Search Results - "Low, Lawrence"

Axon pruning: an essential step underlying the developmental plasticity of neuronal connections by Low, Lawrence K, Cheng, Hwai-Jong

“…Regressive events play a key role in modifying neural connectivity in early development. An important regressive event is the pruning of neuronal processes…”
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Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex by Low, Lawrence K, Liu, Xiao-Bo, Faulkner, Regina L, Coble, Jeffrey, Cheng, Hwai-Jong

“…Neurons in the developing CNS tend to send out long axon collaterals to multiple target areas. For these neurons to attain specific connections, some of their…”
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Severe enterocolitis associated with antiepileptic-induced drug reaction with eosinophilia and systemic symptoms by Swanson, Eric A., MD, Low, Lawrence, MD, PhD, Naini, Bita V., MD

“…Summary Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious drug-induced reaction with cutaneous, hematologic, and solid-organ…”
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Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling by Faulkner, Regina L, Low, Lawrence K, Liu, Xiao-Bo, Coble, Jeffrey, Jones, Edward G, Cheng, Hwai-Jong

“…The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway. Several…”
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Stereotyped Axon Pruning via Plexin Signaling Is Associated with Synaptic Complex Elimination in the Hippocampus by Liu, Xiao-Bo, Low, Lawrence K, Jones, Edward G, Cheng, Hwai-Jong

“…Plexin signaling is required for stereotyped pruning of long axon collaterals in the vertebrate CNS; however, a cellular basis for plexins on stereotyped…”
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B-cell Lymphoproliferative Disorders Associated with Primary and Acquired Immunodeficiency by Low, Lawrence K., MD, PhD, Song, Joo Y., MD

“…Abstract The diagnosis of lymphoproliferative disorders associated with immunodeficiency can be challenging because many of these conditions have overlapping…”
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TIMES-SS—A promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity by Patlewicz, Grace, Dimitrov, Sabcho D., Low, Lawrence K., Kern, Petra S., Dimitrova, Gergana D., Comber, Mike I.H., Aptula, Aynur O., Phillips, Richard D., Niemelä, Jay, Madsen, Charlotte, Wedebye, Eva B., Roberts, David W., Bailey, Paul T., Mekenyan, Ovanes G.

“…The TImes MEtabolism Simulator platform used for predicting Skin Sensitization (TIMES-SS) is a hybrid expert system that was developed at Bourgas University…”
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A little nip and tuck: axon refinement during development and axonal injury by Low, Lawrence K, Cheng, Hwai-Jong

“…While building the nervous system, regions of some developing axons are eliminated; this can also happen as a result of axonal injury. During development, many…”
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TIMES-SS—A Mechanistic Evaluation of an External Validation Study Using Reaction Chemistry Principles by Roberts, David W, Patlewicz, Grace, Dimitrov, Sabcho D, Low, Lawrence K, Aptula, Aynur O, Kern, Petra S, Dimitrova, Gergana D, Comber, Mike I. H, Phillips, Richard D, Niemelä, Jay, Madsen, Charlotte, Wedebye, Eva B, Bailey, Paul T, Mekenyan, Ovanes G

“…The TImes MEtabolism Simulator platform used for predicting skin sensitization (TIMES-SS) is a hybrid expert system that was developed at Bourgas University…”
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Axon pruning in the developing vertebrate hippocampus by Faulkner, Regina L, Low, Lawrence K, Cheng, Hwai-Jong

“…During early development of the central nervous system (CNS), there is an exuberant outgrowth of projections which later need to be refined to achieve precise…”
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Skin Sensitization: Modeling Based on Skin Metabolism Simulation and Formation of Protein Conjugates by Dimitrov, Sabcho D., Low, Lawrence K., Patlewicz, Grace Y., Kern, Petra S., Dimitrova, Gergana D., Comber, Mike H. I., Phillips, Richard D., Niemela, Jay, Bailey, Paul T., Mekenyan, Ovanes G.

“…A quantitative structure-activity relationship (QSAR) system for estimating skin sensitization potency has been developed that incorporates skin metabolism and…”
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The Genetic Basis of Hepatosplenic T-cell Lymphoma by McKinney, Matthew, Moffitt, Andrea B, Gaulard, Philippe, Travert, Marion, De Leval, Laurence, Nicolae, Alina, Raffeld, Mark, Jaffe, Elaine S, Pittaluga, Stefania, Xi, Liqiang, Heavican, Tayla, Iqbal, Javeed, Belhadj, Karim, Delfau-Larue, Marie Helene, Fataccioli, Virginie, Czader, Magdalena B, Lossos, Izidore S, Chapman-Fredricks, Jennifer R, Richards, Kristy L, Fedoriw, Yuri, Ondrejka, Sarah L, Hsi, Eric D, Low, Lawrence, Weisenburger, Dennis, Chan, Wing C, Mehta-Shah, Neha, Horwitz, Steven, Bernal-Mizrachi, Leon, Flowers, Christopher R, Beaven, Anne W, Parihar, Mayur, Baseggio, Lucile, Parrens, Marie, Moreau, Anne, Sujobert, Pierre, Pilichowska, Monika, Evens, Andrew M, Chadburn, Amy, Au-Yeung, Rex K H, Srivastava, Gopesh, Choi, William W L, Goodlad, John R, Aurer, Igor, Basic-Kinda, Sandra, Gascoyne, Randy D, Davis, Nicholas S, Li, Guojie, Zhang, Jenny, Rajagopalan, Deepthi, Reddy, Anupama, Love, Cassandra, Levy, Shawn, Zhuang, Yuan, Datta, Jyotishka, Dunson, David B, Davé, Sandeep S

“…Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole-exome sequencing of 68…”
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Acceleration of oxidative folding of bovine pancreatic ribonuclease A by anion-induced stabilization and formation of structured native-like intermediates by Low, Lawrence K, Shin, Hang-Cheol, Narayan, Mahesh, Wedemeyer, William J, Scheraga, Harold A

“…Phosphate anions accelerate the oxidative folding of reduced bovine pancreatic ribonuclease A with dithiothreitol at several temperatures and ionic strengths…”
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De novo congenital melanoma: analysis of 2 cases with array comparative genomic hybridization by Su, Albert, Low, Lawrence, Li, Xinmin, Zhou, Shengmei, Mascarenhas, Leo, Barnhill, Raymond L

“…Congenital melanoma is extraordinarily rare, and 3 types have been described: transplacental metastases from the mother, de novo congenital melanoma, and…”
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Oxidative folding of bovine pancreatic ribonuclease A: insight into the overall catalysis of the refolding pathway by phosphate by Low, Lawrence K, Shin, Hang-Cheol, Scheraga, Harold A

“…The effects of the strong stabilizing anion, phosphate, on the oxidative folding of bovine pancreatic ribonuclease A were examined. Phosphate was found to…”
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The warfarin-sulfinpyrazone interaction: stereochemical considerations by Toon, S, Low, L K, Gibaldi, M, Trager, W F, O'Reilly, R A, Motley, C H, Goulart, D A

“…To allow the simultaneous evaluation of the interaction between sulfinpyrazone and each enantiomer of racemic warfarin, pseudoracemic warfarin (1:1 12C-R(+)…”
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Isolation and expression of a cDNA encoding the precursor for a novel member (ACADSB) of the acyl-CoA dehydrogenase gene family by Rozen, R, Vockley, J, Zhou, L, Milos, R, Willard, J, Fu, K, Vicanek, C, Low-Nang, L, Torban, E, Fournier, B

“…The acyl-CoA dehydrogenases (ACDs) are a family of mitochondrial enzymes that oxidize straight chain or branched chain acyl-CoAs in the metabolism of fatty…”
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Double Expressing (MYC/BCL2) and Double-Hit Diffuse Large B-Cell Lymphomas Have Inferior Survival Following Autologous Stem Cell Transplantation by Herrera, Alex F., Mei, Matthew G., Low, Lawrence, Merryman, Reid W., Song, Joo Y., Paris, Tanya, Stiller, Tracey, Bedell, Victoria, Sun, Heather, Brown, Jennifer R., Budde, Lihua Elizabeth, Chen, Robert, Davids, Matthew S., Freedman, Arnold S., Fisher, David C., Jacobsen, Eric D., Jacobson, Caron A., Kim, Haesook T., LaCasce, Ann S., Murata-Collins, Joyce, Nademanee, Auayporn P., Palmer, Joycelynne, Pihan, German A., Siddiqi, Tanya, Sohani, Aliyah R, Popplewell, Leslie L., Zain, Jasmine, Kwak, Larry W., Weinstock, David M., Forman, Stephen J., Weisenburger, Dennis D., Kim, Young, Rodig, Scott J., Krishnan, Amrita, Armand, Philippe

“…Background: Double-hit lymphomas (DHL) are a subset of diffuse large B-cell lymphoma (DLBCL) with concurrent chromosomal rearrangements involving the MYC and…”
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Genetic discrimination in life insurance: empirical evidence from a cross sectional survey of genetic support groups in the United Kingdom by Low, Lawrence, King, Suzanne, Wilkie, Tom

“…Abstract Objectives: To gather empirical evidence on any discrimination based on genetic information shown by the insurance industry in the United Kingdom and…”
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Molecular modelling of the mouse cytochrome P450 CYP2F2 based on the CYP102 crystal structure template and selective CYP2F2 substrate interactions by Lewis, David F V, Bailey, Paul T, Low, Lawrence K

“…The results of homology modelling of the mouse cytochrome P450, CYP2F2, are reported, based on the CYP102 crystallographic template. It is found that selective…”
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