Search Results - "Lovelace, Jonathan W."

Translation-relevant EEG phenotypes in a mouse model of Fragile X Syndrome by Lovelace, Jonathan W., Ethell, Iryna M., Binder, Devin K., Razak, Khaleel A.

“…Identification of comparable biomarkers in humans and validated animal models will facilitate pre-clinical to clinical therapeutic pipelines to treat…”
Get full text

Acute pharmacological inhibition of matrix metalloproteinase‐9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice by Pirbhoy, Patricia S., Rais, Maham, Lovelace, Jonathan W., Woodard, Walker, Razak, Khaleel A., Binder, Devin K., Ethell, Iryna M.

“…Individuals with Fragile X Syndrome (FXS) and autism spectrum disorder (ASD) exhibit cognitive impairments, social deficits, increased anxiety, and sensory…”
Get full text

Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome by Jonak, Carrie R., Lovelace, Jonathan W., Ethell, Iryna M., Razak, Khaleel A., Binder, Devin K.

“…Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability with symptoms that include increased anxiety and social and sensory…”
Get full text

Matrix metalloproteinase-9 deletion rescues auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome by Lovelace, Jonathan W, Wen, Teresa H, Reinhard, Sarah, Hsu, Mike S, Sidhu, Harpreet, Ethell, Iryna M, Binder, Devin K, Razak, Khaleel A

“…Abstract Sensory processing deficits are common in autism spectrum disorders, but the underlying mechanisms are unclear. Fragile X Syndrome (FXS) is a leading…”
Get full text

Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome by Kulinich, Anna O., Reinhard, Sarah M., Rais, Maham, Lovelace, Jonathan W., Scott, Veronica, Binder, Devin K., Razak, Khaleel A., Ethell, Iryna M.

“…Fragile X syndrome (FXS) is the most common genetic cause of autism and intellectual disability. Fragile X mental retardation gene (Fmr1) knock-out (KO) mice…”
Get full text

Minocycline Treatment Reverses Sound Evoked EEG Abnormalities in a Mouse Model of Fragile X Syndrome by Lovelace, Jonathan W., Ethell, Iryna M., Binder, Devin K., Razak, Khaleel A.

“…Fragile X Syndrome (FXS) is a leading known genetic cause of autism with symptoms that include intellectual disability, anxiety, social impairments and sensory…”
Get full text

Functional consequences of postnatal interventions in a mouse model of Fragile X syndrome by Rais, Maham, Lovelace, Jonathan W., Shuai, Xinghao S., Woodard, Walker, Bishay, Steven, Estrada, Leo, Sharma, Ashwin R., Nguy, Austin, Kulinich, Anna, Pirbhoy, Patricia S., Palacios, Arnold R., Nelson, David L., Razak, Khaleel A., Ethell, Iryna M.

“…Fragile X syndrome (FXS) is a leading genetic cause of autism and intellectual disability with cortical hyperexcitability and sensory hypersensitivity…”
Get full text

Reusable Multielectrode Array Technique for Electroencephalography in Awake Freely Moving Mice by Jonak, Carrie R, Lovelace, Jonathan W, Ethell, Iryna M, Razak, Khaleel A, Binder, Devin K

“…Translational comparison of rodent models of neurological and neuropsychiatric diseases to human electroencephalography (EEG) biomarkers in these conditions…”
Get full text

Increased 2-arachidonoyl-sn-glycerol levels normalize cortical responses to sound and improve behaviors in Fmr1 KO mice by Pirbhoy, Patricia S, Jonak, Carrie R, Syed, Rashid, Argueta, Donovan A, Perez, Pedro A, Wiley, Mark B, Hessamian, Keon, Lovelace, Jonathan W, Razak, Khaleel A, DiPatrizio, Nicholas V, Ethell, Iryna M, Binder, Devin K

“…Background Individuals with Fragile X syndrome (FXS) and autism spectrum disorder (ASD) exhibit an array of symptoms, including sociability deficits, increased…”
Get full text

Vagal sensory neurons mediate the Bezold–Jarisch reflex and induce syncope by Lovelace, Jonathan W., Ma, Jingrui, Yadav, Saurabh, Chhabria, Karishma, Shen, Hanbing, Pang, Zhengyuan, Qi, Tianbo, Sehgal, Ruchi, Zhang, Yunxiao, Bali, Tushar, Vaissiere, Thomas, Tan, Shawn, Liu, Yuejia, Rumbaugh, Gavin, Ye, Li, Kleinfeld, David, Stringer, Carsen, Augustine, Vineet

“…Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders 1 . The Bezold–Jarisch reflex (BJR),…”
Get full text

Developmental Changes in EEG Phenotypes in a Mouse Model of Fragile X Syndrome by Wen, Teresa H., Lovelace, Jonathan W., Ethell, Iryna M., Binder, Devin K., Razak, Khaleel A.

“…•Development of EEG phenotypes in Fmr1 KO mice was examined.•Baseline gamma power was increased in the frontal cortex at all ages tested.•N1 amplitude and…”
Get full text

Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome by Lovelace, Jonathan W, Rais, Maham, Palacios, Arnold R, Shuai, Xinghao S, Bishay, Steven, Popa, Otilia, Pirbhoy, Patricia S, Binder, Devin K, Nelson, David L, Ethell, Iryna M, Razak, Khaleel A

“…Abstract Fragile X syndrome (FXS) is a leading genetic cause of autism with symptoms that include sensory processing deficits. In both humans with FXS and a…”
Get full text

Modulation of posttraumatic epileptogenesis in aquaporin‐4 knockout mice by Szu, Jenny I., Patel, Dillon D., Chaturvedi, Som, Lovelace, Jonathan W., Binder, Devin K.

“…Objective To determine the role of aquaporin‐4 (AQP4) in posttraumatic epileptogenesis using long‐term video‐electroencephalographic (vEEG) recordings. Here,…”
Get full text

Nicotine reduces age-related changes in cortical neural oscillations without affecting auditory brainstem responses by Rumschlag, Jeffrey A., Lovelace, Jonathan W., Kokash, Jamiela, Hussain, Anjum, Razak, Khaleel A.

“…Neural oscillations at specific frequency bands are associated with cognitive functions and can identify abnormalities in cortical dynamics. In this study, we…”
Get full text

Mechanisms underlying auditory processing deficits in Fragile X syndrome by McCullagh, Elizabeth A., Rotschafer, Sarah E., Auerbach, Benjamin D., Klug, Achim, Kaczmarek, Leonard K., Cramer, Karina S., Kulesza, Randy J., Razak, Khaleel A., Lovelace, Jonathan W., Lu, Yong, Koch, Ursula, Wang, Yuan

“…Autism spectrum disorders (ASD) are strongly associated with auditory hypersensitivity or hyperacusis (difficulty tolerating sounds). Fragile X syndrome (FXS),…”
Get full text

An animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity by Lovelace, Jonathan W., Corches, Alex, Vieira, Philip A., Hiroto, Alex S., Mackie, Ken, Korzus, Edward

“…Cannabis continues to be the most accessible and popular illicit recreational drug. Whereas current data link adolescence cannabinoid exposure to increased…”
Get full text

Prefrontal NMDA receptors expressed in excitatory neurons control fear discrimination and fear extinction by Vieira, Philip A., Corches, Alex, Lovelace, Jonathan W., Westbrook, Kevin B., Mendoza, Michael, Korzus, Edward

“…N-methyl-D-aspartate receptors (NMDARs) are critically involved in various learning mechanisms including modulation of fear memory, brain development and brain…”
Get full text

Impaired Fear Memory Specificity Associated with Deficient Endocannabinoid-Dependent Long-Term Plasticity by LOVELACE, Jonathan W, VIEIRA, Philip A, CORCHES, Alex, MACKIE, Ken, KORZUS, Edward

“…In addition to its central role in learning and memory, N-methyl D-aspartate receptor (NMDAR)-dependent signaling regulates central glutamatergic synapse…”
Get full text

Prefrontal Consolidation Supports the Attainment of Fear Memory Accuracy by Vieira, Philip A, Lovelace, Jonathan W, Corches, Alex, Rashid, Asim J, Josselyn, Sheena A, Korzus, Edward

“…The neural mechanisms underlying the attainment of fear memory accuracy for appropriate discriminative responses to aversive and nonaversive stimuli are…”
Get full text

Identification of neuronal connections between heart and brain that trigger fainting

Get full text