Search Results - "Lovshin, Julie A"

Incretin-based therapies for type 2 diabetes mellitus by Drucker, Daniel J, Lovshin, Julie A

“…Incretin-based drugs have several advantages over commonly used antidiabetic agents, including a glucose-dependent mechanism of action and no risk of weight…”
Get full text

Renal physiology of glucose handling and therapeutic implications by Cherney, David Z, Kanbay, Mehmet, Lovshin, Julie A

“…Abstract The rationale for using sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes (T2D) has evolved over the last decade. Due…”
Get full text

Dapagliflozin in focal segmental glomerulosclerosis: a combined human-rodent pilot study by Rajasekeran, Harindra, Reich, Heather N, Hladunewich, Michelle A, Cattran, Daniel, Lovshin, Julie A, Lytvyn, Yuliya, Bjornstad, Petter, Lai, Vesta, Tse, Josephine, Cham, Leslie, Majumder, Syamantak, Bowskill, Bridgit B, Kabir, M Golam, Advani, Suzanne L, Gibson, Ian W, Sood, Manish M, Advani, Andrew, Cherney, David Z I

“…Focal segmental glomerulosclerosis (FSGS) is an important cause of nondiabetic chronic kidney disease (CKD). Sodium-glucose cotransporter 2 inhibition (SGLT2i)…”
Get more information

Urinary adenosine excretion in type 1 diabetes by Rajasekeran, Harindra, Lytvyn, Yuliya, Bozovic, Andrea, Lovshin, Julie A, Diamandis, Eleftherios, Cattran, Daniel, Husain, Mansoor, Perkins, Bruce A, Advani, Andrew, Reich, Heather N, Kulasingam, Vathany, Cherney, David Z I

“…In experimental models of diabetes, augmented sodium-glucose cotransport-2 (SGLT2) activity diminishes sodium (Na ) delivery at the macula densa. As a result,…”
Get more information

Atherosclerosis and Microvascular Complications: Results From the Canadian Study of Longevity in Type 1 Diabetes by Lovshin, Julie A, Bjornstad, Petter, Lovblom, Leif E, Bai, Johnny-Wei, Lytvyn, Yuliya, Boulet, Geneviève, Farooqi, Mohammed A, Santiago, Sam, Orszag, Andrej, Scarr, Daniel, Weisman, Alanna, Keenan, Hillary A, Brent, Michael H, Paul, Narinder, Bril, Vera, Perkins, Bruce A, Cherney, David Z I

“…Type 1 diabetes carries a significant risk for cardiovascular mortality, but it is unclear how atherosclerosis associates with microvascular complications. We…”
Get full text

Validity of a point-of-care nerve conduction device for polyneuropathy identification in older adults with diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes by Scarr, Daniel, Lovblom, Leif E, Cardinez, Nancy, Orszag, Andrej, Farooqi, Mohammed A, Boulet, Genevieve, Weisman, Alanna, Lovshin, Julie A, Ngo, Mylan, Paul, Narinder, Keenan, Hillary A, Brent, Michael H, Cherney, David Z, Bril, Vera, Perkins, Bruce A

“…Point-of-care nerve conduction devices (POCD) have been studied in younger patients and may facilitate screening for polyneuropathy in non-specialized clinical…”
Get full text

Blood Pressure-Lowering Effects of Incretin-Based Diabetes Therapies by Lovshin, Julie A., MD, PhD, Zinman, Bernard, MD

“…Abstract Glucagon-like peptide-1 receptor (GLP-1) agonists and dipeptidyl-peptidase-4 (DPP-4) inhibitors are therapies that are used to treat hyperglycemia in…”
Get full text

Neuropathy and Presence of Emotional Distress and Depression in Longstanding Diabetes: Results From the Canadian Study of Longevity in Type 1 Diabetes by Bai, Johnny-Wei, Lovblom, Leif E, Cardinez, Marina, Weisman, Alanna, Farooqi, Mohammed A, Halpern, Elise M, Boulet, Genevieve, Eldelekli, Devrim, Lovshin, Julie A, Lytvyn, Yuliya, Keenan, Hillary A, Brent, Michael H, Paul, Narinder, Bril, Vera, Cherney, David Z.I, Perkins, Bruce A

“…Abstract Aim To determine the association of neuropathy and other complications with emotional distress and depression among patients with longstanding type 1…”
Get full text

Clinical inertia—a barrier to effective management of T2DM by Lovshin, Julie A., Zinman, Bernard

“…In routine primary care, clinicians are slow to intensify glycaemic management in patients with type 2 diabetes mellitus (T2DM), despite access to an…”
Get full text

Sodium Glucose Cotransporter-2 Inhibition in Heart Failure: Potential Mechanisms, Clinical Applications, and Summary of Clinical Trials by Lytvyn, Yuliya, Bjornstad, Petter, Udell, Jacob A, Lovshin, Julie A, Cherney, David Z.I

“…Despite current established therapy, heart failure (HF) remains a leading cause of hospitalization and mortality worldwide. Novel therapeutic targets are…”
Get full text

Glucagon-like Peptide-1 Receptor Agonists: A Class Update for Treating Type 2 Diabetes by Lovshin, Julie A.

“…Current management options for treating type 2 diabetes are diverse. Many different classes of antidiabetes therapies are used in clinic, and several new…”
Get full text

Liraglutide promotes natriuresis but does not increase circulating levels of atrial natriuretic peptide in hypertensive subjects with type 2 diabetes by Lovshin, Julie A, Barnie, Annette, DeAlmeida, Ariana, Logan, Alexander, Zinman, Bernard, Drucker, Daniel J

“…GLP-1 receptor (GLP-1R) agonists induce natriuresis and reduce blood pressure (BP) through incompletely understood mechanisms. We examined the effects of acute…”
Get full text

Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes by Sekercioglu, Nigar, Lovblom, Leif Erik, Bjornstad, Petter, Lovshin, Julie A., Lytvyn, Yuliya, Boulet, Geneviève, Farooqi, Mohammed A., Orszag, Andrej, Lai, Vesta, Tse, Josephine, Cham, Leslie, Keenan, Hillary A., Brent, Michael H., Paul, Narinder, Bril, Vera, Perkins, Bruce A., Cherney, David Z. I.

“…Objectives: Diabetic kidney disease (DKD) is an independent predictor of cardiovascular morbidity and mortality in type 1 diabetes (T1D). We aimed to explore…”
Get full text

Estimating GFR by Serum Creatinine, Cystatin C, and β2-Microglobulin in Older Adults: Results From the Canadian Study of Longevity in Type 1 Diabetes by Scarr, Daniel, Bjornstad, Petter, Lovblom, Leif E., Lovshin, Julie A., Boulet, Genevieve, Lytvyn, Yuliya, Farooqi, Mohammed A., Lai, Vesta, Orszag, Andrej, Weisman, Alanna, Keenan, Hillary A., Brent, Michael H., Paul, Narinder, Bril, Vera, Cherney, David Z.I., Perkins, Bruce A.

“…Glomerular filtration rate (GFR) is routinely used for clinical assessment of kidney function. However, the accuracy of estimating equations in older adults is…”
Get full text

Do effects of sodium–glucose cotransporter-2 inhibitors in patients with diabetes give insight into potential use in non-diabetic kidney disease? by Rajasekeran, Harindra, Cherney, David Z, Lovshin, Julie A

“…PURPOSE OF REVIEWOur aim was to review the rationale for the role of sodium–glucose cotransporter-2 inhibitors (SGLT-2i) as renoprotective therapy in patients…”
Get full text

Management of type 2 diabetes, obesity, or nonalcoholic steatohepatitis with high‐dose GLP‐1 receptor agonists and GLP‐1 receptor‐based co‐agonists by Goldenberg, Ronald M., Gilbert, Jeremy D., Manjoo, Priya, Pedersen, Sue D., Woo, Vincent C., Lovshin, Julie A.

“…Summary Type 2 diabetes (T2D), obesity, and nonalcoholic fatty liver disease/nonalacoholic steatohepatitis (NAFLD/NASH) share mutual causalities. Medications…”
Get full text

Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in the perioperative setting by Peacock, Sharon C., Lovshin, Julie A.

Get full text

Perioperative Considerations for the Use of Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes by Peacock, Sharon C, Lovshin, Julie A, Cherney, David Z I

Get full text

Hyperfiltration, urinary albumin excretion, and ambulatory blood pressure in adolescents with Type 1 diabetes mellitus by Lovshin, Julie A, Škrtić, Marko, Bjornstad, Petter, Moineddin, Rahim, Daneman, Denis, Dunger, David, Reich, Heather N, Mahmud, Farid, Scholey, James, Cherney, David Z I, Sochett, Etienne

“…Adolescents with Type 1 diabetes mellitus (T1DM) are at risk for hyperfiltration and elevated urinary albumin-to-creatinine ratio (ACR), which are early…”
Get more information

Estimated glomerular filtration rate calculated by serum creatinine lacks precision and accuracy in adults with type 2 diabetes with preserved renal function by Scarr, Daniel, Lovblom, Leif E., Bjornstad, Petter, Perkins, Bruce A., Kugathasan, Luxcia, Cherney, David Z.I., Lovshin, Julie A.

“…We evaluated the performance of creatinine-based equations that are currently used to estimate glomerular filtration rate (GFR) in people with type 2 diabetes…”
Get full text