Search Results - "Low, Felicia M."

Evolutionary and developmental mismatches are consequences of adaptive developmental plasticity in humans and have implications for later disease risk by Gluckman, Peter D, Hanson, Mark A, Low, Felicia M

“…A discrepancy between the phenotype of an individual and that which would confer optimal responses in terms of fitness in an environment is termed 'mismatch'…”
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The role of developmental plasticity and epigenetics in human health by Gluckman, Peter D., Hanson, Mark A., Low, Felicia M.

“…Considerable epidemiological, experimental and clinical data have amassed showing that the risk of developing disease in later life is dependent on early life…”
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Peroxiredoxin 2 and peroxide metabolism in the erythrocyte by Low, Felicia M, Hampton, Mark B, Winterbourn, Christine C

“…Peroxiredoxin 2 (Prx2) is an antioxidant enzyme that uses cysteine residues to decompose peroxides. Prx2 is the third most abundant protein in erythrocytes,…”
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Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte by Low, Felicia M., Hampton, Mark B., Peskin, Alexander V., Winterbourn, Christine C.

“…Peroxiredoxin 2 (Prx2), a thiol-dependent peroxidase, is the third most abundant protein in the erythrocyte, and its absence in knock-out mice gives rise to…”
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The High Reactivity of Peroxiredoxin 2 with H2O2 Is Not Reflected in Its Reaction with Other Oxidants and Thiol Reagents by Peskin, Alexander V., Low, Felicia M., Paton, Louise N., Maghzal, Ghassan J., Hampton, Mark B., Winterbourn, Christine C.

“…Peroxiredoxin 2 is a member of the mammalian peroxiredoxin family of thiol proteins that is important in antioxidant defense and redox signaling. We have…”
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Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane by Bayer, Simone B, Low, Felicia M, Hampton, Mark B, Winterbourn, Christine C

“…Peroxiredoxin 2 (Prx2) is an abundant antioxidant protein in erythrocytes that protects against hemolytic anemia resulting from hemoglobin oxidation and Heinz…”
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Epigenetic epidemiology: the rebirth of soft inheritance by Hanson, Mark A, Low, Felicia M, Gluckman, Peter D

“…Non-communicable diseases (NCDs), such as cardiovascular disease and type 2 diabetes, constitute the main cause of death worldwide. Eighty percent of these…”
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Epigenetic mechanisms that underpin metabolic and cardiovascular diseases by Gluckman, Peter D, Hanson, Mark A, Buklijas, Tatjana, Low, Felicia M, Beedle, Alan S

“…An organism's ability to adjust its phenotypic development to the environment is partly determined by epigenetic changes that are established in early life and…”
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Niche Modification, Human Cultural Evolution and the Anthropocene by Low, Felicia M., Gluckman, Peter D., Hanson, Mark A.

“…Niche-constructing organisms actively modify their environments with adaptive consequences, sustaining a new equilibrium. Modern humans are instead niche…”
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Maternal and child health: is making ‘healthy choices’ an oxymoron? by Low, Felicia M., Gluckman, Peter D., Hanson, Mark A.

“…The right to exercise choice is fundamental to the Universal Declaration of Human Rights, and it is assumed that all individuals generally enjoy freedom of…”
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How evolutionary principles improve the understanding of human health and disease by Gluckman, Peter D., Low, Felicia M., Buklijas, Tatjana, Hanson, Mark A., Beedle, Alan S.

“…An appreciation of the fundamental principles of evolutionary biology provides new insights into major diseases and enables an integrated understanding of…”
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Anthropocene-related disease: The inevitable outcome of progressive niche modification? by Gluckman, Peter D, Low, Felicia M, Hanson, Mark A

“…While the Anthropocene is often discussed in terms of the health of the planet, there has been less attention paid to its impact on the health of humans. We…”
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Developmental plasticity and epigenetic mechanisms underpinning metabolic and cardiovascular diseases by Low, Felicia M, Gluckman, Peter D, Hanson, Mark A

“…The importance of developmental factors in influencing the risk of later-life disease has a strong evidence base derived from multiple epidemiological,…”
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The future of evolutionary medicine: sparking innovation in biomedicine and public health by Natterson-Horowitz, B., Aktipis, Athena, Fox, Molly, Gluckman, Peter D., Low, Felicia M., Mace, Ruth, Read, Andrew, Turner, Paul E., Blumstein, Daniel T.

“…Evolutionary medicine – i.e. the application of insights from evolution and ecology to biomedicine – has tremendous untapped potential to spark…”
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Anthropocene-related disease by Gluckman, Peter D, Low, Felicia M, Hanson, Mark A

“…While the Anthropocene is often discussed in terms of the health of the planet, there has been less attention paid to its impact on the health of humans. We…”
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Developmental Plasticity, Epigenetics and Human Health by Low, Felicia M., Gluckman, Peter D., Hanson, Mark A.

“…The unrelenting rise in global rates of non-communicable disease has necessitated a thorough re-evaluation of the current use of adult- and lifestyle-based…”
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Human growth: evolutionary and life history perspectives by Gluckman, Peter D, Beedle, Alan S, Hanson, Mark A, Low, Felicia M

“…Evolutionary and life history perspectives allow a fuller understanding of both patterns of growth and development and variations in disease risk. Evolutionary…”
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Developing a Curriculum for Evolutionary Medicine: Case Studies of Scurvy and Female Reproductive Tract Cancers by Buklijas, Tatjana, Low, Felicia M., Beedle, Alan S., Gluckman, Peter D.

“…Most early evolutionary thinkers came from medicine, yet evolution has had a checkered history in medical education. It is only in the last few decades that…”
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Evolutionary and developmental mismatches are consequences of adaptive developmental plasticity in humans and have implications for later disease risk by Gluckman, Peter D., Hanson, Mark A., Low, Felicia M.

“…A discrepancy between the phenotype of an individual and that which would confer optimal responses in terms of fitness in an environment is termed 'mismatch'…”
Get full text

The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents by Peskin, Alexander V, Low, Felicia M, Paton, Louise N, Maghzal, Ghassan J, Hampton, Mark B, Winterbourn, Christine C

“…Peroxiredoxin 2 is a member of the mammalian peroxiredoxin family of thiol proteins that is important in antioxidant defense and redox signaling. We have…”
Get full text