped primary frequency standard has been evaluated with an uncertainty of a few parts in 10/sup…”
Get full text

Rapid kinetic analysis of the bile-salt-dependent secretion of phospholipid, cholesterol and a plasma-membrane enzyme into bile by Lowe, P J, Barnwell, S G, Coleman, R

“…Isolated rat livers were perfused under 'one-pass' conditions and bile was collected at 1 min intervals. After 1 min pulse, taurocholate appeared in the…”
Get full text

Transcytosis and paracellular movements of horseradish peroxidase across liver parenchymal tissue from blood to bile. Effects of alpha-naphthylisothiocyanate and colchicine by Lowe, P J, Kan, K S, Barnwell, S G, Sharma, R K, Coleman, R

“…The pathways for the entry of horseradish peroxidase (HRP) into bile have been investigated using the isolated perfused rat liver operating under one-pass…”
Get full text

Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats by Lowe, P J, Temple, C S

“…One of the major limiting steps for the absorption of peptide drugs from the intestine is proteolytic degradation. To slow this degradation, human calcitonin…”
Get more information

Evaluation of a malarial antibody assay for use in the screening of blood and tissue products for clinical use by Kitchen, A. D., Lowe, P. H. J, Lalloo, K., Chiodini, P. L.

“…Background and Objectives  A new recombinant Plasmodium antigen enzyme immunoassay (EIA) for the detection of malarial antibodies was evaluated for the…”
Get full text

Function of rat hepatocyte tight junctions: studies with bile acid infusions by Hardison, W G, Dalle-Molle, E, Gosink, E, Lowe, P J, Steinbach, J H, Yamaguchi, Y

“…To determine the effects of alteration of biliary paracellular permeability on bile flow and composition, we measured the biliary outputs of compounds highly…”
Get full text