Search Results - "Loveland, B E"

Long‐Term Controlled Normoglycemia in Diabetic Non‐Human Primates After Transplantation with hCD46 Transgenic Porcine Islets by Van Der Windt, D. J., Bottino, R., Casu, A., Campanile, N., Smetanka, C., He, J., Murase, N., Hara, H., Ball, S., Loveland, B. E, Ayares, D., Lakkis, F. G., Cooper, D. K. C., Trucco, M.

“…Xenotransplantation of porcine islets into diabetic non‐human primates is characterized by (i) an initial massive graft loss possibly due to the instant…”
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Testicular immune cell populations and macrophage polarisation in adult male mice and the influence of altered activin A levels by Indumathy, S., Pueschl, D., Klein, B., Fietz, D., Bergmann, M., Schuppe, H.-C., Da Silva, N., Loveland, B.E., Hickey, M.J., Hedger, M.P., Loveland, K.L.

“…•Adult testicular leukocytes characterized via flow cytometry and confocal microscopy.•Mononuclear phagocyte and lymphocyte heterogeneity documented.•New…”
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An in vitro model demonstrates the potential of neoplastic human germ cells to influence the tumour microenvironment by Klein, B., Schuppe, H.‐C., Bergmann, M., Hedger, M. P., Loveland, B. E., Loveland, K. L.

“…Summary Testicular germ cell tumours (TGCT) typically contain high numbers of infiltrating immune cells, yet the functional nature and consequences of…”
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Identification and quantification of complement regulator CD46 on normal human tissues by JOHNSTONE, R. W, LOVELAND, B. E, MCKENZIE, I. F. C

“…CD46 is a cell-surface regulatory molecule that prevents lysis of autologous human cells by activated complement. It has been well characterized on leucocytes,…”
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Maternally Transmitted Antigen of Mice: A Model Transplantation Antigen by Lindahl, K F, Hermel, E, Loveland, B E, Wang, C R

“…Molecular identification proved Mta, the maternally transmitted antigen of mice, to be a model minor histocompatibility (H) antigen. It consists of a peptide,…”
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H-2M3 encodes the MHC class I molecule presenting the maternally transmitted antigen of the mouse by Wang, C R, Loveland, B E, Lindahl, K F

“…Mta, the maternally transmitted antigen of mice, is a hydrophobic, N-formylated mitochondrial peptide, MTF, presented on the cell surface to cytotoxic T…”
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Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing by Johnstone, R W, Russell, S M, Loveland, B E, McKenzie, I F

“…CD46 is a member of the regulators of complement activation (RCA) family and serves to protect autologous cells from complement mediated lysis. The CD46 gene…”
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Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses by Apostolopoulos, V, Pietersz, G A, Loveland, B E, Sandrin, M S, McKenzie, I F

“…The induction of CD8+ cytotoxic T lymphocytes (CTLs) is desirable for immunization against many diseases, and recombinant-synthetic peptide antigens are now…”
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Human dendritic cells pulsed with specific lipopeptides stimulate autologous antigen-specific T cells without the addition of exogenous maturation factors by Jones, K. L., Brown, L. E., Eriksson, E. M. Y., Ffrench, R. A., Latour, P. A., Loveland, B. E., Wall, D. M., Roberts, S. K., Jackson, D. C., Gowans, E. J.

“…Serum‐free culture conditions to generate immature human monocyte‐derived DC (Mo‐DC) were optimized, and the parameters that influence their maturation after…”
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Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection by Loveland, B E, Hogarth, P M, Ceredig, R, McKenzie, I F

“…The Ly phenotype of cells mediating skin graft rejection was determined using monoclonal anti-Lyt-1.1 and Lyt-2.1 antibodies in CBA mice that received CBA…”
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Are PIGS transgenic for human complement regulatory proteins necessary for xenotransplantation? by LOVELAND, B. E, COOPER, D. K. C, SANDRIN, M. S

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Autoreactive cytotoxic T cells in mice are induced by immunization with a conserved mitochondrial enzyme in Freund’s complete adjuvant by Karanikas, V, Rowley, M J, MacKay, I R, Loveland, B E

“…Standard methods to generate autoimmune reactions in mice, by immunization with antigens emulsified with adjuvants, stimulate strong helper (CD4) T‐cell and…”
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Engineering of recombinant soluble CD46: an inhibitor of complement activation by Christiansen, D, Milland, J, Thorley, B R, McKenzie, I F, Mottram, P L, Purcell, L J, Loveland, B E

“…Human CD46 (membrane cofactor protein) is a type 1 glycoprotein that functions to protect autologous cells from complement-mediated damage by binding C3b and…”
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Coordinate functions of multiple complement regulating molecules, CD46, CD55, and CD59 by Loveland, B E, Szokolai, K, Johnstone, R W, McKenzie, I F

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Construction of CD46 minigenes for the production of transgenic mice by Thorley, B R, McInnes, B, Christiansen, D, McKenzie, I F, Loveland, B E

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Functional characterisation of alternatively spliced CD46 cytoplasmic tails by Russell, S M, Loveland, B E, Johnstone, R W, Thorley, B R, McKenzie, I F

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Tissue-specific expression of CD46 protein isoforms due to production of RNA splice variants by Johnstone, R W, Russell, S, Loveland, B E, McKenzie, I F

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Autoantibody against dihydrolipoamide dehydrogenase, the E3 subunit of the 2-oxoacid dehydrogenase complexes: significance for primary biliary cirrhosis by Maeda, T, Loveland, B E, Rowley, M J, Mackay, I R

“…Autoantibodies in primary biliary cirrhosis recognize mitochondrial 2-oxacid dehydrogenase complexes, particularly the E2 subunits. Reactivity with the E3…”
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CD46 (MCP) confers protection from lysis by xenogeneic antibodies by Loveland, B E, Johnstone, R W, Russell, S M, Thorley, B R, McKenzie, I F

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Antisense oligonucleotides decrease expression of human CD46, a regulator of complement by Milland, J, Loveland, B E, Russell, S M, McKenzie, I F

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