Search Results - "Loures, Flavio V."

Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps by Loures, Flávio V, Röhm, Marc, Lee, Chrono K, Santos, Evelyn, Wang, Jennifer P, Specht, Charles A, Calich, Vera L G, Urban, Constantin F, Levitz, Stuart M

“…Plasmacytoid dendritic cells (pDCs) were initially considered as critical for innate immunity to viruses. However, our group has shown that pDCs bind to and…”
Get full text

Dectin-1 Induces M1 Macrophages and Prominent Expansion of CD8⁺IL-17⁺ Cells in Pulmonary Paracoccidioidomycosis by Loures, Flávio V., Araújo, Eliseu F., Feriotti, Claudia, Bazan, Silvia B., Costa, Tânia A., Brown, Gordon D., Calich, Vera L. G.

“…Dectin-1, the innate immune receptor that recognizes β-glucan, plays an important role in immunity against fungal pathogens. Paracoccidioides brasiliensis, the…”
Get full text

Toll-Like Receptor 4 Signaling Leads to Severe Fungal Infection Associated with Enhanced Proinflammatory Immunity and Impaired Expansion of Regulatory T Cells by Loures, Flávio V, Pina, Adriana, Felonato, Maíra, Araújo, Eliseu F, Leite, Katia R.M, Calich, Vera L.G

“…Toll-like receptors (TLRs) present in innate immune cells recognize pathogen molecular patterns and influence immunity to control the host-parasite…”
Get full text

AhR Ligands Modulate the Differentiation of Innate Lymphoid Cells and T Helper Cell Subsets That Control the Severity of a Pulmonary Fungal Infection by de Araújo, Eliseu F, Loures, Flávio V, Preite, Nycolas W, Feriotti, Cláudia, Galdino, Nayane Al, Costa, Tânia A, Calich, Vera L G

“…In agreement with other fungal infections, immunoprotection in pulmonary paracoccidioidomycosis (PCM) is mediated by Th1/Th17 cells whereas disease progression…”
Get full text

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence by Ries, Laure N A, Pardeshi, Lakhansing, Dong, Zhiqiang, Tan, Kaeling, Steenwyk, Jacob L, Colabardini, Ana Cristina, Ferreira Filho, Jaire A, de Castro, Patricia A, Silva, Lilian P, Preite, Nycolas W, Almeida, Fausto, de Assis, Leandro J, Dos Santos, Renato A C, Bowyer, Paul, Bromley, Michael, Owens, Rebecca A, Doyle, Sean, Demasi, Marilene, Hernández, Diego C R, Netto, Luís Eduardo S, Pupo, Monica T, Rokas, Antonis, Loures, Flavio V, Wong, Koon H, Goldman, Gustavo H

“…Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which…”
Get full text

Anti-CD25 treatment depletes Treg cells and decreases disease severity in susceptible and resistant mice infected with Paracoccidioides brasiliensis by Felonato, Maíra, Pina, Adriana, de Araujo, Eliseu Frank, Loures, Flávio V, Bazan, Silvia B, Feriotti, Cláudia, Calich, Vera L G

“…Regulatory T (Treg) cells are fundamental in the control of immunity and excessive tissue pathology. In paracoccidioidomycosis, an endemic mycosis of Latin…”
Get full text

Indoleamine 2,3-dioxygenase controls fungal loads and immunity in Paracoccidioidomicosis but is more important to susceptible than resistant hosts by Araújo, Eliseu F, Loures, Flávio V, Bazan, Silvia B, Feriotti, Claudia, Pina, Adriana, Schanoski, Alessandra S, Costa, Tânia A, Calich, Vera L G

“…Paracoccidioidomycosis, a primary fungal infection restricted to Latin America, is acquired by inhalation of fungal particles. The immunoregulatory mechanisms…”
Get full text

Loss- and Gain-of-Function Approaches Indicate a Dual Role Exerted by Regulatory T Cells in Pulmonary Paracoccidioidomycosis by Bazan, Silvia B, Costa, Tania A, de Araújo, Eliseu Frank, Feriotti, Claudia, Loures, Flávio V, Pretel, Fernando D, Calich, Vera L G

“…Paracoccidioidomycosis (PCM), is a pulmonary fungal disease whose severity depends on the adequate development of T cell immunity. Although regulatory T (Treg)…”
Get full text

In pulmonary paracoccidioidomycosis IL-10 deficiency leads to increased immunity and regressive infection without enhancing tissue pathology by Costa, Tânia A, Bazan, Silvia B, Feriotti, Claudia, Araújo, Eliseu F, Bassi, Ênio J, Loures, Flávio V, Calich, Vera L G

“…Cellular immunity is the main defense mechanism in paracoccidioidomycosis (PCM), the most important systemic mycosis in Latin America. Th1 immunity and IFN-γ…”
Get full text

Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88 by Castoldi, Angela, Andrade-Oliveira, Vinicius, Aguiar, Cristhiane Favero, Amano, Mariane Tami, Lee, Jennifer, Miyagi, Marcelli Terumi, Latância, Marcela Teatin, Braga, Tarcio Teodoro, da Silva, Marina Burgos, Ignácio, Aline, Carola Correia Lima, Joanna Darck, Loures, Flavio V., Albuquerque, José Antonio T., Macêdo, Marina Barguil, Almeida, Rafael Ribeiro, Gaiarsa, Jonas W., Luévano-Martínez, Luis A., Belchior, Thiago, Hiyane, Meire Ioshie, Brown, Gordon D., Mori, Marcelo A., Hoffmann, Christian, Seelaender, Marília, Festuccia, Willian T., Moraes-Vieira, Pedro Manoel, Câmara, Niels Olsen Saraiva

“…The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of…”
Get full text

Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas by Souza De Lima, Dhêmerson, Bomfim, Caio C B, Leal, Vinícius N C, Reis, Edione C, Soares, Jaíne L S, Fernandes, Fernanda P, Amaral, Eduardo P, Loures, Flavio V, Ogusku, Mauricio M, Lima, Maria R D'Imperio, Sadahiro, Aya, Pontillo, Alessandra

“…The interplay between (Mtb) and humans is multifactorial. The susceptibility/resistance profile and the establishment of clinical tuberculosis (TB) still…”
Get full text

Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis by Nogueira-Neto, Joes, Loures, Flavio V., Schanoski, Alessandra S., Andrade, David A. G., Gonzatti, Michelangelo B., Costa, Tania A., Vivanco, Bruno C., Xander, Patrícia, Rosa, Daniela S., Calich, Vera L. G., Keller, Alexandre C.

“…Invariant Natural Killer T (iNKT) cells are key players in the immunity to several pathogens; however, their involvement in the resistance to Paracoccidioides…”
Get full text

Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis by Calich, Vera Lucia Garcia, Serezani, Carlos Henrique, Costa, Tânia A., Feriotti, Cláudia, Araújo, Eliseu F. de, Loures, Flávio V., Ribeiro, Laura R. R., Jancar, Sonia

“…Cysteinyl leukotrienes (CysLTs) and lipoxins (LXs) are lipid mediators that control inflammation, with the former inducing and the latter inhibiting this…”
Get full text

TLR2 Is a Negative Regulator of Th17 Cells and Tissue Pathology in a Pulmonary Model of Fungal Infection by Loures, Flavio V, Pina, Adriana, Felonato, Maira, Calich, Vera L. G

“…To study the role of TLR2 in a experimental model of chronic pulmonary infection, TLR2-deficient and wild-type mice were intratracheally infected with…”
Get full text

A proteomics-MM/PBSA dual approach for the analysis of SARS-CoV-2 main protease substrate peptide specificity by Gallo, Gloria, Barcick, Uilla, Coelho, Camila, Salardani, Murilo, Camacho, Maurício F., Cajado-Carvalho, Daniela, Loures, Flávio V., Serrano, Solange M.T., Hardy, Leon, Zelanis, André, Würtele, Martin

“…The main protease Mpro of SARS-CoV-2 is a well-studied major drug target. Additionally, it has been linked to this virus’ pathogenicity, possibly through…”
Get full text

Depletion of regulatory T cells in ongoing paracoccidioidomycosis rescues protective Th1/Th17 immunity and prevents fatal disease outcome by Galdino, Nayane A. L., Loures, Flávio V., de Araújo, Eliseu F., da Costa, Tania A., Preite, Nycolas W., Calich, Vera Lúcia G.

“…In human paracoccidioidomycosis (PCM), a primary fungal infection typically diagnosed when the disease is already established, regulatory T cells (Treg) cells…”
Get full text

TLR-4 cooperates with Dectin-1 and mannose receptor to expand Th17 and Tc17 cells induced by Paracoccidioides brasiliensis stimulated dendritic cells by Loures, Flávio V, Araújo, Eliseu F, Feriotti, Claudia, Bazan, Silvia B, Calich, Vera L G

“…The concomitant use of diverse pattern recognition receptors (PRRs) by innate immune cells can result in synergistic or inhibitory activities that profoundly…”
Get full text

MyD88 Signaling Is Required for Efficient Innate and Adaptive Immune Responses to Paracoccidioides brasiliensis Infection by Loures, Flávio V, Pina, Adriana, Felonato, Maíra, Feriotti, Claudia, de Araújo, Eliseu F, Calich, Vera L.G

“…The mechanisms that govern the initial interaction between Paracoccidioides brasiliensis, a primary dimorphic fungal pathogen, and cells of the innate immunity…”
Get full text

Mannosyl-recognizing receptors induce an M1-like phenotype in macrophages of susceptible mice but an M2-like phenotype in mice resistant to a fungal infection by Feriotti, Claudia, Loures, Flávio V, Frank de Araújo, Eliseu, da Costa, Tania Alves, Calich, Vera L G

“…In addition to alpha1,3 glucan, mannan and mannan-linked proteins are expressed in the outer layer of Paracoccidioides brasiliensis yeasts. The recognition of…”
Get full text

Regulatory T cells in paracoccidioidomycosis by Calich, Vera L. G., Mamoni, Ronei L., Loures, Flávio V.

“…This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in…”
Get full text