Search Results - "Love, James D."

A naturally occurring antiviral ribonucleotide encoded by the human genome by Gizzi, Anthony S., Grove, Tyler L., Arnold, Jamie J., Jose, Joyce, Jangra, Rohit K., Garforth, Scott J., Du, Quan, Cahill, Sean M., Dulyaninova, Natalya G., Love, James D., Chandran, Kartik, Bresnick, Anne R., Cameron, Craig E., Almo, Steven C.

“…Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to viral…”
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Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex by Garrett-Thomson, Sarah C, Massimi, Aldo, Fedorov, Elena V, Bonanno, Jeffrey B, Scandiuzzi, Lisa, Hillerich, Brandan, Seidel, Ronald D, Love, James D, Garforth, Scott J, Guha, Chandan, Almo, Steven C

“…The B7 family represents one of the best-studied subgroups within the Ig superfamily, yet new interactions continue to be discovered. However, this binding…”
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The structural basis of fatty acid elongation by the ELOVL elongases by Nie, Laiyin, Pascoa, Tomas C., Pike, Ashley C. W., Bushell, Simon R., Quigley, Andrew, Ruda, Gian Filippo, Chu, Amy, Cole, Victoria, Speedman, David, Moreira, Tiago, Shrestha, Leela, Mukhopadhyay, Shubhashish M. M., Burgess-Brown, Nicola A., Love, James D., Brennan, Paul E., Carpenter, Elisabeth P.

“…Very long chain fatty acids (VLCFAs) are essential building blocks for the synthesis of ceramides and sphingolipids. The first step in the fatty acid…”
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Panoramic view of a superfamily of phosphatases through substrate profiling by Huang, Hua, Pandya, Chetanya, Liu, Chunliang, Al-Obaidi, Nawar F., Wang, Min, Zheng, Li, Keating, Sarah Toews, Aono, Miyuki, Love, James D., Evans, Brandon, Seidel, Ronald D., Hillerich, Brandan S., Garforth, Scott J., Almo, Steven C., Mariano, Patrick S., Dunaway-Mariano, Debra, Allen, Karen N., Farelli, Jeremiah D.

“…Significance Here, we examine the activity profile of the haloalkanoic acid dehalogenase (HAD) superfamily by screening a customized library against >200…”
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Structural genomics for drug design against the pathogen Coxiella burnetii by Franklin, Matthew C., Cheung, Jonah, Rudolph, Michael J., Burshteyn, Fiana, Cassidy, Michael, Gary, Ebony, Hillerich, Brandan, Yao, Zhong-Ke, Carlier, Paul R., Totrov, Maxim, Love, James D.

“…ABSTRACT Coxiella burnetii is a highly infectious bacterium and potential agent of bioterrorism. However, it has not been studied as extensively as other…”
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Control of carotenoid biosynthesis through a heme-based cis-trans isomerase by Beltrán, Jesús, Kloss, Brian, Hosler, Jonathan P, Geng, Jiafeng, Liu, Aimin, Modi, Anuja, Dawson, John H, Sono, Masanori, Shumskaya, Maria, Ampomah-Dwamena, Charles, Love, James D, Wurtzel, Eleanore T

“…Carotenoid biosynthesis requires isomerization of the central double bond. Informatic, spectroscopic and functional characterization of Z-ISO, a protein…”
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A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease by Schwabe, John W. R, Kallenberger, Bettina C, Love, James D, Chatterjee, V. Krishna K

“…Nuclear receptors are transcription factors that activate gene expression in response to ligands. The C-terminal helix (helix 12) of the ligand-binding domain…”
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Structural Insights into the Interaction and Activation of Histone Deacetylase 3 by Nuclear Receptor Corepressors by Codina, Anna, Love, James D., Li, Yun, Lazar, Mitchell A., Neuhaus, David, John W. R. Schwabe, Chambon, Pierre

“…SMRT (silencing mediator of retinoid acid and thyroid hormone receptor) and NCoR (nuclear receptor corepressor) are transcriptional corepressors that play an…”
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Better and faster: improvements and optimization for mammalian recombinant protein production by Almo, Steven C, Love, James D

“…Thanks to numerous technological advances, the production of recombinant proteins in mammalian cell lines has become an increasingly routine task that is no…”
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Expression of Prokaryotic Integral Membrane Proteins in E. coli by Love, James D

“…Production of prokaryotic membrane proteins for structural and functional studies in E. coli can be parallelized and miniaturized. All stages from cloning,…”
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The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K by Bushell, Simon R., Pike, Ashley C. W., Falzone, Maria E., Rorsman, Nils J. G., Ta, Chau M., Corey, Robin A., Newport, Thomas D., Christianson, John C., Scofano, Lara F., Shintre, Chitra A., Tessitore, Annamaria, Chu, Amy, Wang, Qinrui, Shrestha, Leela, Mukhopadhyay, Shubhashish M. M., Love, James D., Burgess-Brown, Nicola A., Sitsapesan, Rebecca, Stansfeld, Phillip J., Huiskonen, Juha T., Tammaro, Paolo, Accardi, Alessio, Carpenter, Elisabeth P.

“…Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid scramblases and flip/floppases. However, for some intracellular…”
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Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2 by Soniat, Michael, Sampathkumar, Parthasarathy, Collett, Garen, Gizzi, Anthony S., Banu, Radhika N., Bhosle, Rahul C., Chamala, Swetha, Chowdhury, Sukanya, Fiser, Andras, Glenn, Alan S., Hammonds, James, Hillerich, Brandan, Khafizov, Kamil, Love, James D., Matikainen, Bridget, Seidel, Ronald D., Toro, Rafael, Rajesh Kumar, P., Bonanno, Jeffery B., Chook, Yuh Min, Almo, Steven C.

“…Import-Karyopherin or Importin proteins bind nuclear localization signals (NLSs) to mediate the import of proteins into the cell nucleus. Karyopherin β2 or…”
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Experimental Strategies for Functional Annotation and Metabolism Discovery: Targeted Screening of Solute Binding Proteins and Unbiased Panning of Metabolomes by Vetting, Matthew W, Al-Obaidi, Nawar, Zhao, Suwen, San Francisco, Brian, Kim, Jungwook, Wichelecki, Daniel J, Bouvier, Jason T, Solbiati, Jose O, Vu, Hoan, Zhang, Xinshuai, Rodionov, Dmitry A, Love, James D, Hillerich, Brandan S, Seidel, Ronald D, Quinn, Ronald J, Osterman, Andrei L, Cronan, John E, Jacobson, Matthew P, Gerlt, John A, Almo, Steven C

“…The rate at which genome sequencing data is accruing demands enhanced methods for functional annotation and metabolism discovery. Solute binding proteins…”
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The Structural Basis for the Specificity of Retinoid-X Receptor-selective Agonists: New Insights Into the Role of Helix H12 by Love, James D., Gooch, John T., Benko, Szilvia, Li, Chuan, Nagy, Laszlo, Chatterjee, V. Krishna K., Evans, Ronald M., Schwabe, John W.R.

“…Ligands that specifically target retinoid-X receptors (RXRs) are emerging as potentially powerful therapies for cancer, diabetes, and the lowering of…”
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Molecular Determinants of the Balance between Co-repressor and Co-activator Recruitment to the Retinoic Acid Receptor by Benko, Szilvia, Love, James D., Beládi, Marta, Schwabe, John W.R., Nagy, Laszlo

“…The repressive and activating states of nuclear hormone receptors are achieved through the recruitment of cofactor proteins. The binding of co-repressors and…”
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Author Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome by Gizzi, Anthony S., Grove, Tyler L., Arnold, Jamie J., Jose, Joyce, Jangra, Rohit K., Garforth, Scott J., Du, Quan, Cahill, Sean M., Dulyaninova, Natalya G., Love, James D., Chandran, Kartik, Bresnick, Anne R., Cameron, Craig E., Almo, Steven C.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Protein production from the structural genomics perspective: achievements and future needs by Almo, Steven C, Garforth, Scott J, Hillerich, Brandan S, Love, James D, Seidel, Ronald D, Burley, Stephen K

“…•Prokaryotic expression platforms have been implemented in high-throughput structural biology environments.•Significant progress has been made towards…”
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Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome by Gizzi, Anthony S., Grove, Tyler L., Arnold, Jamie J., Jose, Joyce, Jangra, Rohit K., Garforth, Scott J., Du, Quan, Cahill, Sean M., Dulyaninova, Natalya G., Love, James D., Chandran, Kartik, Bresnick, Anne R., Cameron, Craig E., Almo, Steven C.

“…Change history: In the HTML version of this Letter, Extended Data Fig. 4 incorrectly corresponded to Fig. 4 (the PDF version of the figure was correct). This…”
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Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile by Boskovic, Zarko V, Kemp, Melissa M, Freedy, Allyson M, Viswanathan, Vasanthi S, Pop, Marius S, Fuller, Jason H, Martinez, Nicole M, Figueroa Lazú, Samuel O, Hong, Jiyoung A, Lewis, Timothy A, Calarese, Daniel, Love, James D, Vetere, Amedeo, Almo, Steven C, Schreiber, Stuart L, Koehler, Angela N

“…Unbiased binding assays involving small-molecule microarrays were used to identify compounds that display unique patterns of selectivity among members of the…”
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Ultra High‐throughput Screening Uncovers New Activities in Phosphatases of the Haloalkanoic Acid Dehalogenase Superfamily (HADSF) by Farelli, Jeremiah D, Huang, Hua, Liu, Chunliang, Pandya, Chetanya, Al Obaidi, Nawar F, Hillerich, Brandan S., Love, James D, Almo, Steven C, Dunaway‐Mariano, Debra, Allen, Karen N

“…Abstract only Since the first genomes were sequenced, there has been an exponential increase of protein sequences deposited into databases worldwide. This…”
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