Search Results - "Lovell, D."

Compartmentalised acyl-CoA metabolism and roles in chromatin regulation by Trefely, Sophie, Lovell, Claudia D., Snyder, Nathaniel W., Wellen, Kathryn E.

“…Many metabolites serve as important signalling molecules to adjust cellular activities and functions based on nutrient availability. Links between acetyl-CoA…”
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Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes by Di Micco, Raffaella, Fontanals-Cirera, Barbara, Low, Vivien, Ntziachristos, Panagiotis, Yuen, Stephanie K, Lovell, Claudia D, Dolgalev, Igor, Yonekubo, Yoshiya, Zhang, Guangtao, Rusinova, Elena, Gerona-Navarro, Guillermo, Cañamero, Marta, Ohlmeyer, Michael, Aifantis, Iannis, Zhou, Ming-Ming, Tsirigos, Aristotelis, Hernando, Eva

“…Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member…”
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Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseases by Burmester, G R, Mease, P, Dijkmans, B A C, Gordon, K, Lovell, D, Panaccione, R, Perez, J, Pangan, A L

“…Clinical trials of tumour necrosis factor antagonists have raised questions about the potential risk of certain serious adverse events (SAE). To assess the…”
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An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma by Davalos, Veronica, Lovell, Claudia D., Von Itter, Richard, Dolgalev, Igor, Agrawal, Praveen, Baptiste, Gillian, Kahler, David J., Sokolova, Elena, Moran, Sebastian, Piqué, Laia, Vega-Saenz de Miera, Eleazar, Fontanals-Cirera, Barbara, Karz, Alcida, Tsirigos, Aristotelis, Yun, Chi, Darvishian, Farbod, Etchevers, Heather C., Osman, Iman, Esteller, Manel, Schober, Markus, Hernando, Eva

“…Metastatic melanoma develops once transformed melanocytic cells begin to de-differentiate into migratory and invasive melanoma cells with neural crest cell…”
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Decreased food intake is a risk factor for mortality in hospitalised patients: The NutritionDay survey 2006 by Hiesmayr, M, Schindler, K, Pernicka, E, Schuh, C, Schoeniger-Hekele, A, Bauer, P, Laviano, A, Lovell, A.D, Mouhieddine, M, Schuetz, T, Schneider, S.M, Singer, P, Pichard, C, Howard, P, Jonkers, C, Grecu, I, Ljungqvist, O

“…Summary Background & aims Malnutrition is a known risk factor for the development of complications in hospitalised patients. We determined whether eating only…”
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Reduced adhesion formation following laparoscopic versus open colorectal surgery by Dowson, H. M., Bong, J. J., Lovell, D. P., Worthington, T. R., Karanjia, N. D., Rockall, T. A.

“…Background: Adhesion formation is common after abdominal surgery. This study aimed to compare the extent of adhesion formation following laparoscopic and open…”
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Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment by Johnson, G.E., Soeteman-Hernández, L.G., Gollapudi, B.B., Bodger, O.G., Dearfield, K.L., Heflich, R.H., Hixon, J.G., Lovell, D.P., MacGregor, J.T., Pottenger, L.H., Thompson, C.M., Abraham, L., Thybaud, V., Tanir, J.Y., Zeiger, E., van Benthem, J., White, P.A.

“…Genetic toxicology data have traditionally been employed for qualitative, rather than quantitative evaluations of hazard. As a continuation of our earlier…”
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Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections by Douglas, Edward J. A., Wulandari, Sri W., Lovell, Scott D., Laabei, Maisem

“…Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and currently represents one of the most significant threats to global…”
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Role of ascospores in further spread of QoI-resistant cytochrome b alleles (G143A) in field populations of Mycosphaerella graminicola by FRAAIJE, B. A, COOLS, H. J, FOUNTAINE, J, LOVELL, D. J, MOTTERAM, J, WEST, J. S, LUCAS, J. A

“…ABSTRACT Strobilurin fungicides or quinone outside inhibitors (QoIs) have been used successfully to control Septoria leaf blotch in the United Kingdom since…”
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Thermal performance prediction of outdoor swimming pools by Lovell, D., Rickerby, T., Vandereydt, B., Do, L., Wang, X., Srinivasan, K., Chua, H.T.

“…The sizing of water heating plants for outdoor community swimming pools conventionally relies on empirical methods and industry guidelines that seldom account…”
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Quantitative approaches for assessing dose-response relationships in genetic toxicology studies by Gollapudi, B.B., Johnson, G.E., Hernandez, L.G., Pottenger, L.H., Dearfield, K.L., Jeffrey, A.M., Julien, E., Kim, J.H., Lovell, D.P., MacGregor, J.T., Moore, M.M., van Benthem, J., White, P.A., Zeiger, E., Thybaud, V.

“…Genetic toxicology studies are required for the safety assessment of chemicals. Data from these studies have historically been interpreted in a qualitative,…”
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Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism by Shojaee-Moradie, F, Baynes, K. C. R, Pentecost, C, Bell, J. D, Thomas, E. L, Jackson, N. C, Stolinski, M, Whyte, M, Lovell, D, Bowes, S. B, Gibney, J, Jones, R. H, Umpleby, A. M

“…Aims/hypothesis It is not known whether the beneficial effects of exercise training on insulin sensitivity are due to changes in hepatic and peripheral insulin…”
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Detection of tubule boundaries based on circular shortest path and polar‐transformation of arbitrary shapes by SU, R., ZHANG, C., PHAM, T.D., DAVEY, R., BISCHOF, L., VALLOTTON, P., LOVELL, D., HOPE, S., SCHMOELZL, S., SUN, C.

“…Summary In studies of germ cell transplantation, counting cells and measuring tubule diameters from different populations using labelled antibodies are…”
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Distribution and severity of weakness among patients with polymyositis, dermatomyositis and juvenile dermatomyositis by Harris-Love, M. O., Shrader, J. A., Koziol, D., Pahlajani, N., Jain, M., Smith, M., Cintas, H. L., McGarvey, C. L., James-Newton, L., Pokrovnichka, A., Moini, B., Cabalar, I., Lovell, D. J., Wesley, R., Plotz, P. H., Miller, F. W., Hicks, J. E., Rider, L. G.

“…Objective. To describe the distribution and severity of muscle weakness using manual muscle testing (MMT) in 172 patients with PM, DM and juvenile DM (JDM)…”
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A comparison of upper and lower body energetics during high-intensity exercise by Harvey, L, Wiegand, A, Solomon, C, Mclellan, C, Lovell, D

“…The aim of the present study was to measure and compare the aerobic, anaerobic alactic and anaerobic lactic energy system contribution during the 30-sec…”
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Development of a Log-Quadratic Model To Describe Microbial Inactivation, Illustrated by Thermal Inactivation of Clostridium botulinum by Stone, G, Chapman, B, Lovell, D

“…In the commercial food industry, demonstration of microbiological safety and thermal process equivalence often involves a mathematical framework that assumes…”
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Analysis of historical negative control group data from the rat in vivo micronucleus assay by Lovell, D.P., Fellows, M., Saul, J., Whitwell, J., Custer, L., Dertinger, S., Escobar, P., Fiedler, R., Hemmann, U., Kenny, J., Smith, R., van der Leede, B.M., Zeller, A.

“…•Historical negative control data are important for assessing data quality and for interpretation of the in vivo micronucleus assay•10 laboratories’ data from…”
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Etanercept in Children with Polyarticular Juvenile Rheumatoid Arthritis by Lovell, Daniel J, Giannini, Edward H, Reiff, Andreas, Cawkwell, Gail D, Silverman, Earl D, Nocton, James J, Stein, Leonard D, Gedalia, Abraham, Ilowite, Norman T, Wallace, Carol A, Whitmore, James, Finck, Barbara K

“…Juvenile rheumatoid arthritis is the most common rheumatic condition in children. 1 , 2 In approximately one third of patients, the disease is controlled with…”
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Development of a provisional core set of response measures for clinical trials of systemic sclerosis by Khanna, D, Lovell, D J, Giannini, E, Clements, P J, Merkel, P A, Seibold, J R, Matucci-Cerinic, M, Denton, C P, Mayes, M D, Steen, V D, Varga, J, Furst, D E

“…To develop a provisional core set of response measures for clinical trials of systemic sclerosis (SSc). The Scleroderma Clinical Trials Consortium (SCTC)…”
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Seasonal changes in soil microbial communities along a fertility gradient of temperate grasslands by Bardgett, Richard D., Lovell, Roger D., Hobbs, Phil J., Jarvis, Steve C.

“…This study aimed to: (1) determine whether soil microbial communities along a gradient from intensive (fertilized) to low-input (unfertilized) grassland…”
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