Search Results - "Lowe, M. D."

Interaction of ocean acidification and temperature; the high cost of survival in the brittlestar Ophiura ophiura by Wood, Hannah L, Spicer, J. I, Lowe, D. M, Widdicombe, S

“…This study has demonstrated an interaction between the effect of increased ocean acidity and temperature (40 days exposure) on a number of key physiological…”
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High-Density Substrate Mapping in Brugada Syndrome: Combined Role of Conduction and Repolarization Heterogeneities in Arrhythmogenesis by LAMBIASE, P. D, AHMED, A. K, CIACCIO, E. J, BRUGADA, R, LIZOTTE, E, CHAUBEY, S, BEN-SIMON, Ron, CHOW, A. W, LOWE, M. D, MCKENNA, W. J

“…Two principal mechanisms are thought to be responsible for Brugada syndrome (BS): (1) right ventricular (RV) conduction delay and (2) RV subepicardial action…”
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Anti-oxidative hormetic effects of cellular autophagy induced by nutrient deprivation in a molluscan animal model by Moore, M.N., Shaw, J.P., Pascoe, C., Beesley, A., Viarengo, A., Lowe, D.M.

“…This investigation using a molluscan animal model tested the hypothesis that experimentally induced lysosomal autophagy protects against oxidative cell injury…”
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Safety and efficacy of multipolar pulmonary vein ablation catheter vs. irrigated radiofrequency ablation for paroxysmal atrial fibrillation: a randomized multicentre trial by McCready, J, Chow, A W, Lowe, M D, Segal, O R, Ahsan, S, de Bono, J, Dhaliwal, M, Mfuko, C, Ng, A, Rowland, E R, Bradley, R J W, Paisey, J, Roberts, P, Morgan, J M, Sandilands, A, Yue, A, Lambiase, P D

“…The current challenge in atrial fibrillation (AF) treatment is to develop effective, efficient, and safe ablation strategies. This randomized controlled trial…”
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Ocean warming and acidification; implications for the Arctic brittlestar Ophiocten sericeum by Wood, Hannah L., Spicer, J. I., Kendall, M. A., Lowe, D. M., Widdicombe, S.

“…The Arctic Ocean currently has the highest global average pH. However, due to increasing atmospheric CO 2 levels, it will become a region with one of the…”
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Activating PI3K[delta] mutations in a cohort of 669 patients with primary immunodeficiency by Elgizouli, M, Lowe, D M, Speckmann, C, Schubert, D, Hulsdunker, J, Eskandarian, Z, Dudek, A, Schmitt-Graeff, A, Wanders, J, Jorgensen, S F, Fevang, B, Salzer, U, Nieters, A, Burns, S, Grimbacher, B

“…Summary The gene PIK3CD codes for the catalytic subunit of phosphoinositide 3-kinase [delta] (PI3K[delta]), and is expressed solely in leucocytes. Activating…”
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Activating PI3Kδ mutations in a cohort of 669 patients with primary immunodeficiency by Elgizouli, M., Lowe, D. M., Speckmann, C., Schubert, D., Hülsdünker, J., Eskandarian, Z., Dudek, A., Schmitt‐Graeff, A., Wanders, J., Jørgensen, S. F., Fevang, B., Salzer, U., Nieters, A., Burns, S., Grimbacher, B.

“…Summary The gene PIK3CD codes for the catalytic subunit of phosphoinositide 3‐kinase δ (PI3Kδ), and is expressed solely in leucocytes. Activating mutations of…”
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Oxidative stress, lysosomal damage and dysfunctional autophagy in molluscan hepatopancreas (digestive gland) induced by chemical contaminants by Shaw, J.P., Moore, M.N., Readman, J.W., Mou, Z., Langston, W.J., Lowe, D.M., Frickers, P.E., Al-Moosawi, L., Pascoe, C., Beesley, A.

“…Autophagy is a highly conserved evolutionary survival or defence process that enables cells and organisms to survive periods of environmental stress by…”
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Pathological reactions and recovery of hepatopancreatic digestive cells from the marine snail Littorina littorea following exposure to a polycyclic aromatic hydrocarbon by Lowe, D.M., Moore, M.N., Readman, J.W.

“…The aim of this study was to investigate the cellular pathological responses of hepatopancreatic digestive cells from the periwinkle Littorina littorea exposed…”
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The influence of environmental contaminants on lysosomal activity in the digestive cells of mussels ( Mytilus galloprovincialis) from the Venice Lagoon by Lowe, D.M, Fossato, V.U

“…Lysosomes are subcellular organelles bounded by a semipermeable lipoprotein membrane that contain a battery of hydrolytic enzymes that are collectively capable…”
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Lysosomal membrane responses in the blood and digestive cells of mussels experimentally exposed to fluoranthene by Lowe, D.M., Soverchia, C., Moore, M.N.

“…In order to determine if cellular responses to contaminant exposure differed between cell types, from within the same host, neutral red retention (NRR) was…”
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Emergent synergistic lysosomal toxicity of chemical mixtures in molluscan blood cells (hemocytes) by Moore, M.N., Wedderburn, R.J., Clarke, K.R., McFadzen, I.R.B., Lowe, D.M., Readman, J.W.

“…The problem of effective assessment of risk posed by complex mixtures of toxic chemicals in the environment is a major challenge for government regulators and…”
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Contaminant-induced lysosomal membrane damage in blood cells of mussels Mytilus galloprovincialis from the Venice Lagoon: an in vitro study by Lowe, David M., Fossato, Valentino U., Depledge, Michael H.

“…Damage to blood cell lysosomes was investigated in vitro in mussels Mytilus galloprovincialis collected from a series of sites in the Lagoon of Venice, Italy,…”
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Invasive dermatophyte infection with Trichophyton interdigitale is associated with prurigo‐induced pseudoperforation and a signal transducer and activator of transcription 3 mutation by Simpson, J.K., Fröbel, P., Seneviratne, S.L., Brown, M., Lowe, D.M., Grimbacher, B., Fliegauf, M., Fearfield, L.

“…Summary Invasive dermatophyte infection, with extension beyond the dermis, in immunocompetent hosts is exceptionally rare. Dermatophytes are keratinophilic and…”
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Assessment of a conduction-repolarisation metric to predict Arrhythmogenesis in right ventricular disorders by Martin, C.A., Orini, M., Srinivasan, N.T., Bhar-Amato, J., Honarbakhsh, S., Chow, A.W., Lowe, M.D., Ben-Simon, R., Elliott, P.M., Taggart, P., Lambiase, P.D.

“…The re-entry vulnerability index (RVI) is a recently proposed activation-repolarization metric designed to quantify tissue susceptibility to re-entry. This…”
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Predictors of recurrence following radiofrequency ablation for persistent atrial fibrillation by McCready, James W, Smedley, Tom, Lambiase, Pier D, Ahsan, Syed Y, Segal, Oliver R, Rowland, Edward, Lowe, Martin D, Chow, Anthony W

“…To establish clinical factors affecting success in persistent atrial fibrillation (AF) ablation. Wide area circumferential ablation with linear and…”
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Stability of supported metal and supported metal oxide combustion catalysts by McCarty, Jon G., Gusman, M., Lowe, D.M., Hildenbrand, D.L., Lau, K.N.

“…Catalysts used for high-temperature combustion of light hydrocarbons must maintain high activity over long time intervals by avoiding excessive sintering and…”
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Impact of the Sea Empress oil spill on lysosomal stability in mussel blood cells by Fernley, P.W, Moore, M.N, Lowe, D.M, Donkin, P, Evans, S

“…Coastal zones are among the most productive and vulnerable areas on the planet. An example of impact on these fragile environments was shown in the case of the…”
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Incidence of left atrial thrombus prior to atrial fibrillation ablation: is pre-procedural transoesophageal echocardiography mandatory? by McCready, James W, Nunn, Laurence, Lambiase, Pier D, Ahsan, Syed Y, Segal, Oliver R, Rowland, Edward, Lowe, Martin D, Chow, Anthony W

“…The exact role of transoesphageal echo (TOE) prior to atrial fibrillation (AF) ablation remains unclear. This study examines the incidence and predictors of…”
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Outcome of ACHD patients with non-inducible versus inducible IART undergoing cavo-tricuspid isthmus ablation: the role of empiric ablation by Sawhney, V., Mc Lellan, A., Chatha, S., Perera, D., Aderonke, A., Juno, S., Whittaker-Axon, S., Daw, H., Garcia, J., Lambiase, P. D., Cullen, S., Bhan, A., Von Klemperer, K., Walker, F., Pandya, B., Lowe, M. D., Ezzat, V.

“…Purpose Catheter ablation for supraventricular tachycardia (SVT) in adults with congenital heart disease (ACHD) is an important therapeutic option…”
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