Search Results - "Lovato, Debbie M"

Novel ABCG2 Antagonists Reverse Topotecan-Mediated Chemotherapeutic Resistance in Ovarian Carcinoma Xenografts by Ricci, Jerec W, Lovato, Debbie M, Severns, Virginia, Sklar, Larry A, Larson, Richard S

“…Chemotherapeutic resistance remains a challenge in the treatment of ovarian carcinoma, especially in recurrent disease. Despite the fact that most patients…”
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Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors by Hathaway, Helen J, Butler, Kimberly S, Adolphi, Natalie L, Lovato, Debbie M, Belfon, Robert, Fegan, Danielle, Monson, Todd C, Trujillo, Jason E, Tessier, Trace E, Bryant, Howard C, Huber, Dale L, Larson, Richard S, Flynn, Edward R

“…Breast cancer detection using mammography has improved clinical outcomes for many women, because mammography can detect very small (5 mm) tumors early in the…”
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Magnetic relaxometry with an atomic magnetometer and SQUID sensors on targeted cancer cells by Johnson, Cort, Adolphi, Natalie L., Butler, Kimberly L., Lovato, Debbie M., Larson, Richard, Schwindt, Peter D.D., Flynn, Edward R.

“…Magnetic relaxometry methods have been shown to be very sensitive in detecting cancer cells and other targeted diseases. Superconducting quantum interference…”
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A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates by Fowler, Alexandra, Van Rompay, Koen K. A., Sampson, Maureen, Leo, Javier, Watanabe, Jennifer K., Usachenko, Jodie L., Immareddy, Ramya, Lovato, Debbie M., Schiller, John T., Remaley, Alan T., Chackerian, Bryce

“…Elevated low-density lipoprotein cholesterol (LDL-C) is an important risk factor in the development of atherosclerotic cardiovascular disease (ASCVD)…”
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Imaging of Her2-targeted magnetic nanoparticles for breast cancer detection: comparison of SQUID-detected magnetic relaxometry and MRI by Adolphi, Natalie L, Butler, Kimberly S, Lovato, Debbie M, Tessier, T E, Trujillo, Jason E, Hathaway, Helen J, Fegan, Danielle L, Monson, Todd C, Stevens, Tyler E, Huber, Dale L, Ramu, Jaivijay, Milne, Michelle L, Altobelli, Stephen A, Bryant, Howard C, Larson, Richard S, Flynn, Edward R

“…Both magnetic relaxometry and magnetic resonance imaging (MRI) can be used to detect and locate targeted magnetic nanoparticles, noninvasively and without…”
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Individuals with Metabolic Syndrome Show Altered Fecal Lipidomic Profiles with No Signs of Intestinal Inflammation or Increased Intestinal Permeability by Coleman, Mia J, Espino, Luis M, Lebensohn, Hernan, Zimkute, Marija V, Yaghooti, Negar, Ling, Christina L, Gross, Jessica M, Listwan, Natalia, Cano, Sandra, Garcia, Vanessa, Lovato, Debbie M, Tigert, Susan L, Jones, Drew R, Gullapalli, Rama R, Rakov, Neal E, Torrazza Perez, Euriko G, Castillo, Eliseo F

“…Metabolic Syndrome (MetS) is a clinical diagnosis where patients exhibit three out of the five risk factors: hypertriglyceridemia, low high-density lipoprotein…”
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Development of antibody-tagged nanoparticles for detection of transplant rejection using biomagnetic sensors by Butler, Kimberly S, Lovato, Debbie M, Adolphi, Natalie L, Belfon, Robert, Fegan, Danielle L, Monson, Todd C, Hathaway, Helen J, Huber, Dale L, Tessier, T E, Bryant, H C, Flynn, Edward R, Larson, Richard S

“…Organ transplantation is a life-saving procedure and the preferred method of treatment for a growing number of disease states. The advent of new…”
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High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters by Ivnitski-Steele, Irena, Larson, Richard S, Lovato, Debbie M, Khawaja, Hadya M, Winter, Stuart S, Oprea, Tudor I, Sklar, Larry A, Edwards, Bruce S

“…Up-regulation of pump (transporter) expression and selection of resistant cancer cells result in cancer multidrug resistance to diverse substrates of these…”
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Characterization of single-core magnetite nanoparticles for magnetic imaging by SQUID relaxometry by Adolphi, Natalie L, Huber, Dale L, Bryant, Howard C, Monson, Todd C, Fegan, Danielle L, Lim, Jitkang, Trujillo, Jason E, Tessier, Trace E, Lovato, Debbie M, Butler, Kimberly S, Provencio, Paula P, Hathaway, Helen J, Majetich, Sara A, Larson, Richard S, Flynn, Edward R

“…Optimizing the sensitivity of SQUID (superconducting quantum interference device) relaxometry for detecting cell-targeted magnetic nanoparticles for in vivo…”
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Modeling the efficiency of a magnetic needle for collecting magnetic cells by Butler, Kimberly S, Adolphi, Natalie L, Bryant, H C, Lovato, Debbie M, Larson, Richard S, Flynn, Edward R

“…As new magnetic nanoparticle-based technologies are developed and new target cells are identified, there is a critical need to understand the features…”
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Enhanced leukemia cell detection using a novel magnetic needle and nanoparticles by Jaetao, Jason E, Butler, Kimberly S, Adolphi, Natalie L, Lovato, Debbie M, Bryant, Howard C, Rabinowitz, Ian, Winter, Stuart S, Tessier, Trace E, Hathaway, Helen J, Bergemann, Christian, Flynn, Edward R, Larson, Richard S

“…Acute leukemia is a hematopoietic malignancy for which the accurate measurement of minimal residual disease is critical to determining prognosis and treatment…”
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Characterization of magnetite nanoparticles for SQUID-relaxometry and magnetic needle biopsy by Adolphi, Natalie L., Huber, Dale L., Jaetao, Jason E., Bryant, Howard C., Lovato, Debbie M., Fegan, Danielle L., Venturini, Eugene L., Monson, Todd C., Tessier, Trace E., Hathaway, Helen J., Bergemann, Christian, Larson, Richard S., Flynn, Edward R.

“…Magnetite nanoparticles (Chemicell SiMAG-TCL) were characterized by SQUID-relaxometry, susceptometry, and TEM. The magnetization detected by SQUID-relaxometry…”
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Genetic alterations determine chemotherapy resistance in childhood T‐ALL: modelling in stage‐specific cell lines and correlation with diagnostic patient samples by Estes, David A., Lovato, Debbie M., Khawaja, Hadya M., Winter, Stuart S., Larson, Richard S.

“…Summary Acquired drug resistance eventually leads to treatment failure in T‐cell acute lymphoblastic leukaemia (T‐ALL). Immunophenotypic and cytogenetic…”
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High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent by Winter, Stuart S, Lovato, Debbie M, Khawaja, Hadya M, Edwards, Bruce S, Steele, Irena D, Young, Susan M, Oprea, Tudor I, Sklar, Larry A, Larson, Richard S

“…The overexpression of P-glycoprotein, encoded by the ATP Binding Cassette B1 (ABCB1) gene, contributes to multidrug resistance (MDR) and is considered one of…”
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De Novo Expression of ATP Binding Cassette C1 (ABCC1) on T-ALL Cells Confers Resistance to Vincristine Independent of an MDR1 Phenotype by Winter, Stuart S., Khawaja, Hadya M., Lovato, Debbie M., Larson, Richard S.

“…Acquired drug resistance eventually leads to treatment failure in T-cell acute lymphoblastic leukemia (T-ALL). To define mechanisms of vincristine…”
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Identification of Chemotherapy-Resistant Mechanisms in Childhood T-ALL Cell Lines: Correlation with Genetic Profiles in Patients Having Early Treatment Failure by Estes, David A., Lovato, Debbie M., Khawaja, Hadya M., Winter, Stuart S., Larson, Richard S.

“…Acquisition of drug resistance in childhood T-cell acute lymphoblastic leukemia (T-ALL) is a major cause of treatment failure. Drug resistant cell lines are…”
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Noninvasive Approach to Detection of T-Cell Mediated Graft Rejection through Antibody-Tagged Nanoparticles Using SQUID Detection by Jaetao, Jason E., Lovato, Debbie M., Sergatskov, Dmitri A., Bergemann, Christian, Bryant, Howard C., Flynn, Edward R., Larson, Richard S.

“…Organ transplantation is a life-saving procedure for patients. However, acute T-cell mediated graft rejection occurs in a significant quantity of recipients,…”
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Identification of Off-Patent Drugs That Reverse Daunorubicin Efflux Mediated by ABCB1 in T-ALL Cells by Winter, Stuart S., Lovato, Debbie M., Khawaja, Hadya M., Edwards, Bruce S., Steele, Irena D., Young, Susan M., Oprea, Tudor I., Sklar, Larry A., Larson, Richard S.

“…In acute leukemias, the overexpression of P-glycoprotein, encoded by the ATP Binding Cassette B1 (ABCB1) gene contributes to multidrug resistance (MDR), and is…”
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Establishment and Indentification of Genetic Alterations in Chemotherapy-Resistant T-ALL Cell Lines by Estes, David A., Poria, Rahul, Lovato, Debbie M., Khawaja, Hadya M., Quan, Claudia L., Winter, Stuart S., Larson, Richard S.

“…Acquisition of drug resistance in tumor cells in children with T-cell acute lymphoblastic leukemia (T-ALL) during chemotherapy results in relapse and poor…”
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