Search Results - "Loves, W. J."

Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines by BERGMAN, A. M, PINEDO, H. M, TALIANIDIS, I, VEERMAN, G, LOVES, W. J. P, VAN DER WILT, C. L, PETERS, G. J

“…Gemcitabine (2',2'-difluorodeoxycytidine) is a deoxycytidine analogue that is activated by deoxycytidine kinase (dCK) to its monophosphate and subsequently to…”
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Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines by KROEP, J. R, GIACCONE, G, TOLIS, C, VOORN, D. A, LOVES, W. J. P, VAN GROENINGEN, C. J, PINEDO, H. M, PETERS, G. J

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Quantitative Real Time PCR of Deoxycytidine Kinase mRNA by Light Cycler PCR; in Relation to Enzyme Activity by Sigmond, J., Loves, W. J., Kroep, J. R., Peters, G. J.

“…Deoxycytidine kinase (dCK) is essential for the phosphorylation of several deoxyribonucleosides and various analogues such as gemcitabine…”
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Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines by Kroep, J R, Giaccone, G, Tolis, C, Voorn, D A, Loves, W J, Groeningen, C J, Pinedo, H M, Peters, G J

“…Gemcitabine and paclitaxel are active agents in the treatment of non-small-cell lung cancer (NSCLC). To optimize treatment drug combinations, simultaneously…”
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Intravesical administration of gemcitabine in superficial bladder cancer: a phase I study with pharmacodynamic evaluation by De Berardinis, E., Antonini, G., Peters, G.J., Loves, W.J.P., Van Der Born, K., Codacci‐Pisanelli, G., Di Silverio, F.

“…OBJECTIVE To determine, in a phase I trial, the local and systemic toxicity and pharmacodynamics of intravesical gemcitabine in patients with superficial…”
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Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver by van der Wilt, C.L, Kroep, J.R, Loves, W.J.P, Rots, M.G, Van Groeningen, C.J, Kaspers, G.J, Peters, G.J

“…Deoxycytidine kinase (dCK) is required for the phosphorylation of several deoxyribonucleoside analogues that are widely employed as chemotherapeutic agents…”
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Enhanced Activity of Deoxycytidine Kinase After Pulsed Low Dose Rate and Single Dose Gamma Irradiation by Sigmond, J., Haveman, J., Kreder, N. Castro, Loves, W. J., van Bree, C., Franken, N. A., Peters, G. J.

“…In both pulsed low dose rate (LDR) and single high dose radiation schedules, gemcitabine pretreatment sensitizes tumor cells to radiation. These…”
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Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines by van Moorsel, Catharina J.A, Pinedo, Herbert M, Veerman, Gijsbert, Guechev, Assen, Smid, Kees, Loves, Willem J.P, Vermorken, Jan B, Postmus, Pieter E, Peters, Godefridus J

“…Gemcitabine (2′,2′-difluorodeoxycytidine, dFdC) and etoposide (4′-demethylepipodo-phyllotoxin-9-4,6- O-ethylidene-β- d-glucopyranoside, VP-16) are…”
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The role of deoxycytidine kinase in gemcitabine cytotoxicity by van der Wilt, C L, Kroep, J R, Bergman, A M, Loves, W J, Alvarez, E, Talianidis, I, Eriksson, S, van Groeningen, C J, Pinedo, H M, Peters, G J

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