Search Results - "Loveland, Kate"

TGF-β superfamily signaling in testis formation and early male germline development by Young, Julia C., Wakitani, Shoichi, Loveland, Kate L.

“…The TGF-β ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm…”
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Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse by Klein, Britta, Bhushan, Sudhanshu, Günther, Stefan, Middendorff, Ralf, Loveland, Kate L, Hedger, Mark P, Meinhardt, Andreas

“…Abstract Ascending bacterial urinary tract infections can cause epididymo-orchitis. In the cauda epididymidis, this frequently leads to persistent tissue…”
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Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia by Klein, Britta, Haggeney, Thomas, Fietz, Daniela, Indumathy, Sivanjah, Loveland, Kate L., Hedger, Mark, Kliesch, Sabine, Weidner, Wolfgang, Bergmann, Martin, Schuppe, Hans-Christian

“…Abstract STUDY QUESTION Which immune cells and cytokine profiles are characteristic for testicular germ cell neoplasia and what consequences does this have for…”
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New horizons in testis biology and men's health: a special issue of the XXVIth North American testis workshop by Yan, Wei, Loveland, Kate L.

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In the Shadow of Fibrosis: Innate Immune Suppression Mediated by Transforming Growth Factor-β by Thomas, Belinda J, Kan-O, Keiko, Loveland, Kate L, Elias, Jack A, Bardin, Philip G

“…Transforming growth factor-β (TGFB) regulates cell proliferation, differentiation, apoptosis, and matrix homeostasis and is intimately involved in fibrosis…”
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Genetics of testicular cancer: a review by Martin, Felicity C., Conduit, Ciara, Loveland, Kate L., Thomas, Benjamin, Lewin, Jeremy, Tran, Ben

“…Purpose of review Testicular germ cell tumours (TGCTs) are the most common solid malignant cancer diagnosed in young males and the incidence is increasing…”
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Importins: Diverse roles in male fertility by Nathaniel, Benedict, Whiley, Penny A.F., Miyamoto, Yoichi, Loveland, Kate L.

“…Regulated nucleocytoplasmic transport is central to the changes in gene expression that underpin cellular development and homeostasis, including in the testis,…”
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Dicer1 Is Required for Differentiation of the Mouse Male Germline by Maatouk, Danielle M, Loveland, Kate L, McManus, Michael T, Moore, Karen, Harfe, Brian D

“…MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. Hundreds of miRNAs are expressed in mammals; however, their…”
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Regulated Wnt/beta-catenin signaling sustains adult spermatogenesis in mice by Kerr, Genevieve E, Young, Julia C, Horvay, Katja, Abud, Helen E, Loveland, Kate L

“…The importance of Wnt signaling for postnatal testis function has been previously studied in several mouse models, with chronic pathway disruption addressing…”
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The changing landscape of immune cells in the fetal mouse testis by Hosseini, Samira, Moody, Sarah C., Fietz, Daniela, Indumathy, Sivanjah, Schuppe, Hans-Christian, Hedger, Mark P., Loveland, Kate L.

“…Fetal testis growth involves cell influx and extensive remodeling. Immediately after sex determination in mouse, macrophages enable normal cord formation and…”
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Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia by Sartori, Roberta, Hagg, Adam, Zampieri, Sandra, Armani, Andrea, Winbanks, Catherine E, Viana, Laís R, Haidar, Mouna, Watt, Kevin I, Qian, Hongwei, Pezzini, Camilla, Zanganeh, Pardis, Turner, Bradley J, Larsson, Anna, Zanchettin, Gianpietro, Pierobon, Elisa S, Moletta, Lucia, Valmasoni, Michele, Ponzoni, Alberto, Attar, Shady, Da Dalt, Gianfranco, Sperti, Cosimo, Kustermann, Monika, Thomson, Rachel E, Larsson, Lars, Loveland, Kate L, Costelli, Paola, Megighian, Aram, Merigliano, Stefano, Penna, Fabio, Gregorevic, Paul, Sandri, Marco

“…Most patients with advanced solid cancers exhibit features of cachexia, a debilitating syndrome characterized by progressive loss of skeletal muscle mass and…”
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Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitis by Peng, Wei, Kepsch, Artem, Kracht, Till O., Hasan, Hiba, Wijayarathna, Rukmali, Wahle, Eva, Pleuger, Christiane, Bhushan, Sudhanshu, Günther, Stefan, Kauerhof, A. Christine, Planinić, Ana, Fietz, Daniela, Schuppe, Hans-Christian, Wygrecka, Małgorzata, Loveland, Kate L., Ježek, Davor, Meinhardt, Andreas, Hedger, Mark P., Fijak, Monika

“…Experimental autoimmune-orchitis (EAO), a rodent model of chronic testicular inflammation and fibrosis, replicates pathogenic changes seen in some cases of…”
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T cells in testicular germ cell tumors: new evidence of fundamental contributions by rare subsets by Islam, Rashidul, Heyer, Jannis, Figura, Miriam, Wang, Xiaoyan, Nie, Xichen, Nathaniel, Benedict, Indumathy, Sivanjah, Hartmann, Katja, Pleuger, Christiane, Fijak, Monika, Kliesch, Sabine, Dittmar, Florian, Pilatz, Adrian, Wagenlehner, Florian, Hedger, Mark, Loveland, Bruce, Hotaling, James H., Guo, Jingtao, Loveland, Kate L., Schuppe, Hans-Christian, Fietz, Daniela

“…Background Immune cell infiltration is heterogeneous but common in testicular germ cell tumors (TGCT) and pre-invasive germ cell neoplasia in situ (GCNIS)…”
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Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse by Miyamoto, Yoichi, Sasaki, Mitsuho, Miyata, Haruhiko, Monobe, Yoko, Nagai, Masahiro, Otani, Mayumi, Whiley, Penny A. F., Morohoshi, Akane, Oki, Shinya, Matsuda, Junichiro, Akagi, Ken‐ichi, Adachi, Jun, Okabe, Masaru, Ikawa, Masahito, Yoneda, Yoshihiro, Loveland, Kate L., Oka, Masahiro

“…Importin α proteins play a central role in the transport of cargo from the cytoplasm to the nucleus. In this study, we observed that male knock‐out mice for…”
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Prepubertal Mouse Testis Growth and Maturation and Androgen Production Are Acutely Sensitive to Di-n-butyl Phthalate by Moody, Sarah, Goh, Hoey, Bielanowicz, Amanda, Rippon, Paul, Loveland, Kate L, Itman, Catherine

“…Phthalates are plasticizers with widespread industrial, domestic, and medical applications. Epidemiological data indicating increased incidence of testicular…”
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Monocytes expressing activin A and CCR2 exacerbate chronic testicular inflammation by promoting immune cell infiltration by Hasan, Hiba, Peng, Wei, Wijayarathna, Rukmali, Wahle, Eva, Fietz, Daniela, Bhushan, Sudhanshu, Pleuger, Christiane, Planinić, Ana, Günther, Stefan, Loveland, Kate L, Pilatz, Adrian, Ježek, Davor, Schuppe, Hans-Christian, Meinhardt, Andreas, Hedger, Mark P, Fijak, Monika

“…Does the chemokine/chemokine receptor axis, involved in immune cell trafficking, contribute to the pathology of testicular inflammation and how does activin A…”
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WNT signalling in the normal human adult testis and in male germ cell neoplasms by Young, Julia C, Kerr, Genevieve, Micati, Diana, Nielsen, John E, Rajpert-De Meyts, Ewa, Abud, Helen E, Loveland, Kate L

“…Is WNT signalling functional in normal and/or neoplastic human male germ cells? Regulated WNT signalling component synthesis in human testes indicates that WNT…”
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Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice by Sakurai, Koki, Morita, Makiko, Aomine, Yoshiatsu, Matsumoto, Mitsunobu, Moriyama, Tetsuji, Kasahara, Emiko, Sekiyama, Atsuo, Otani, Mayumi, Oshima, Rieko, Loveland, Kate L., Yamada, Masami, Yoneda, Yoshihiro, Oka, Masahiro, Hikida, Takatoshi, Miyamoto, Yoichi

“…Importin α4, which is encoded by the Kpna4 gene, is a well-characterized nuclear-cytoplasmic transport factor known to mediate transport of transcription…”
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The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis by Glaser, Stefan, Lubitz, Sandra, Loveland, Kate L, Ohbo, Kazu, Robb, Lorraine, Schwenk, Frieder, Seibler, Jost, Roellig, Daniela, Kranz, Andrea, Anastassiadis, Konstantinos, Stewart, A Francis

“…Histone methylation is thought to be central to the epigenetic mechanisms that maintain and confine cellular identity in multi-cellular organisms. To examine…”
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Nuclear retention of importin α coordinates cell fate through changes in gene expression by Yasuda, Yoshinari, Miyamoto, Yoichi, Yamashiro, Tomoko, Asally, Munehiro, Masui, Ayumi, Wong, Chin, Loveland, Kate L, Yoneda, Yoshihiro

“…Various cellular stresses including oxidative stress induce a collapse of the Ran gradient, which causes accumulation of importin α in the nucleus and a…”
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