Search Results - "Louzada‐Júnior, Paulo"

Neutrophil extracellular traps mediate bone erosion in rheumatoid arthritis by enhancing RANKL‐induced osteoclastogenesis by Schneider, Ayda Henriques, Taira, Thaise Mayumi, Públio, Gabriel Azevedo, Silva Prado, Douglas, Donate Yabuta, Paula Barbim, Santos, Jéssica Cristina, Machado, Caio Cavalcante, Souza, Flávio Falcão Lima, Rodrigues Venturini, Lucas Gabriel, Oliveira, Renê Donizeti Ribeiro, Cunha, Thiago Mattar, Alves‐Filho, José Carlos, Louzada‐Júnior, Paulo, Aparecida da Silva, Tarcília, Fukada, Sandra Yasuyo, Cunha, Fernando Queiróz

“…Background and Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause bone erosion due to increased osteoclastogenesis. Neutrophils…”
Get full text

Neutrophil extracellular traps in rheumatoid arthritis and periodontitis: Contribution of PADI4 gene polymorphisms by Oliveira, Sicília Rezende, Arruda, José Alcides Almeida, Schneider, Ayda Henriques, Bemquerer, Larissa Marques, Souza, Rayssa Maria Soalheiro, Barbim, Paula, Mattos‐Pereira, Gustavo Henrique, Calderaro, Débora Cerqueira, Machado, Caio Cavalcante, Alves, Sandra Fukada, Moreira, Paula Rocha, Oliveira, Renê Donizeti Ribeiro, Louzada‐Júnior, Paulo, Abreu, Lucas Guimarães, Cunha, Fernando Queiroz, Silva, Tarcília Aparecida

“…Aim We sought to investigate the release of neutrophil extracellular traps (NETs) in neutrophils from individuals with rheumatoid arthritis (RA) and controls…”
Get full text

Efficacy and safety of Ixekizumab vs. low-dose IL-2 vs. Colchicine vs. standard of care in the treatment of patients hospitalized with moderate-to-critical COVID-19: A pilot randomized clinical trial (STRUCK: Survival Trial Using Cytokine Inhibitors) by Bonifácio, Lívia Pimenta, Ramacciotti, Eduardo, Agati, Leandro Barile, Vilar, Fernando Crivelenti, Silva, Anna Christina Tojal da, Louzada Júnior, Paulo, Fonseca, Benedito Antônio Lopes da, Souza, Hayala Cristina Cavenague de, Oliveira, Caroline Candida Carvalho de, Aguiar, Valéria Cristina Resende, Quadros, Carlos Augusto de Aguiar, Dusilek, Cesar, Itinose, Kengi, Risson, Ricardo, Ferreira, Lucas Roberto Rivabem, Lopes, Renato Delascio, Kallas, Esper Georges, Bellissimo-Rodrigues, Fernando

“…Cases of coronavirus disease 2019 (COVID-19) requiring hospitalization continue to appear in vulnerable populations, highlighting the importance of novel…”
Get full text

Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis by Peres, Raphael S, Santos, Gabriela B, Cecilio, Nerry T, Jabor, Valquíria A P, Niehues, Michael, Torres, Bruna G S, Buqui, Gabriela, Silva, Carlos H T P, Costa, Teresa Dalla, Lopes, Norberto P, Nonato, Maria C, Ramalho, Fernando S, Louzada-Júnior, Paulo, Cunha, Thiago M, Cunha, Fernando Q, Emery, Flavio S, Alves-Filho, Jose C

“…The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven…”
Get full text

Is there an Inflammation Role for MYD88 in Rheumatoid Arthritis? by Gomes da Silva, Isaura Isabelle Fonseca, Lima, Camilla Albertina Dantas, Silva, José Eduardo Adelino, Rushansky, Eliezer, Mariano, Maria Helena Queiroz Araujo, Rolim, Patrícia, Oliveira, Renê Donizeti Ribeiro, Louzada-Júnior, Paulo, Souto, Fabricio Oliveira, Crovella, Sergio, de Azevêdo Silva, Jaqueline, Sandrin-Garcia, Paula

“…Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease with strong genetic influence, especially upon immune response components. Several…”
Get full text

Real-life data of survival and reasons for discontinuation of biological disease-modifying drugs ‘in’ rheumatoid arthritis by Gomides, Ana Paula Monteiro, de Albuquerque, Cleandro Pires, Santos, Ana Beatriz Vargas, Bértolo, Manoel Barros, Júnior, Paulo Louzada, Giorgi, Rina Dalva Neubarth, Radominski, Sebastião Cezar, Resende Guimarães, Maria Fernanda B., Bonfiglioli, Karina Rossi, de Fátima Lobato da Cunha Sauma, Maria, Pereira, Ivânio Alves, Brenol, Claiton Viegas, da Mota, Licia Maria Henrique, Pinheiro, Geraldo da Rocha Castelar

“…Background Rheumatoid arthritis is a chronic, autoimmune disease in which treatment has evolved with a variety of therapeutic classes. Biological…”
Get full text

Methotrexate and Non-Surgical Periodontal Treatment Change the Oral-Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study by Oliveira, Sicília Rezende, de Arruda, José Alcides Almeida, Corrêa, Jôice Dias, Carvalho, Valessa Florindo, Medeiros, Julliane Dutra, Schneider, Ayda Henriques, Machado, Caio Cavalcante, Duffles, Letícia Fernanda, Fernandes, Gabriel da Rocha, Calderaro, Débora Cerqueira, Júnior, Mario Taba, Abreu, Lucas Guimarães, Fukada, Sandra Yasuyo, Oliveira, Renê Donizeti Ribeiro, Louzada-Júnior, Paulo, Cunha, Fernando Queiroz, Silva, Tarcília Aparecida

“…This study evaluated the changes in the composition of oral-gut microbiota in patients with rheumatoid arthritis (RA) caused by methotrexate (MTX) and…”
Get full text

Extra-articular manifestations of rheumatoid arthritis remain a major challenge: data from a large, multi-centric cohort by Bonfiglioli, Karina Rossi, de Medeiros Ribeiro, Ana Cristina, Carnieletto, Ana Paula, Pereira, Ivânio, Domiciano, Diogo Souza, da Silva, Henrique Carriço, Pugliesi, Alisson, Pereira, Leticia Rocha, Guimarães, Maria Fernanda Resende, Giorgi, Rina Dalva Neubarth, Reis, Ana Paula Monteiro Gomides, Brenol, Claiton Viegas, Louzada-Júnior, Paulo, da Cunha Sauma, Maria de Fátima Lobato, Radominski, Sebastião Cezar, da Mota, Licia Maria Henrique, da Rocha Castelar-Pinheiro, Geraldo

“…Although Rheumatoid Arthritis (RA) extra-articular manifestations (ExtRA) occurrence has been decreasing over time, they are still a major mortality risk…”
Get full text

T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis by Cavalcanti, Catarina Addobbati Jordão, Germoglio, Vanessa, de Azevêdo Silva, Jaqueline, Glesse, Nadine, Vianna, Priscila, Cechim, Giovana, Monticielo, Odirlei Andre, Xavier, Ricardo Machado, Brenol, João Carlos Tavares, Brenol, Claiton Viegas, Fragoso, Thiago Sotero, Barbosa, Alexandre Domingues, Duarte, Ângela Luiza Branco Pinto, Oliveira, Renê Donizeti Ribeiro, Louzada-Júnior, Paulo, Donadi, Eduardo Antônio, Chies, José Artur Bogo, Crovella, Sergio, Sandrin-Garcia, Paula

“…The aim of the present study was to evaluate the impact of SEMA4A genetic variants on expression of sema4A protein and its relation to autoimmunity development…”
Get full text

Correlation between Systemic Lupus Erythematosus Activity and Plasma Levels of Monomeric Prolactin and Macroprolactin by Toffoli Ribeiro, Camila, Louzada Júnior, Paulo, de Sá, Marcos Felipe Silva

“…The correlation of prolactin (PRL) levels with SLE activity is a controversial issue, which could be explained by the presence of macroprolactin (MPRL), a high…”
Get more information

Do it fast! Early access to specialized care improved long-term outcomes in rheumatoid arthritis: data from the REAL multicenter observational study by Albuquerque, Cleandro Pires, Reis, Ana Paula Monteiro Gomides, Vargas Santos, Ana Beatriz, Bértolo, Manoel Barros, Júnior, Paulo Louzada, Neubarth Giorgi, Rina Dalva, Radominski, Sebastião Cezar, Guimarães, Maria Fernanda B Resende, Bonfiglioli, Karina Rossi, L Cunha Sauma, Maria de Fátima, Pereira, Ivânio Alves, Brenol, Claiton Viegas, Henrique Mota, Licia Maria, Santos-Neto, Leopoldo, Castelar Pinheiro, Geraldo Rocha

“…Early rheumatoid arthritis (RA) offers an opportunity for better treatment outcomes. In real-life settings, grasping this opportunity might depend on access to…”
Get full text

Decreasing delays in the diagnosis and treatment of rheumatoid arthritis in Brazil: a nationwide multicenter observational study by de Albuquerque, Cleandro Pires, Reis, Ana Paula Monteiro Gomides, Santos, Ana Beatriz Vargas, Bértolo, Manoel Barros, Júnior, Paulo Louzada, Giorgi, Rina Dalva Neubarth, Radominski, Sebastião Cezar, Resende Guimarães, Maria Fernanda B, Bonfiglioli, Karina Rossi, da Cunha Sauma, Maria de Fátima L, Pereira, Ivânio Alves, Brenol, Claiton Viegas, da Mota, Licia Maria Henrique, Santos-Neto, Leopoldo, Castelar Pinheiro, Geraldo R

“…Management delays imply worse outcomes in rheumatoid arthritis (RA) and, therefore, should be minimized. We evaluated changes in diagnostic and treatment…”
Get full text

Cardiovascular risk comorbidities in rheumatoid arthritis patients and the use of anti-rheumatic drugs: a cross-sectional real-life study by Vicente, Gustavo Nogueira Schincariol, Pereira, Ivânio Alves, de Castro, Gláucio Ricardo Werner, da Mota, Licia Maria Henrique, Carnieletto, Ana Paula, de Souza, Dhara Giovanna Santin, da Gama, Fabiana Oenning, Santos, Ana Beatriz Vargas, de Albuquerque, Cleandro Pires, Bértolo, Manoel Barros, Júnior, Paulo Louzada, Giorgi, Rina Dalva Neubarth, Radominski, Sebastião Cezar, Guimarães, Maria Fernanda Brandão Resende, Bonfiglioli, Karina Rossi, Sauma, Maria de Fátima Lobato da Cunha, Brenol, Claiton Viegas, da Rocha Castelar Pinheiro, Geraldo

“…Rheumatoid arthritis (RA) is a common autoimmune systemic inflammatory disease. In addition to joint involvement, RA patients frequently have other…”
Get full text

Rheumatoid artrhitis treatment in Brazil: data from a large real-life multicenter study by Gomides, Ana Paula Monteiro, de Albuquerque, Cleandro Pires, Santos, Ana Beatriz Vargas, Bértolo, Manoel Barros, Júnior, Paulo Louzada, Giorgi, Rina Dalva Neubarth, Radominski, Sebastião Cezar, Resende Guimarães, Maria Fernanda B, Bonfiglioli, Karina Rossi, de Fátima Lobato da Cunha Sauma, Maria, Pereira, Ivânio Alves, Brenol, Claiton Viegas, da Mota, Licia Maria Henrique, da Rocha Castelar Pinheiro, Geraldo

“…Last decades witnessed great technological advances in rheumatoid arthritis (RA) management, but their implementation in clinical practice might prove…”
Get full text

The REAL study: a nationwide prospective study of rheumatoid arthritis in Brazil by da Rocha Castelar-Pinheiro, Geraldo, Vargas-Santos, Ana Beatriz, de Albuquerque, Cleandro Pires, Bértolo, Manoel Barros, Júnior, Paulo Louzada, Giorgi, Rina Dalva Neubarth, Radominski, Sebastião Cezar, Resende Guimarães, Maria Fernanda B, Bonfiglioli, Karina Rossi, Sauma, Maria de Fátima Lobato da Cunha, Pereira, Ivânio Alves, Brenol, Claiton Viegas, Coutinho, Evandro Silva Freire, da Mota, Licia Maria Henrique

“…There are few data on the epidemiology, clinical manifestations and management of RA in Brazil, even with the recognition of the high direct, indirect and…”
Get full text

2017 recommendations of the Brazilian Society of Rheumatology for the pharmacological treatment of rheumatoid arthritis by Mota, Licia Maria Henrique da, Kakehasi, Adriana Maria, Gomides, Ana Paula Monteiro, Duarte, Angela Luzia Branco Pinto, Cruz, Bóris Afonso, Brenol, Claiton Viegas, de Albuquerque, Cleandro Pires, Castelar Pinheiro, Geraldo da Rocha, Laurindo, Ieda Maria Magalhães, Pereira, Ivanio Alves, Bertolo, Manoel Barros, Ubirajara Silva de Souza, Mariana Peixoto Guimarães, de Freitas, Max Vitor Carioca, Louzada-Júnior, Paulo, Xavier, Ricardo Machado, Giorgi, Rina Dalva Neubarth

“…The objective of this document is to provide a comprehensive update of the recommendations of Brazilian Society of Rheumatology on drug treatment of rheumatoid…”
Get full text

Tibolone in postmenopausal women with systemic lupus erythematosus: A pilot study by Vieira, Carolina Sales, Pereira, Fábio Vasconcelos, de Sá, Marcos Felipe Silva, Júnior, Paulo Louzada, Martins, Wellington Paula, Ferriani, Rui Alberto

“…Abstract Objective To determine the influence of the use of tibolone on the frequency of flares of systemic lupus erythematosus (SLE) in postmenopausal…”
Get full text

Increased mitochondrial ROS generation mediates the loss of the anti‐contractile effects of perivascular adipose tissue in high‐fat diet obese mice by Costa, Rafael Menezes, Fais, Rafael S, Dechandt, Carlos R P, Louzada‐Junior, Paulo, Alberici, Luciane C, Lobato, Núbia S, Tostes, Rita C

“…Background and Purpose Obesity is associated with structural and functional changes in perivascular adipose tissue (PVAT), favouring release of reactive oxygen…”
Get full text

Discordance between the patient's and physician's global assessment in rheumatoid arthritis: Data from the REAL study-Brazil by Guimarães, Maria Fernanda Brandão Resende, Pinto, Maria Raquel da Costa, Resende, Gustavo Gomes, Machado, Carla Jorge, Vargas-Santos, Ana Beatriz, Amorim, Rodrigo Balbino Chaves, Gomides, Ana Paula Monteiro, Albuquerque, Cleandro Pires de, Bértolo, Manoel Barros, Júnior, Paulo Louzada, Santos, Isabela Araújo, Giorgi, Rina Dalva Neubarth, Saciloto, Nathalia de Carvalho, Radominski, Sebastião Cezar, Borghi, Fernanda Maria, Bonfiglioli, Karina Rossi, Silva, Henrique Carriço da, Sauma, Maria de Fátima L da Cunha, Sauma, Marcel Lobato, Medeiros, Júlia Brito de, Pereira, Ivânio Alves, Castro, Gláucio Ricardo Werner de, Brenol, Claiton Viegas, Xavier, Ricardo Machado, Mota, Licia Maria Henrique, Castelar-Pinheiro, Geraldo da Rocha

“…Discordance between patient's global assessment (PtGA) and physician's global assessment (PhGA) has been described in rheumatoid arthritis (RA). Understanding…”
Get full text

Musculoskeletal Disease in MDA5‐Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud's Arthropathy by de Carvalho, Luciana Martins, Ngoumou, Gonza, Park, Ji Woo, Ehmke, Nadja, Deigendesch, Nikolaus, Kitabayashi, Naoki, Melki, Isabelle, Souza, Flávio Falcäo L., Tzschach, Andreas, Nogueira‐Barbosa, Marcello H., Ferriani, Virgínia, Louzada‐Junior, Paulo, Marques, Wilson, Lourenço, Charles M., Horn, Denise, Kallinich, Tilmann, Stenzel, Werner, Hur, Sun, Rice, Gillian I., Crow, Yanick J.

“…Objective To define the molecular basis of a multisystem phenotype with progressive musculoskeletal disease of the hands and feet, including camptodactyly,…”
Get full text