Search Results - "Low, Caroline M.R."

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo by Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.

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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo by Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.

“…Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no…”
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Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors by Alshaker, Heba, Srivats, Shyam, Monteil, Danielle, Wang, Qi, Low, Caroline M. R., Pchejetski, Dmitri

“…Purpose Sphingosine kinase 1 (SK1) is a protooncogenic enzyme expressed in many human tumours and is associated with chemoresistance and poor prognosis. It is…”
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Ultrasound in synthesis: natural products and supersonic reactions? by Low, Caroline M.R

“…Sonochemical syntheses of a number of useful reagents such as samarium diiodide, sodium phenylselenide, tertiary alkoxides and the reducing agent [(PPh 3P)CuH]…”
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Solvent Effects on Hydrogen Bonding by Cook, Joanne L., Hunter, Christopher A., Low, Caroline M. R., Perez-Velasco, Alejandro, Vinter, Jeremy G.

“…Environmental issues: The stability of the 1:1 hydrogen‐bonded complex formed between tri‐n‐butylphosphine oxide (A) and perfluoro‐tert‐butyl alcohol (DH) has…”
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Substituent effects on aromatic stacking interactions by Cockroft, Scott L, Perkins, Julie, Zonta, Cristiano, Adams, Harry, Spey, Sharon E, Low, Caroline M R, Vinter, Jeremy G, Lawson, Kevin R, Urch, Christopher J, Hunter, Christopher A

“…Synthetic supramolecular zipper complexes have been used to quantify substituent effects on the free energies of aromatic stacking interactions. The…”
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Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors by Sacre, Sandra, Jaxa-Chamiec, Albert, Low, Caroline M R, Chamberlain, Giselle, Tralau-Stewart, Cathy

“…Antidepressants are increasingly recognized to have anti-inflammatory properties in addition to their ability to treat major depressive disorders. To explore…”
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Influence of Solvent Polarity on Preferential Solvation of Molecular Recognition Probes in Solvent Mixtures by Amenta, Valeria, Cook, Joanne L, Hunter, Christopher A, Low, Caroline M. R, Vinter, Jeremy G

“…The association constants for formation of 1:1 complexes between a H-bond acceptor, tri-n-butylphosphine oxide, and a H-bond donor, 4-phenylazophenol, have…”
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Interplay of Self-Association and Solvation in Polar Liquids by Amenta, Valeria, Cook, Joanne L, Hunter, Christopher A, Low, Caroline M. R, Sun, Hongmei, Vinter, Jeremy G

“…The association constants for formation a 1:1 complex between 4-phenyl azophenol and tri-n-butylphosphine oxide were measured in mixtures of n-octane and…”
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UK academic drug discovery by Tralau-Stewart, Cathy, Low, Caroline M. R., Marlin, Nicola

“…Tralau-Stewart and colleagues present a survey of the academic drug discovery environment in the United Kingdom in 2013, and discuss the major trends in…”
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Preferential Solvation and Hydrogen Bonding in Mixed Solvents by Cook, Joanne L., Hunter, Christopher A., Low, Caroline M. R., Perez-Velasco, Alejandro, Vinter, Jeremy G.

“…Oak trees from acorns: A small amount (<1 %) of a cosolvent can change the stability of the H‐bonded complex on the right‐hand side of the equation by an order…”
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UK academic drug discovery by Tralau-Stewart, Cathy, Low, Caroline M.R, Marlin, Nicola

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Rationalizing the Activities of Diverse Cholecystokinin 2 Receptor Antagonists Using Molecular Field Points by Low, Caroline M. R, Vinter, J. G

“…Cholecystokinin 2 receptor antagonists encompass a wide range of structures. This makes them unsuitable candidates for existing 3D-QSAR methods and has led us…”
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Molecular recognition probes of solvation thermodynamics in solvent mixtures by Amenta, Valeria, Cook, Joanne L, Hunter, Christopher A, Low, Caroline M R, Vinter, Jeremy G

“…High-throughput UV-Vis experiments using four molecular recognition-based probes, made by the combination of two hydrogen bond acceptors, tri-n-butylphosphine…”
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Substituent Effects on Cation-π Interactions: A Quantitative Study by Hunter, Christopher A., Caroline M. R. Low, Rotger, Carmen, Vinter, Jeremy G., Zonta, Cristiano

“…A synthetic supramolecular complex has been adapted to quantify cation-π interactions in chloroform by using chemical double-mutant cycles. The interaction of…”
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Discovery and Characterization of Novel, Potent, Non-Peptide Parathyroid Hormone-1 Receptor Antagonists by McDonald, Iain M, Austin, Carol, Buck, Ildiko M, Dunstone, David J, Gaffen, John, Griffin, Eric, Harper, Elaine A, Hull, Robert A. D, Kalindjian, S. Barret, Linney, Ian D, Low, Caroline M. R, Patel, Dipa, Pether, Michael J, Raynor, Michelle, Roberts, Sonia P, Shaxted, Mark E, Spencer, John, Steel, Katherine I. M, Sykes, David A, Wright, Paul T, Xun, Wei

“…A 1,3,4-benzotriazepine was identified as a suitable lead in our effort toward obtaining a non-peptide parathyroid hormone-1 receptor (PTH1R) antagonist. A…”
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Scaffold Hopping with Molecular Field Points:  Identification of a Cholecystokinin-2 (CCK2) Receptor Pharmacophore and Its Use in the Design of a Prototypical Series of Pyrrole- and Imidazole-Based CCK2 Antagonists by Low, Caroline M. R, Buck, Ildiko M, Cooke, Tracey, Cushnir, Julia R, Kalindjian, S. Barret, Kotecha, Atul, Pether, Michael J, Shankley, Nigel P, Vinter, J. G, Wright, Laurence

“…A new molecular modeling approach has been used to derive a pharmacophore of the potent and selective cholecystokinin-2 (CCK2) receptor antagonist 5 (JB93182),…”
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Noncovalent Assembly of [2]Rotaxane Architectures by Hunter, Christopher A., Low, Caroline M. R., Packer, Martin J., Spey, Sharon E., Vinter, Jeremy G., Vysotsky, Myroslav O., Zonta, Cristiano

“…Reversible zinc–pyridine coordination and hydrogen‐bonding interactions have been used to assemble a [2]rotaxane from three components. Cooperativity in the…”
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Quantitative Determination of Intermolecular Interactions with Fluorinated Aromatic Rings by Adams, Harry, Jimenez Blanco, Jose-Luis, Chessari, Gianni, Hunter, Christopher A., Low, Caroline M. R., Sanderson, John M., Vinter, Jeremy G.

“…The chemical double mutant cycle approach has been used to investigate substituent effects on intermolecular interactions between aromatic rings and…”
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An Evaluation of Force-Field Treatments of Aromatic Interactions by Chessari, Gianni, Hunter, Christopher A., Low, Caroline M. R., Packer, Martin J., Vinter, Jeremy G., Zonta, Cristiano

“…Experimental measurements of edge‐to‐face aromatic interactions have been used to test a series of molecular mechanics force fields. The experimental data were…”
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