Search Results - "Lovett, Susan T."

Generation and Repair of Postreplication Gaps in Escherichia coli by Cox, Michael M, Goodman, Myron F, Keck, James L, van Oijen, Antoine, Lovett, Susan T, Robinson, Andrew

“…When replication forks encounter template lesions, one result is lesion skipping, where the stalled DNA polymerase transiently stalls, disengages, and then…”
Get full text

Encoded errors: mutations and rearrangements mediated by misalignment at repetitive DNA sequences by Lovett, Susan T.

“…Summary Mutations and rearrangements that occur by misalignment during DNA replication are frequent sources of genetic variation in bacteria. Dislocations…”
Get full text

DNA polymerase III protein, HolC, helps resolve replication/transcription conflicts by Lovett, Susan T.

“…In Escherichia coli, DNA replication is catalyzed by an assembly of proteins, the DNA polymerase III holoenzyme. This complex includes the polymerase and…”
Get full text

Reconstitution of initial steps of dsDNA break repair by the RecF pathway of E. coli by Handa, Naofumi, Morimatsu, Katsumi, Lovett, Susan T, Kowalczykowski, Stephen C

“…The RecF pathway of Escherichia coli is important for recombinational repair of DNA breaks and gaps. Here ;we reconstitute in vitro a seven-protein reaction…”
Get full text

Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli by Cooper, Deani L, Lovett, Susan T

“…RadA (also known as 'Sms') is a highly conserved protein, found in almost all eubacteria and plants, with sequence similarity to the RecA strand exchange…”
Get full text

Genetic analysis of Escherichia coli RadA: functional motifs and genetic interactions by Cooper, Deani L., Boyle, Daniel C., Lovett, Susan T.

“…Summary The RadA/Sms protein is a RecA‐related protein found universally in eubacteria and plants, implicated in processing of recombination intermediates…”
Get full text

The stringent response and cell cycle arrest in Escherichia coli by Ferullo, Daniel J, Lovett, Susan T

“…The bacterial stringent response, triggered by nutritional deprivation, causes an accumulation of the signaling nucleotides pppGpp and ppGpp. We characterize…”
Get full text

The Role of Replication Clamp-Loader Protein HolC of Escherichia coli in Overcoming Replication/Transcription Conflicts by Cooper, Deani L, Harada, Taku, Tamazi, Samia, Ferrazzoli, Alexander E, Lovett, Susan T

“…In , DNA replication is catalyzed by an assembly of proteins, the DNA polymerase III holoenzyme. This complex includes the polymerase and proofreading…”
Get full text

Connecting Replication and Repair: YoaA, a Helicase-Related Protein, Promotes Azidothymidine Tolerance through Association with Chi, an Accessory Clamp Loader Protein by Brown, Laura T, Sutera, Jr, Vincent A, Zhou, Shen, Weitzel, Christopher S, Cheng, Yisha, Lovett, Susan T

“…Elongating DNA polymerases frequently encounter lesions or structures that impede progress and require repair before DNA replication can be completed…”
Get full text

Identifying Small Molecules That Promote Quasipalindrome-Associated Template-Switch Mutations in Escherichia coli by Klaric, Julie A, Perr, Eli L, Lovett, Susan T

“…DNA can assemble into non-B form structures that stall replication and cause genomic instability. One such secondary structure results from an inverted DNA…”
Get full text

Toxicity and tolerance mechanisms for azidothymidine, a replication gap-promoting agent, in Escherichia coli by Cooper, Deani L., Lovett, Susan T.

“…[Display omitted] ▶ AZT causes replication arrest in the bacterium, E. coli. ▶ AZT produces ssDNA gaps. ▶ AZT induces gap-filling recombination reactions. ▶…”
Get full text

Instability of Repetitive DNA Sequences: The Role of Replication in Multiple Mechanisms by Bzymek, M, Lovett, S T

“…Rearrangements between tandem sequence homologies of various lengths are a major source of genomic change and can be deleterious to the organism. These…”
Get full text

Growth Phase and (p)ppGpp Control of IraD, a Regulator of RpoS Stability, in Escherichia coli by Merrikh, Houra, Ferrazzoli, Alexander E, Lovett, Susan T

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

DNA damage response in Escherichia coli involving the alternative sigma factor, RpoS by Merrikh, Houra, Ferrazzoli, Alexander E, Bougdour, Alexandre, Olivier-Mason, Anique, Lovett, Susan T

“…We isolated an Escherichia coli mutant in the iraD gene, sensitive to various forms of DNA damage. Our data are consistent with the function of IraD to promote…”
Get full text

Azidothymidine and other chain terminators are mutagenic for template-switch-generated genetic mutations by Seier, Tracey, Zilberberg, Gal, Zeiger, Danna M, Lovett, Susan T

“…The accumulation of mutations causes cell lethality and can lead to carcinogenesis. An important class of mutations, which are associated with mutational…”
Get full text

RecA-independent recombination is efficient but limited by exonucleases by Dutra, Bethany E, Sutera, Vincent A. Jr, Lovett, Susan T

“…Genetic recombination in bacteria is facilitated by the RecA strand transfer protein and strongly depends on the homology between interacting sequences…”
Get full text

Template-switching during replication fork repair in bacteria by Lovett, Susan T.

“…Replication forks frequently are challenged by lesions on the DNA template, replication-impeding DNA secondary structures, tightly bound proteins or nucleotide…”
Get full text

ObgE/CgtA GTPase influences the stringent response to amino acid starvation in Escherichia coli by Persky, Nicole S, Ferullo, Daniel J, Cooper, Deani L, Moore, Hayley R, Lovett, Susan T

“…The stringent response is important for bacterial survival under stressful conditions, such as amino acid starvation, and is characterized by the accumulation…”
Get full text

The DNA damage response of Escherichia coli , revisited: Differential gene expression after replication inhibition by Sass, Thalia H, Lovett, Susan T

“…In 1967, in this journal, Evelyn Witkin proposed the existence of a coordinated DNA damage response in , which later came to be called the "SOS response." We…”
Get full text

Between sisters: Watching replication-associated recombinational DNA repair by Lovett, Susan T

“…Amarh et al. (2018. https://doi.org/10.1083/jcb.201803020) visualize for the first time the repair of double-strand breaks during DNA replication. As viewed by…”
Get full text