Search Results - "Lovell, D. P."

Reduced adhesion formation following laparoscopic versus open colorectal surgery by Dowson, H. M., Bong, J. J., Lovell, D. P., Worthington, T. R., Karanjia, N. D., Rockall, T. A.

“…Background: Adhesion formation is common after abdominal surgery. This study aimed to compare the extent of adhesion formation following laparoscopic and open…”
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Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment by Johnson, G.E., Soeteman-Hernández, L.G., Gollapudi, B.B., Bodger, O.G., Dearfield, K.L., Heflich, R.H., Hixon, J.G., Lovell, D.P., MacGregor, J.T., Pottenger, L.H., Thompson, C.M., Abraham, L., Thybaud, V., Tanir, J.Y., Zeiger, E., van Benthem, J., White, P.A.

“…Genetic toxicology data have traditionally been employed for qualitative, rather than quantitative evaluations of hazard. As a continuation of our earlier…”
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Quantitative approaches for assessing dose-response relationships in genetic toxicology studies by Gollapudi, B.B., Johnson, G.E., Hernandez, L.G., Pottenger, L.H., Dearfield, K.L., Jeffrey, A.M., Julien, E., Kim, J.H., Lovell, D.P., MacGregor, J.T., Moore, M.M., van Benthem, J., White, P.A., Zeiger, E., Thybaud, V.

“…Genetic toxicology studies are required for the safety assessment of chemicals. Data from these studies have historically been interpreted in a qualitative,…”
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Validation and reproducibility of a semi-quantitative Food Frequency Questionnaire for use in elderly Swiss women by Dumartheray, E. Wynn, Krieg, M-A, Cornuz, J, Whittamore, D.R, Lovell, D.P, Burckhardt, P, Lanham-New, S.A

“…The principal aim of this study was to develop a Swiss Food Frequency Questionnaire (FFQ) for the elderly population for use in a study to investigate the…”
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Indicators of bacterial infection in patients with acute exacerbation of chronic bronchitis for application in clinical trials of antibacterial drugs by Burley, C.J, Masterton, R.G, Lovell, D.P

“…Summary Objectives This study examined the accuracy of: (a) patient symptoms; (b) microscopic examination of sputum purulence (>25 WBCs and <10 epithelial…”
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Analysis of historical negative control group data from the rat in vivo micronucleus assay by Lovell, D.P., Fellows, M., Saul, J., Whitwell, J., Custer, L., Dertinger, S., Escobar, P., Fiedler, R., Hemmann, U., Kenny, J., Smith, R., van der Leede, B.M., Zeller, A.

“…•Historical negative control data are important for assessing data quality and for interpretation of the in vivo micronucleus assay•10 laboratories’ data from…”
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Gleason Scoring Varies Among Pathologists and this Affects Clinical Risk in Patients with Prostate Cancer by Sooriakumaran, P., Lovell, D.P., Henderson, A., Denham, P., Langley, S.E.M., Laing, R.W.

“…To investigate whether our practice of specialist review of all diagnostic biopsies was necessary to prevent misgrading of referred prostate cancer patients,…”
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Dose–response and threshold-mediated mechanisms in mutagenesis: statistical models and study design by Lovell, David P

“…The objective of this paper is to review the use, in mutagenesis, of various mathematical models to describe the dose–response relationship and to try to…”
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The cyclin-dependent kinase inhibitor p57 Kip2 is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer by COLEY, H. M, SAFUWAN, N. A. M, CHIVERS, P, PAPACHARALBOUS, E, GIANNOPOULOS, T, BUTLER-MANUEL, S, MADHURI, K, LOVELL, D. P, CROOK, T

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The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer by Coley, H M, Safuwan, N A M, Chivers, P, Papacharalbous, E, Giannopoulos, T, Butler-Manuel, S, Madhuri, K, Lovell, D P, Crook, T

“…Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in…”
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Report of an Expert Panel on the reanalysis by Séralini et al. (2007) of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863) by Doull, J., Gaylor, D., Greim, H.A., Lovell, D.P., Lynch, B., Munro, I.C.

“…MON 863, a genetically engineered corn variety that contains the gene for modified Bacillus thuringiensis Cry3Bb1 protein to protect against corn rootworm, was…”
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Principal Component Analysis of Tissue Scores from Substances used in the COLIPA Eye Irritation Validation Study by Lovell, D.P

“…Principal component analyses (PCA) have been carried out on the tissue scores from Draize eye irritation tests on the 55 formulations and chemical ingredients…”
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Plasma antibody titres to heat shock proteins-60, -65 and-70: Their relationship to coronary risk factors in dyslipidaemic patients and healthy individuals by Ghayour-Mobarhan, M., Lamb, D. J., Lovell, D. P., Livingstone, C., Wang, T., Ferns, G. A. A.

“…Objective To investigate the factors that may affect antibody titres to heat shock proteins (Hsp)-60, -65 and -70, and serum C-reactive protein (CRP)…”
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Principal component analysis of Draize eye Irritation tissue scores from 72 samples of 55 chemicals in the ECETOC data bank by Lovell, D.P.

“…The multivariate statistical method Principal Component Analysis (PCA) has been applied to a set of data from the ECETOC reference chemical data bank. PCA is a…”
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The cyclin-dependent kinase inhibitor p57Kip2 is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer by Coley, H M, Safuwan, N A M, Chivers, P, Papacharalbous, E, Giannopoulos, T, Butler-Manuel, S, Madhuri, K, Lovell, D P, Crook, T

“…Background: Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately…”
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Report and summary of the major conclusions from Statistics in Genotoxicity Testing Working Group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999 by Lovell, D. P., Yoshimura, I., Hothorn, L. A., Margolin, B. H., Soper, K.

“…A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of…”
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Interaction between diet and sunlight exposure on vitamin D status in premenopausal women living in Southern England: preliminary analysis of the Vitamin D, Food Intake, Nutrition and Exposure to Sunlight in Southern England (D-FINES) Study by Darling, A. L., Lovell, D. P., Lee, P. A., Lee, W. T. K., Berry, J. L., Lanham-New, S. A.

“…The relative contribution of UVB exposure and dietary vitamin D intake to vitamin D status was assessed separately for Caucasian and Asian women because of the…”
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Sex and strain differences in mouse hepatic microsomal coumarin 7-hydroxylase activity by van Iersel, M, Walters, D G, Price, R J, Lovell, D P, Lake, B G

“…Hepatic microsomal coumarin 7-hydroxylase activity has been determined in male and female mice of strains A/J, AKR, BALB/c, CBA/Ca, C3H/He, C57BL/6J, DBA/2 and…”
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Analysis of chromosomal aberrations in workers exposed to low level benzene by Yardley-Jones, A, Anderson, D, Lovell, D P, Jenkinson, P C

“…Metaphase chromosome preparations were analysed as part of a larger study from a population occupationally exposed to benzene and compared with a control…”
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Population genetics of induced mutations by Lovell, D P

“…The contribution of induced mutations to the burden of genetic disease in the context of population genetics is considered. A clear distinction is made between…”
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